Point-of-care (POC) Assay to Detect Dengue Exposure

Avni A. Argun¹, Muhit Rana^1*

Abstract

Dengue virus (DENV) infection is a life-threatening disease. About 40% of the world population lives in high-risk dengue-endemic areas, and the global incidence has significantly increased in the last three decades. Early DENV detection is critical but also challenging since the primary infection is asymptomatic. The dengue vaccine exists but is less effective and potentially dangerous if the person has no previous exposure to DENV. However, the current immunoassay-based technologies used to distinguish primary and secondary infections are not qualified for point-of-care (POC) because they are neither rapid nor cost-effective. This work aims to develop a dengue-specific POC assay that can detect circulating biomarkers to confirm dengue exposure as early as possible to facilitate a high-throughput vaccination program.

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