Nanoparticle-Enhanced Drug Delivery Systems for Targeted Cancer Therapy
Muhit Rana 1*, Kashfia Haque 2, Dong-Jin Lim 3
Biosensors and Nanotheranostics 2(1) 1-13 https://doi.org/10.25163/biosensors.217332
Submitted: 05 February 2023 Revised: 12 April 2023 Published: 17 April 2023
Abstract
Nanoparticle-enhanced drug delivery systems have emerged as a promising strategy to revolutionize cancer therapy by improving drug efficacy, minimizing side effects, and enabling targeted delivery. This review article provides a comprehensive overview of the current landscape of nanoparticle-based drug delivery systems for cancer therapy, focusing on recent advancements, challenges, and future perspectives. Subsequent sections cover the types of nanoparticles, their properties influencing drug delivery, principles of targeted drug delivery, advantages over conventional methods, and recent advances in nanoparticle-based drug delivery systems. Key topics addressed include the design and synthesis of nanoparticle formulations, targeting strategies in cancer therapy, in vitro and in vivo evaluation techniques, clinical translation of nanoparticle therapies, recent advancements such as smart nanoparticles and theranostic platforms, and future trends such as personalized medicine and immunotherapy. Overall, nanoparticle-based drug delivery systems offer a promising approach to overcome challenges associated with conventional cancer treatments, paving the way for personalized and targeted therapies that hold great promise in the fight against cancer.
Keywords: Cancer, Targeted drug delivery, Nanoparticles, Chemotherapy, Multidrug resistance
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