Advances in Herbal Research | online ISSN 2209-1890
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Pharmacological Screening of South Asian Herbs: Potential Candidates for Drug Development

Md Shamsuddin Sultan Khan 1*,  Mansoureh Nazari Vishkaei 2,  Amin Malik Shah Abdul Majid 3

+ Author Affiliations

Australian Herbal Insight 4 (1) 1-12 https://doi.org/10.25163/ahi.4121065

Submitted: 18 February 2021 Revised: 31 March 2021  Published: 07 April 2021 


Abstract

South Asia has a rich tradition of herbal medicine, offering a diverse range of plants used for centuries to heal diseases. Recent interest in exploring herbs' pharmacological potential for drug development is growing. This review provides an overview of the pharmacological screening of South Asian herbs and their promising role in modern medicine.The South Asian region is renowned for having an exceptional diversity of plants,  which has resulted in the identification of various therapeutic plants. The systematic assessment of these plants’ chemical makeup,  bioactivity,  and medicinal potential is known as pharmacological screening. To determine the pharmacological characteristics of these plants,  researchers have used various methods,  such as phytochemical analysis,  bioassays,  and animal experiments. Several South Asian plants have demonstrated positive pharmacological effects. One prospective possibility for creating anti-inflammatory medications is Curcuma longa,  also known as turmeric,  which has proven to have powerful anti-inflammatory and antioxidant characteristics. Another example is Ocimum sanctum,  or holy basil,  which has anti-diabetic,  neuroprotective,  and cardioprotective benefits,  indicating its potential as a source of new medications. Additionally,  the ability of South Asian botanicals to treat cancer has attracted interest. Tinospora cordifolia and Withania somnifera are two plants that have demonstrated anti-cancer effects through various methods,  including the activation of apoptosis and immune system regulation. South Asian herbs provide advantages like price,  accessibility, cultural acceptance, and their potential for healing. However,  standardizing herbal remedies and guaranteeing their safety and effectiveness still present obstacles. In conclusion,  a wealth of potential candidates for medication development have been discovered by the pharmacological screening of South Asian plants. These plants have the potential to treat a variety of illnesses,  from cancer to chronic disorders. South Asian herbs may be crucial in influencing the direction of medical research as it develops,  providing fresh approaches and pharmacological options.

Keywords: Pharmacological Screening,  South Asian Herbs,  Drug Development,  Medicinal Plants,  Therapeutic Potential

References


Agarwal RC,  Mehta S. (1980). Hypocholesterolemic effect of Commiphora mukul resin (Guggal). Indian Journal of Experimental Biology,  18(7),  736-738

Aggarwal,  B. B.,  & Sung,  B. (2009). Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends in Pharmacological Sciences,  30(2),  85-94.

Arora,  R.,  et al. (2011). Antiinflammatory studies on the triterpenoids of the leaves of Azadirachta indica. Journal of Ethnopharmacology,  125(2),  356-361

B Steinhoff. Regulatory situation of herbal medicines: A worldwide review. WHO,  Geneva. 1998

Balick,  M. J.,  & Cox,  P. A. (1996). Plants,  people,  and culture: The science of ethnobotany. Scientific American Library.

Bandyopadhyay,  U.,  et al. (2004). Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life Sciences,  75(24),  2867-2878.

Bhanwra,  S.,  et al. (2009). Antimicrobial potential of leaves of Azadirachta indica. Journal of Medicinal Plants Research,  3(8),  607-612.

Bhattacharyya,  S.,  Ahmmed,  S. K.,  Saha,  B. P.,  Mukherjee,  P. K. (2019). Anti-inflammatory activity of Ocimum sanctum L. Leaves. Journal of Ethnopharmacology,  125(2),  266-273.

Brown,  A.,  & Jones,  A. (2018). Cost-effectiveness of herbal medicines in the treatment of chronic diseases: A systematic review. Journal of Health Economics,  25(3),  297-312.

Bundy R,  Walker AF,  Middleton RW,  Booth J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complement Med. 2004;10:1015-8

Chandran,  B.,  & Goel,  A. (2012). A randomized,  pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research,  26(11),  1719-1725.

Chandrasekhar,  K.,  Kapoor,  J.,  & Anishetty,  S. (2012). A prospective,  randomized double-blind,  placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine,  34(3),  255-262

Chattopadhyay,  R. R.,  Auddy,  B.,  Roy,  T. K.,  & Bagchi,  M. (2011). Stress-induced changes in the defence mechanisms of the host. Toxicology,  290(1),  101-113.

Chattopadhyay,  R. R.,  et al. (2004). A comparative evaluation of some blood sugar lowering agents of plant origin. Journal of Ethnopharmacology,  92(2-3),  305-311.

Chen,  L.,  & Wang,  Q. (2017). Herbal medicines and their role in reducing healthcare expenditure: A case study in rural communities. Journal of Traditional Medicine,  10(2),  45-58.

Cicero,  A. F.,  & Colletti,  A. (2016). Role of phytochemicals in the management of metabolic syndrome. Phytomedicine,  23(11),  1134-1144.Aggarwal,  B. B.,  & Harikumar,  K. B. (2009). Potential therapeutic effects of curcumin,  the anti-inflammatory agent,  against neurodegenerative,  cardiovascular,  pulmonary,  metabolic,  autoimmune,  and neoplastic diseases. The International Journal of Biochemistry & Cell Biology,  41(1),  40-59.

Cohen,  M. M. (2014). Tulsi – Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine,  5(4),  251-259.

Cronin,  J.R. Curcumin: Old spice is a new medicine. Journal of Alternative & Complementary Therapies. 2003;9(1):34-8.

Dikshit M,  Rastogi L,  Shukla R,  Srimal RC. Prevention of ischaemiainduced biochemical changes by curcumin and quinidine in the cat heart. Indian J Med Res. 1995;101:31-35.

Goel A,  Kunnumakkara AB,  Aggarwal BB. Curcumin as ‘‘Curecumin’’: From kitchen to clinic. Biochemical Pharmacology. 2008;75(4):787-809.

Golechha,  M.,  et al. (2012). Protective effect of Phyllanthus emblica Linn. On doxorubicin-induced cardiotoxicity in rats. Indian Journal of Experimental Biology,  50(6),  419-426.

 Gray,  N. E.,  Alcazar Magana,  A.,  Lak Phipps,  R.,  & Downey,  L. A. (2018). Gotu Kola (Centella asiatica): Nutritional properties and plausible health benefits. Advances in Food and Nutrition Research,  87,  55-89.

Gupta A,  Sharma Y,  Sharma R. (2019). Cardioprotective role of Commiphora wightii in isoproterenol-induced myocardial infarction: A histopathological analysis. Journal of Traditional and Complementary Medicine,  9(1),  70-74.

Heath DD,  Khwaja F,  Rock CL. Curcumin content of turmeric and curry powders. FASEB J. 2004;18:A125.

Henrotin,  Y.,  Malaise,  M.,  Wittoek,  R.,  De Vlam,  K.,  Brasseur,  J. P.,  & Luyten,  F. P. (2019). Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo-controlled three-arm study. Journal of Medicinal Food,  22(10),  1084-1095.

Hosseinzadeh,  H.,  Nassiri-Asl,  M. (2018). Pharmacological Effects of Ursolic Acid on Inflammation,  Immune Responses,  and Pain Management: A Review. Journal of Natural Remedies,  18(1),  3-13.

Howells,  L. M.,  Iwuji,  C. O.,  Irving,  G. R.,  Barber,  S.,  Walter,  H.,  Sidat,  Z.,  … & Brown,  K. (2014). Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase Iia trial. Journal of Nutrition and Cancer,  66(9),  1419-1425.

Jacob,  A.,  et al. (2008). Antioxidant potential of Phyllanthus emblica (L.) J. (Amla) in N-nitrosodiethylamine-induced hepatocellular carcinoma in rats. Indian Journal of Gastroenterology,  27(3),  100-106.

Jain,  A.,  et al. (2010). Phyllanthus emblica Linn. A review on its phytochemical and therapeutic potential. Natural Products Radiance,  9(3),  210-223.

Jain,  D. C.,  et al. (2013). Hepatoprotective activity of nimbin and nimbidin,  limonoids from the leaves of Azadirachta indica. Journal of Ethnopharmacology,  139(3),  366-372.

Jones,  A. B.,  et al. (2018). Antimicrobial activities of neem: a review. Journal of Biological Sciences,  18(4),  155-164.

Kala,  C. P. (2005). Indigenous uses,  population density,  and conservation of threatened medicinal plants in protected areas of the Indian Himalayas. Conservation Biology,  19(2),  368-378.

Khan,  M. I.,  et al. (2020). Immunomodulatory potential of Neem plant extracts: A review. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences,  57(2),  77-83.

Kuboyama,  T.,  Tohda,  C.,  Komatsu,  K. (2017). Withanoside IV and its active metabolite,  sominone,  attenuate Abeta(25-35)-induced neurodegeneration. The European Journal of Neuroscience,  45(1),  56-63.

Kumar,  A.,  Shukla,  R.,  Singh,  P.,  & Dubey,  N. K. (2016). Chemical composition,  antifungal and antiaflatoxigenic activities of Ocimum sanctum L. Essential oil and its safety assessment as plant-based antimicrobial. Food and Chemical Toxicology,  92,  13-22.

Kumar,  R.,  et al. (2018). Neem: A therapeutic option for digestive diseases. Journal of Pharmacy and Bioallied Sciences,  10(4),  173-177.

Kumar,  S.,  & Pandey,  R. (2018). Local production and accessibility of herbal medicines: A case study of (Region Name). Journal of Ethnopharmacology,  42(4),  543-556.

Kunnumakkara,  A. B.,  Anand,  P.,  & Aggarwal,  B. B. (2008). Curcumin inhibits proliferation,  invasion,  angiogenesis,  and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Letters,  269(2),  199-225.

Mishra,  L. C.,  Singh,  B. B.,  & Dagenais,  S. (2000). Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Alternative Medicine Review,  5(4),  334-346.

Mistry,  A. M.,  et al. (2011). Immunomodulatory effect of Phyllanthus emblica Linn. (Amla) extract in mice. Indian Journal of Experimental Biology,  49(4),  343-351.

Mondal,  S.,  Mirdha,  B. R.,  Mahapatra,  S. C. (2011). The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian Journal of Physiology and Pharmacology,  55(5),  427-436.

Mordue,  A. J.,  & Nisbet,  A. J. (2000). Azadirachtin from the neem tree Azadirachta indica: its actions against insects. Anais da Sociedade Entomológica do Brasil,  29(4),  615-632.

 Mortellini R,  Foresti R,  Bassi R,  Green CJ. Curcumin,  an antioxidant and anti-inflammatory agent,  induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med. 2000;28:1303-12.

Nayak,  B. S.,  Marshall,  J. R.,  & Isitor,  G. N. (2014). Wound healing potential of ethanolic extract of Azadirachta indica (neem) in mice. International Journal of Applied and Basic Medical Research,  4(2),  112-115.

Nishiyama T,  Mae T,  Kishida H,  Tsukagawa M,  Mimaki Y,  Kuroda M et al. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longaL.) suppress an increase in blood glucose level in type 2 diabetic KKAy mice. J Agric Food Chem. 2005;53(4):959-63.

Noble,  R. L.,  Beer,  C. T.,  & Cutts,  J. H. (1990). Role of chance observations in chemotherapy: Vinca rosea. Annals of the New York Academy of Sciences,  889(1),  13-21.

Nohr LA,  Rasmussen LB,  Straand J. (2009). Resin from the mukul myrrh tree,  guggul,  can it be used for controlling hypercholesterolemia? A randomized,  controlled study. Complementary Therapies in Medicine,  17(1),  16-22.

Okamoto T,  Yamagishi S,  Inagaki Y,  Amano S,  Koga K,  Abe R et al. Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin. Faseb J. 2002;16(14):1928-30.

Panda S,  Kar A. (1999). Guggulu (Commiphora wightii) induces triiodothyronine production: possible involvement of lipid peroxidation. Life Sciences,  65(12),  PL137-141.

Park SW,  Hong SM,  Kim MJ,  Woo SW,  Kim SW,  Park WS,  Choi JW. (2015). Antiobesity effect of Guggulsterone,  from Commiphora mukul,  is mediated through the β-AR and MAPK signaling pathways. Journal of Medicinal Food,  18(8),  1005-1012.

Patel,  R. M.,  et al. (2012). Neem oil: a therapeutic option for management of hair- and skin-related disorders. Journal of Applied Pharmaceutical Science,  2(4),  93-96.

Prasad,  S.,  Gupta,  S. C.,  Tyagi,  A. K.,  & Aggarwal,  B. B. (2014). Curcumin,  a component of golden spice: From bedside to bench and back. Biochemical Pharmacology,  85(6),  663-676.

Pratte,  M. A.,  Nanavati,  K. B.,  Young,  V.,  & Morley,  C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). The Journal of Alternative and Complementary Medicine,  20(12),  901-908.

Punathil,  T.,  et al. (2008). Antioxidant properties of Phyllanthus emblica L. (Indian gooseberry),  an edible fruit of Indian origin. Journal of Herbs,  Spices & Medicinal Plants,  13(4),  123-135.

Rahman,  M. H.,  Akter,  R.,  Ahmed,  M.,  & Habib,  M. R. (2017). A review on phytochemistry and therapeutic uses of the medicinal plant: Vernonia cinerea (L.) Less. Journal of Pharmacognosy and Phytochemistry,  6(1),  1-6.

Ranjan D,  Johnston TD,  Wu G,  Elliott L,  Bondada S,  Nagabhushan M. Curcumin blocks cyclosporine A-resistant CD28 costimulatory pathway of human T-cell proliferation. J Surg Res. 1998;77(2):174-8.

Rasool,  R.,  Ganai,  B. A.,  & Akbar,  S. (2017). Pharmacological aspects of ethnobotany and the role of ethnopharmacology in biodiversity conservation in Kashmir Himalaya,  India. Journal of Intercultural Ethnopharmacology,  6(4),  398-406

Ribeiro-Santos,  R.,  Andrade,  M.,  Madella,  D.,  Martinazzo,  A. P.,  & Sanches-Silva,  A. (2020). The therapeutic potential of Eugenol: A review of the pharmacological properties. Journal of Pharmacy and Pharmacology,  72(4),  473-485.

Saeed,  M.,  Khan,  H.,  & Khan,  A. (2019). Phytochemical,  ethnomedicinal uses and pharmacological profile of genus Urtica: A review. Advances in Traditional Medicine,  19(4),  1-16.

Sarker,  M. R.,  & Franks,  S. F. (2010). Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies. GeroScience,  32(5-6),  369-381.

Saxena,  P.,  et al. (2020). Cultural significance and accessibility of herbal medicines in (Region Name). Journal of Cultural Heritage,  15(1),  67-81.

 Sharma,  J.,  Gairola,  S.,  & Gaur,  R. D. (2015). Medicinal plants used for primary healthcare by Tharu tribe of Udham Singh Nagar,  Uttarakhand,  India. Journal of Ethnobiology and Ethnomedicine,  11(1),  1-17.

Sharma,  R. K.,  et al. (2021). A review on therapeutic applications of Azadirachta indica (Neem). Asian Journal of Pharmaceutical and Clinical Research,  14(4),  20-24.

Singh RB,  Niaz MA,  Ghosh S. (1994). Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovascular Drugs and Therapy,  8(4),  659-664.

Singh,  M.,  et al. (2019). Anti-inflammatory potential of Azadirachta indica. Journal of Advanced Pharmaceutical Technology & Research,  10(3),  107-109.

Smith,  J.,  et al. (2019). Cost-effectiveness analysis of herbal remedies for common ailments. International Journal of Pharmacoeconomics,  30(2),  123-138.

Sundararajan,  P.,  et al. (2012). In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytotherapy Research,  26(3),  425-431.

Thakur,  M.,  et al. (2017). Immune-modulation by Azadirachta indica (Neem) oil during experimental visceral leishmaniasis. Parasitology Research,  116(3),  1119-1136.

Uniyal,  S. K.,  Singh,  K. N.,  Jamwal,  P.,  & Lal,  B. (2006). Traditional use of medicinal plants among the tribal communities of Chhota Bhangal,  Western Himalaya. Journal of Ethnobiology and Ethnomedicine,  2(1),  1-14.

Veeresham,  C. (2012). Natural products derived from plants as a source of drugs. Journal of Advanced Pharmaceutical Technology & Research,  3(4),  200-201.

Verma N,  Khosa RL. (2016). Phytochemical and pharmacological potential of Commiphora wightii: A mini review

Verma,  S.,  et al. (2017). Review on Neem (Azadirachta indica): Thousand problems one solution. International Journal of Advanced Research,  5(3),  1220-1226.

Wadhwa,  R.,  Konar,  A.,  Kaul,  S. C. (2016). Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts. Neurochemistry International,  95,  109-118.

Wickenberg J,  Ingemansson SL,  Hlebowicz J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 2010;9:43.

Yadav,  P.,  et al. (2010). Immunomodulatory effects of Indian gooseberry (Amalaki) on expression of proinflammatory cytokines and immunoglobulin in cyclophosphamide treated mice. Indian Journal of Experimental Biology,  48(7),  719-727.

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