Insights of Curcumin in Prostate Cancer with update: Review

Natasha Binti Ali Imran Dhillon ^1*

Curcumin has significant efficacy for the treatment of prostate cancer in men. The importance of curcuCurcumin has significant efficacy for the treatment of prostate cancer in men. The importance of curcumin in diet and its safety and bioavailability is described in this review.min in diet and its safety and bioavailability is described in this review.

Abstract

Prostate cancer is the most common type of uncontrolled slow-growing cancer in men at 99% cases. The risk of developing prostate cancer is 74 percent higher in African Americans than in non-Hispanic Caucasian men. Prostate cancer patients with the age of 66 to 80 years old show cancerous symptoms who usually die. The natural agent curcumin and its derivatives are widely used for the treatment of prostate cancer. Although the bioavailability of Curcumin is very poor, it shows high efficacy in prostate cancer patients. The clinical trials demonstrate a well-tolerated safety at a high dose 12g/day after oral administration in the patients with malignant or pre-malignant lesions. These studies show minor adverse events such as nausea and diarrhea without other complications. The androgen receptor (AR) gene binding to the prostate-specific antigen (PSA) gene is highly expressed in prostate cancer patients which is found downregulated after the treatment of curcumin. In this review, we have discussed the broad impact and indication of curcumin for the treatment of prostate cancer.

Key Words: prostate cancer, curcumin, clinical trial, androgen receptor

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