Biopharmaceuticals and medical sciences | Online ISSN 3064-9226
REVIEWS   (Open Access)

Individualized Therapeutic Design in Thyroid Disease: Strategies Through Genetic, Molecular, and Technological Innovations

Wei Zhang 1, John A Catanzaro 1*, Shamsuddin Sultan Khan 1*

+ Author Affiliations

Journal of Precision Biosciences 4 (1) 1-11 https://doi.org/10.25163/biosciences.414603

Submitted: 27 February 2022 Revised: 09 April 2022  Published: 10 April 2022 


Abstract

Individualized therapeutic approaches in thyroid disease are revolutionizing clinical care by focusing on treatments tailored to the unique genetic, molecular, and clinical profiles of each patient. With breakthroughs in genetic and molecular profiling, diagnosing and managing thyroid disorders has become more precise and personalized. In conditions like hypothyroidism and thyroid cancer, identifying genetic variations and molecular markers not only helps predict disease progression but also informs targeted treatment strategies, improving outcomes. Personalized therapies have shown to be more effective and less harmful than traditional treatments, particularly in thyroid cancer. However, challenges such as high costs, limited accessibility, and ethical concerns about genetic data use remain, hindering broader adoption. The future of thyroid disease management lies in overcoming these barriers through innovations in bioinformatics, artificial intelligence (AI), and continuous genetic research. By addressing these challenges and safeguarding patient privacy, we can ensure that the benefits of personalized medicine are accessible to all, ultimately transforming the global landscape of thyroid disease care. Conclusion: As personalized medicine continues to advance, the integration of individualized therapeutic strategies into thyroid disease management holds immense promise. By overcoming current challenges and ensuring equitable access to these innovative approaches, the future of thyroid care will be more effective, less invasive, and tailored to the unique needs of each patient. The continued development of genetic, molecular, and technological tools will not only enhance treatment outcomes but also pave the way for a more personalized, patient-centered approach to healthcare.

Keywords: Individualized therapy, thyroid disease, genetic profiling, molecular markers, personalized medicine.

References


Araque, K. A., Gubbi, S., & Klubo-Gwiezdzinska, J. (2020). Updates on the management of thyroid cancer. Hormone and Metabolic Research, 52(08), 562-577.https://doi.org/10.1055/a-1089-7870

Babu, B. K. (2024). Personalized Medicine and Advancements in Pharmacology: Shaping the Future of Healthcare. International Journal of Pharmaceutical Investigation, 14(2). https://doi.org/10.5530/ijpi.14.2.41

Bianchi, S., Santoro, F., & Torreggiani, M. (2023). The role of liver function in drug metabolism. Journal of Clinical Pharmacology, 58(3), 217-225. https://doi.org/10.1002/jcph.2053

Biondi, B., & Cooper, D. S. (2021). The clinical significance of thyroid hormone replacement therapy. Journal of Clinical Endocrinology & Metabolism, 106(9), 2660-2670. https://doi.org/10.1210/clinem/dgab277

Brown, T., Martinez, A., & Silva, R. (2020). Personalized surgical approaches in robotic surgery. Surgical Advances, 11(2), 90-96. https://doi.org/10.1016/j.surg.2020.03.002

Chung, S. E., et al. (2022). Pharmacogenomics and warfarin dosing: A review of current practices. Journal of Cardiovascular Pharmacology, 61(5), 453-462. https://doi.org/10.1097/FJC.0000000000000933

Cooper, D. S. (2005). Hypothyroidism. The Lancet, 365(9452), 623-632. https://doi.org/10.1016/S0140-6736(05)66682- 2

Dong, Y. H., & Fu, D. G. (2014). Autoimmune thyroid disease: mechanism, genetics and current knowledge. Eur Rev Med Pharmacol Sci, 18(23), 3611-3618.

Evans, T., et al. (2022). Nutrition-based interventions in chronic disease management. Clinical Nutrition, 41(7), 1365-1372. https://doi.org/10.1016/j.clnu.2022.03.003

Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., & Mechanick, J. I. (2012). Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. Endocrine Practice, 18(6), 988-1028. https://doi.org/10.4158/EP12180.GL

Harper, A. R., & Topol, E. J. (2012). Pharmacogenomics in clinical practice and drug development. Nature biotechnology, 30(11), 1117-1124.https://doi.org/10.1038/nbt.2424

Harrison, G., et al. (2022). Preoperative optimization in high-risk surgical patients. Journal of Surgery, 33(2), 115-122. https://doi.org/10.1016/j.jsurg.2022.01.007

Haugen, B. R., Alexander, E. K., Bible, K. C., Doherty, G. M., Mandel, S. J., Nikiforov, Y. E., ... & Tuttle, R. M. (2016). 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid, 26(1), 1-133. https://doi.org/10.1089/thy.2015.0020

Hennessey, J. V., Arem, R., & Fraker, D. (2019). The management of hyperthyroidism. Current Opinion in Endocrinology, Diabetes and Obesity, 26(5), 294-300. https://doi.org/10.1097/MED.0000000000000512

Ieni, A., Vita, R., Pizzimenti, C., Benvenga, S., & Tuccari, G. (2021). Intratumoral heterogeneity in differentiated thyroid tumors: An intriguing reappraisal in the era of personalized medicine. Journal of Personalized Medicine, 11(5), 333.https://doi.org/10.3390/jpm1105033

Lattanzi, W., Ripoli, C., Greco, V., Barba, M., Iavarone, F., Minucci, A., ... & Parolini, O. (2021). Basic and preclinical research for personalized medicine. Journal of Personalized Medicine, 11(5), 354.https://doi.org/10.3390/jpm11050354

Lazarus, J. H., Smyth, P. P., & Simmonds, M. J. (2012). Genetic factors influencing thyroid function. Clinical Endocrinology, 77(2), 223-228. https://doi.org/10.1111/j.1365-2265.2012.04469.x

Lupi, C., Raffaelli, M., & Materazzi, G. (2015). Molecular markers and thyroid cancer: Current knowledge and future perspectives. Nature Reviews Endocrinology, 11(4), 199-213. https://doi.org/10.1038/nrendo.2014.197

Marcello, M. A., Malandrino, P., Almeida, J. F. M., Martins, M. B., Cunha, L. L., Bufalo, N. E., ... & Ward, L. S. (2014). The influence of the environment on the development of thyroid tumors: a new appraisal. Endocrine-related cancer, 21(5), T235-T254.https://doi.org/10.1530/ERC-14-0131

Nakao, M., Shirotsuki, K., & Sugaya, N. (2021). Cognitive-behavioral therapy for management of mental health and stress-related disorders: Recent advances in techniques and technologies. BioPsychoSocial medicine, 15(1), 16.https://doi.org/10.1186/s13030-019-0157-

Nguyen, T., et al. (2021). Personalized diets for inflammatory diseases. Inflammatory Health Journal, 14(6), 135-142. https://doi.org/10.1016/j.ihj.2021.02.007

Nikiforov, Y. E. (2011). Thyroid carcinoma: Molecular pathways and therapeutic targets. Modern Pathology, 24(4), 540-548. https://doi.org/10.1038/modpathol.2010.235

Nwoye, E., Woo, W. L., Gao, B., & Anyanwu, T. (2022). Artificial intelligence for emerging technology in surgery: Systematic review and validation. IEEE Reviews in Biomedical Engineering, 16, 241-259.https://doi.org/10.1109/RBME.2022.3183852

Nylén, C., Mechera, R., Maréchal-Ross, I., Tsang, V., Chou, A., Gill, A. J., ... & Glover, A. R. (2020). Molecular markers guiding thyroid cancer management. Cancers, 12(8), 2164.https://doi.org/10.3390/cancers12082164

Radkowski, P., Kedziora, B., Eliszewska, L., Jackowska, K., Mandziuk-Radkowska, O., & Dawidowska-Fidrych, J. (2023). Perioperative management of patients with diabetes. Medical Studies/Studia Medyczne, 39(3), 272-280.https://doi.org/10.5114/ms.2023.131683

Sikaris, K. A. (2020). A practical guide to hypothyroidism management. Internal Medicine Journal, 50(12), 1444-1451. https://doi.org/10.1111/imj.14856

Stewart, L. A., & Kuo, J. H. (2021). Advancements in the treatment of differentiated thyroid cancer. Therapeutic Advances in Endocrinology and Metabolism, 12, 20420188211000251.https://doi.org/10.1177/20420188211000251

Sun, W., & Li, X. (2020). Genetic markers in thyroid disorders and the promise of personalized medicine. Clinical Endocrinology, 92(1), 2-10. https://doi.org/10.1111/cen.14145

Tufano, R. P., Burch, H. B., & Sippel, R. S. (2022). Advances in personalized medicine in thyroid disorders. Endocrinology and Metabolism Clinics of North America, 51(2), 177-193. https://doi.org/10.1016/j.ecl.2022.01.004

Viola, D., Valerio, L., Molinaro, E., Agate, L., Bottici, V., Biagini, A., ... & Elisei, R. (2016). Treatment of advanced thyroid cancer with targeted therapies: ten years of experience. Endocrine-related cancer, 23(4), R185-R205.https://doi.org/10.1530/ERC-15-0555

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