Advances in Efficacy of Cuscuta Reflexa Leaf in Diabetes Treatment

Md Shamsuddin Sultan Khan ¹, Mohammed Rahmatullah ^2*

This study explores Cuscuta reflexa's potential as a natural remedy for diabetes, highlighting its therapeutic promise through its bioactive compounds and multiple health benefits.

Abstract

Background: Cuscuta reflexa, commonly known as dodder, is a parasitic plant widely recognized in traditional medicine for its diverse medicinal properties. This article aims to comprehensively review the medicinal potential of Cuscuta reflexa, particularly in the treatment of diabetes and other health conditions. Methods: A thorough literature review was conducted to gather and analyze existing research on Cuscuta reflexa's anti-diabetic properties and its broader pharmacological effects. Studies were reviewed to assess its bioactive components and their pharmacological actions, including antioxidant, anti-inflammatory, and immunomodulatory properties. Preclinical and clinical investigations were also examined to evaluate the safety profile of Cuscuta reflexa-based therapies. Results: Numerous studies have highlighted Cuscuta reflexa's efficacy in managing diabetes by regulating blood glucose levels, improving insulin sensitivity, and alleviating diabetic complications such as retinopathy and nephropathy. Its bioactive components, including phenolic compounds, alkaloids, and flavonoids, exhibit a wide range of pharmacological actions. These include anticancer, neuroprotective, and cardiovascular effects, demonstrating Cuscuta reflexa's potential in targeting various molecular pathways involved in disease development. Preclinical and clinical studies have shown that Cuscuta reflexa-based therapies are well-tolerated with minimal side effects. Conclusion: Cuscuta reflexa emerges as a promising natural remedy with multifaceted therapeutic benefits, particularly for diabetes and other conditions. Despite significant advancements in understanding its pharmacological mechanisms and therapeutic effects, further research is needed to fully elucidate its therapeutic potential, optimize dosage regimens, and explore potential synergistic interactions with conventional therapies.

Keywords: Cuscuta reflexa, dodder, diabetes, therapeutic potential, traditional medicine, bioactive constituents

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