Combined Analysis of Tumor RNAseq, Urine Proteomics and WES Profiles from Patient with Gallbladder Cancer
Anton Yuryev A, John Catanzaro B, Md Shamsuddin Sultan Khan C
Journal of Precision Biosciences 1(1) 026-105 https://doi.org/10.25163/biosciences.112091DB112921119
Submitted: 11 October 2019 Revised: 29 October 2019 Published: 02 November 2019
NGS RNAseq tumor transcriptomics profile was generated by Genoanalytica, Moscow Russia. RPKM values for every gene measured in tumor sample were normalized on transcriptomics profile from three samples of normal gallbladder from publicly available GSE132223 data from National Cancer Institute (NCBI): M3-741_tpm, M3-760_tpm, M3-817_tpm
Abstract
Normalized NGS RNAseq tumor transcriptomics profile was imported into Pathway Studio software from Elsevier to determine expression regulators upstream of the differentially expressed genes using sub-network enrichment analysis option “What proteins regulate expression of entities enriched in the input data?”.
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