Hepatoprotective effect of Hydro-alcohol extract of Mimusops elengi root against antitubercular drug-induced hepatotoxicity in rats
Prakash Dabadi1, Fouad Saleih Resq AL-Suede2,3*, Chandrashekhar VM4*, Mallappa Shalavadi 4 , Ashok Gnanasekaran5
Journal of Angiotherapy 6(2) 646-653 https://doi.org/10.25163/angiotherapy.625314
Submitted: 03 July 2022 Revised: 08 August 2022 Published: 24 August 2022
Development of therapeutics for the treatment of hepatotoxicity and oxidative stress induced by ATDs
Abstract
Introduction: Nowadays, different chemicals and drugs are causing liver injuries including first-line antitubercular drugs (ATDs). There is a need to find safe and potent moieties of hepatoprotective drugs against liver diseases from different natural resources including medicinal plants. So, the current study aimed to evaluate the hepatoprotective property of Mimusops elengi root. Methodology: Mimusops elengi root extract (200-400mg/kg) was evaluated in an induced hepatotoxicity model of oxidative stress in Wistar rats by ATDs orally for 14 days. Markers indicating oxidative stress and hepatic damage such as serum transaminase (SGOT / SGPT), and alkaline phosphatase (ALP) were measured. Biomarkers of antioxidant status, superoxide dismutase, catalase, glutathione reductase, and marker of lipid peroxidation, were evaluated using standard procedures. The hematological lipid profile, bilirubin, glucose, and histopathological examination were also assessed. Results: intoxication with ATDs markedly reduced the hematological indices and elevated the biochemical enzyme markers (SGOT, SGPT, ALP p<0.001) and lipid profile (p<0.001), decreased and glucose was elevated. However, pretreatment with Mimusops elengi root extract significantly (p<0.001, p<0.01) improved this alteration and sustained the antioxidant potential. The Histopathological and biochemical data support hepatoprotective action. Conclusion: The results of the current study reinforced the extract of Mimusops elengi possesses significant hepatoprotective and antioxidant activity against ATDs- induced hepatotoxicity.
Keywords: Hepatoprotective, Mimusops elengi, Isoniazid, Rifampicin, Anti-TB.
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