A Retrospective Study of Outbreak and Vaccination on Measles Inflammation

Hayder Sudan Abbas Obaid; Ali Jaafar Mohammed; Laith A.I.K. Al-Kaif; *; Doaa Adil Abood; Younis A.K. Al-Khafaji

doi:10.25163/angiotherapy.829533

Angiogenesis, Inflammation & Therapeutics | Online ISSN 2207-872X

RESEARCH ARTICLE (Open Access)

A Retrospective Study of Outbreak and Vaccination on Measles Inflammation

Hayder Sudan Abbas Obaid ¹, Ali Jaafar Mohammed ¹, Laith A.I.K. Al-Kaif ^{2, *}, Doaa Adil Abood ³, Younis A.K. Al-Khafaji ⁴

+ Author Affiliations

Journal of Angiotherapy 8 (2) 1-10 https://doi.org/10.25163/angiotherapy.829533

Submitted: 12 January 2024 Revised: 28 February 2024 Published: 29 February 2024

Abstract

Background: Measles is a highly infectious viral disease as a significant global public health concern, particularly in low-income countries with inadequate healthcare facilities. This study determined the prevalence and risk factors of measles infection, vaccination rates, and surveillance effectiveness in Babylon and Karbala provinces of Iraq from 2020 to 2022. Method: Surveillance data on suspected and confirmed measles cases were collected and analyzed using descriptive statistics and multivariate logistic regression models. Results: Results showed that males, children aged 1-10 years, and residents of rural areas, particularly Ain Al-Tammr/Karbala, were more susceptible to measles. 93 confirmed measles cases were reported, with 13 in Babylon and 80 in Karbala. Non-vaccinated individuals had a significantly higher risk of infection. The study found 11 confirmed cases among vaccinated and unknown individuals, while 71 cases were among non-vaccinated individuals. Vaccine efficacy varied, indicating challenges in achieving effective community immunity. Poor vaccination coverage was attributed to administrative issues, inadequate resources, and vaccine hesitancy. Males were disproportionately affected compared to females. Conclusion: The study demonstrated the importance of strengthening vaccination programs, improving surveillance systems, and enhancing public awareness to combat measles outbreaks and reduce morbidity and mortality, especially among vulnerable populations. Improvements in vaccine coverage, proper vaccine handling, and prompt reporting of suspected cases are all necessary to eliminate measles from Iraq, with a special focus on the provinces of Babylon and Karbala.

Keywords: Measles, Vaccination, Public health, Iraq, Surveillance

References

Abd RM, hassan KS, Noaman AA. (2021) Evaluation of Measles Vaccination Program in Diyala Governorate. Review of International Geographical Education (RIGEO). 11(12): 649-656.

Ait-Oufella H, Horvat B, Kerdiles Y, Herbin O, Gourdy P, Khallou-Laschet J, et al (2007). Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice. Circulation. ; 116(15); 1707-1713.

Akkaif M, Daud N, Noor D, Sha'aban A, Sk Abdul Kader M, Wahab M, et al. (2023) The use of ticagrelor versus clopidogrel in Malaysian patients with coronary artery disease undergoing percutaneous coronary intervention (PCI): Does the age tertile affect the platelet reactivity? European Heart Journal. ; 44(Supplement_1): ehac779. 122.

Akkaif M, Sha'aban A, Daud N, Noor D, Musa N, Sk Abdul Kader M, et al. (2022) Fast and more affordable CYP2C19 LOF testing to personalized of clopidogrel therapy. European Heart Journal, 43(Supplement_2), ehac544. 3025.

Akkaif MA and Daud NAA. (2022) Ethical considerations of the genetic testing for patients with cardiovascular disease. Malaysian Journal of Human Genetics ; 3(1): 13-17.

Akkaif MA, Bitar AN, Al-Kaif LAIK, Daud NAA, Sha’aban A, Noor DAM, et al. (2022) The Management of Myocardial Injury Related to SARS-CoV-2 Pneumonia. J Cardiovasc Dev Dis. 9(9):307.

Akkaif MA, Daud NA, Noor DA, Sha'aban A, Wahab MJ, Sk Abdul Kader MA, et al.(2023) Platelet reactivity index after treatment of clopidogrel versus ticagrelor based on CYP2C19 genotypes among patients undergoing percutaneous coronary intervention: results of a randomized study. European Heart Journal. 44 (Supplement_1): ehac779-120.

Akkaif MA, Daud NAA, Sha'aban A, Ng ML, Abdul Kader MAS, Noor DAM, et al. (2021) The Role of Genetic Polymorphism and Other Factors on Clopidogrel Resistance (CR) in an Asian Population with Coronary Heart Disease (CHD). Molecules. 26(7):1987.

Akkaif MA, Ng ML, Sk Abdul Kader MA, Daud NAA, Sha'aban A, Ibrahim B. (2021) A review of the effects of ticagrelor on adenosine concentration and its clinical significance. Pharmacol Rep. 73(6):1551-1564.

Akkaif MA, Sha’aban A, Cesaro A, Jaber AAS, Vergara A, Yunusa I, et al.(2022) The impact of SARS-CoV-2 treatment on the cardiovascular system: An updated review. Inflammopharmacology. 30(4): 1143-1151.

Akkaif MA, Sha’aban A, Daud NAA, Yunusa I, Ng ML, SK Abdul Kader MA, et al.(2021) Coronary Heart Disease (CHD) in Elderly Patients: Which Drug to Choose, Ticagrelor and Clopidogrel? A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Cardiovascular Development and Disease. 8(10): 123.

Akkaif MA, Sha'aban A, Daud NAA, Ng ML and Ibrahim B. (2020) Investigate the Strategy of Using Pharmacogenetics and Pharmacometabonomics to the Personalization of Ticagrelor Antiplatelet Therapy. Systematic Reviews in Pharmacy, 11(9), 1100-1107.

Al-Arabi Al-Ghamdi AM, Al-Faraj MH, Ibrahim HM, Al Mamun M. (2011) Epidemiological analysis of notified measles cases and review of surveillance system during an outbreak in Tabuk, Saudi Arabia. Ann Epidemiol. 21(4): 262-271.

Al-Ghamdi, A. M. A. A., Al-Faraj, M. H., Ibrahim, H. M., & Al Mamun, M. (2011). Epidemiological analysis of notified measles cases and review of surveillance system during an outbreak in Tabuk, Saudi Arabia. Annals of Epidemiology, 21(4), 262-271.

Al-Kaif LA, Al-Khafaji YA, Shandaway SK, AL-Janabi UH, Kadhim KJ and Akkaif, MA.(2023) Interleukin-8 and-17 levels in the sera of vaccinated subjects receiving a booster dose of measles virus: A follow-up study in Iraq. Medical Journal of Babylon, 20(2): 422-425.

Atabani S, Landucci G, Steward MW, Whittle H, Tilles JG and Forthal DN.(2000) Sex- associated differences in the antibody-dependent cellular cytotoxicity antibody response to measles vaccines. Clin Diagn Lab Immunol. 7: 111-3.

Bode SM, Gowda C, Mangini M, Kemper AR. COVID-19 and primary measles vaccination rates in a large primary care network. Pediatrics. 2021; 147(1): e2020035576.

Carroll KC, Stephen AM, Timothy M and Steve M. (2016) Medical Microbiology. 26th edition. U.S.A. The McGraw-Hill Companies. Section IV: Virology, Chapter 40.

Feutz K and Shirey D. (2022) Measles: Moving toward eradication. The Nurse practitioner. 47(5): 14–20.

Fine PE and Zell ER. (1994) Outbreaks in highly vaccinated populations: implications for studies of vaccine performance. American journal of epidemiology. 139(1): 77–90.

Gramigna J. (2019) European countries lose measles-free status; US on the brink. Infect. Dis. Child. 32: 7.

Griffin DE, Lin WH and Pan CH. (2012) Measles Virus, Immune Control, and Persistence. FEMS Microbiology Reviews. 36(3): 649-662.

Jasem J, Marof K, Nawar A and Islam M. (2012) Epidemiological analysis of measles and evaluation of measles surveillance system performance in Iraq, 2005–2010. IJID.16: e166–e171.

Jasem, J., Marof, K., Nawar, A., & Islam, K. M. (2012). Epidemiological analysis of measles and evaluation of measles surveillance system performance in Iraq, 2005–2010. International Journal of Infectious Diseases, 16(3), e166-e171.

Jawad AW, Al Hares S, Al Suraifi M, Aldujaili A, Muttaasher H. (2021) Epidemiological characteristics of Under Five Measles cases, Al Najaf Al Ashraf Province, Iraq, 2006-2018 . Kufa Journal for Nursing Sciences, 11(1), 75–82.

Kadim MA, Abdulhasan AF, Abdulrasol ZA, Obaid AF. (2022) Dropout of Vaccination Among Iraqi Children. SAJSSH. 3(6): 163-171.

Kutty P, Rota J, Bellini W, Redd SB, Barskey A and Wallace G. (2013) Measles. VPD Surveillance Manual, 6th Edition. Chapter 7. 1-21.

Leung AK, Hon KL, Leong KF, Sergi CM. (2018)Measles: a disease often forgotten but not gone. Hong Kong Med J. ;24(5):512-520.

Lyimo J. (2012) Uptake of Measles Vaccination Services and Associated Factors Among Under Fives in Temeke District, DAR ES Salaam Region, Tanzania. M.Sc. Thesis, Muhimbili University of Health and Allied Sciences. .

Masrizal RR and Ilham R. (2018) The Occurrence of Measles Disease Among Children Based on Geographic Information System in Pesisir Selatan District. Improving Quality of Life Through Multi Sector Collaboration. 45.

Mina MJ, Kula T, Leng Y, Li M, De Vries RD, Knip M, et al. (2019) Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science, 366(6465): 599–606.

Mohammed AK, Nasir AR, Alsweedy MMJ. (2022). Clinical and epidemiological study of measles cases in central teaching hospital of pediatrics in Babylon Province. Medical Journal of Babylon,19, 518-21.

Nelson AN, Lin WW, Shivakoti R, Putnam NE, Mangus L, Adams RJ, et al. (2020) Association of persistent wild-type measles virus RNA with long-term humoral immunity in rhesus macaques. JCI insight. ; 5(3): e134992.

Nelson KE and Williams CF. (2007) Infectious disease epidemiology: Theory and practice. Jones and Bartlett, Sudbury.

Patel MK, Goodson JL, Alexander Jr JP, Kretsinger K, Sodha SV, Steulet C, et al. (2020) Progress toward regional measles elimination—worldwide, 2000–2019. Morbidity and mortality weekly report. 69(45): 1700.

Pesonen E, Andsberg E, Ohlin H, et al. (2007) Dual role of infections as risk factors for coronary heart disease. Atherosclerosis. ;192(2):370-375.

Rewar S. (2015) Measles Virus: A Perpetual Challenge. Indian Journal of Research in Pharmacy and Biotechnology. ; 3(3):196.

Rota JS, Turner JC, Yost-Daljev MK, Freeman M, Toney DM, Meisel E, et al. Investigation of a mumps outbreak among university students with two measles-mumps-rubella (MMR) vaccinations, Virginia, September-December 2006. Journal of medical virology. 2009; 81(10), 1819–1825.

Shane, A., Hiebert, J., Sherrard, L., & Deehan, H. (2014). Measles in Canada: Measles surveillance in Canada: Trends for 2013. Canada Communicable Disease Report, 40(12), 219

Taniguchi H, Rahman MM, Swe KT, Hussain A, Shibuya K, Hashizume M. Trends and projections of universal health coverage indicators in Iraq, 2000-2030: A national and subnational study. Soc Sci Med. 2021;270:113630.

World Health Organization. (2010). Fourth biregional meeting on the control of japanese encephalitis (JE): 7-8 June 2009, Bangkok, Thailand (No. SEA-Immun-59). WHO Regional Office for South-East Asia.

Zhong Z, Hou J, Li B, Zhang Q, Liu S, Li C, et al.(2017) Analysis of CYP2C19 Genetic Polymorphism in a Large Ethnic Hakka Population in Southern China. Med Sci Monit. 23:6186-6192.

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