Insights of Curcumin in Prostate Cancer with update: Review
Natasha Binti Ali Imran Dhillon 1*
Australian Herbal Insight 3(1) 011-011 https://doi.org/10.25163/ahi.31210520814160920
Submitted: 14 June 2020 Revised: 12 August 2020 Published: 16 August 2020
Abstract
Prostate cancer is the most common type of uncontrolled slow-growing cancer in men at 99% cases. The risk of developing prostate cancer is 74 percent higher in African Americans than in non-Hispanic Caucasian men. Prostate cancer patients with the age of 66 to 80 years old show cancerous symptoms who usually die. The natural agent curcumin and its derivatives are widely used for the treatment of prostate cancer. Although the bioavailability of Curcumin is very poor, it shows high efficacy in prostate cancer patients. The clinical trials demonstrate a well-tolerated safety at a high dose 12g/day after oral administration in the patients with malignant or pre-malignant lesions. These studies show minor adverse events such as nausea and diarrhea without other complications. The androgen receptor (AR) gene binding to the prostate-specific antigen (PSA) gene is highly expressed in prostate cancer patients which is found downregulated after the treatment of curcumin. In this review, we have discussed the broad impact and indication of curcumin for the treatment of prostate cancer.
Key Words: prostate cancer, curcumin, clinical trial, androgen receptor
References
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 68(6), 394-424. doi:10.3322/caac.21492
Bhowmik, D., Chiranjib., Kumar, K. P. S., Chandira, M., & Jayakar, B. (2009). Turmeric: A herbal and traditional medicine. Archives of Applied Science Research, 1(2), 86-108. Retrieved from https://www.scholarsresearchlibrary.com/articles/turmeric-a-herbal-and-traditional-medicine.pdf
Canadian Cancer Society. (2020). Symptoms of prostate cancer. Retrieved from https://www.cancer.ca/en/cancer-information/cancer-type/prostate/signs-and-symptoms/?region=qc
Centers for Disease Control and Prevention. (2019). What is prostate cancer? Retrieved from https://www.cdc.gov/cancer/prostate/basic_info/what-is-prostate-cancer.htm
Davis, J. N., Kucuk, O., & Sarkar, F. H. (2002). Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells. Molecular Carcinogenesis, 34(2), 91-101. doi:10.1002/mc.10053
Devassy, J. G., Nwachukwu, I. D., & Jones, P. J. (2015). Curcumin and cancer: Barriers to obtaining a health claim. Nutrition Reviews, 73(3), 155–65. doi:10.1093/nutrit/nuu064
Di Pierro, F., Rapacioli, G., Di Maio, E. A., Appendino, G., Franceschi, F., & Togni, S. (2013). Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva ®), nimesulide, and acetaminophen. Journal of Pain Research, 6, 201-205. doi:10.2147/JPR.S42184
Espiritu, S. M. G., Liu, L. Y., Rubanova, Y., Bhandari, V., Holgersen, E. M., Szyca, L. M., ... Boutros, P. C. (2018). The evolutionary landscape of localized prostate cancers drives clinical aggression. Cell, 173(4), 1003-1013.e15. doi.org/10.1016/j.cell.2018.03.029
He, Z. Y., Shi, C. B., Wen, H., Li, F. L., Wang, B. L., & Wang, J. (2011). Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Investigation, 29(3), 208-213. doi:10.3109/07357907.2010.550592
Hoffman, R. M., Gilliland, F. D., Eley, J. W., Harlan, L. C., Stephenson, R. A., Stanford, J. L., ... Potosky, A. L. (2001). Racial and ethnic differences in advanced-stage prostate cancer: The prostate cancer outcomes study. Journal of the National Cancer Institute, 93(5), 388-395. doi.org/10.1093/jnci/93.5.388
Holy, J. (2004). Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells. Cell Motility and Cytoskeleton, 58(4), 253-268. doi:10.1002/cm.20012
Khan, N., Adhami, V. M., & Mukhtar, H. (2010). Apoptosis by dietary agents for prevention and treatment of prostate cancer. Endocrine-related cancer, 17(1), R39–R52. doi.org/10.1677/ERC-09-026
Kunati, S. R., Yang, S., William, B. M., & Xu, Y. (2018). An LC-MS/MS method for simultaneous determination of curcumin, curcumin glucuronide and curcumin sulfate in a phase II clinical trial. Journal of Pharmaceutical and Biomedical Analysis. 156, 189-198. doi: 10.1016/j.jpba.2018.04.034
Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., ... Brenner, D. E. (2006). Dose escalation of a curcuminoid formulation. BMC Complementary Alternative Medicine, 17(6), 10. Doi:10.1186/1472-6882-6-10
Li, J., & Wang, Z. (2016). The pathology of unusual subtypes of prostate cancer. Chinese Journal of Cancer Research, 28(1), 130-143. doi: 10.3978/j.issn.1000-9604.2016.01.06
Liu, C., Yang, X., Wu, W., Long, Z., Xiao, H., Luo, F., ... Lin, Q. (2018). Elaboration of curcumin-loaded rice bran albumin nanoparticles formulation with increased in vitro bioactivity and in vivo bioavailability. Food Hydrocolloids, 77, 834–842. doi: 10.1016/j.foodhyd.2017.11.027
Mishra, S., & Palanivelu, K. (2008). The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Annals of Indian Academy of Neurology, 11(1), 13–19. //doi.org/10.4103/0972-2327.40220
Ma, Y. F., Wu, Z. H., Gao, M., & Loor, J. J. (2018). Nuclear factor erythroid 2-related factor 2 antioxidant response element pathways protect bovine mammary epithelial cells against h 2 o 2-induced oxidative damage in vitro. Journal of Dairy Science, 101(6), 5329-5344. doi: 10.3168/jds.2017-14128
Nakamura, K., Yasunaga, Y., Segawa, T., Ko, D., Moul, J. W., Srivastava, S., ... Rhim, J, S. (2002). Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. International Journal of Oncology, 21(4), 825-830. doi.org/10.3892/ijo.21.4.825
Nee Chakraborty, S. M., Ghosh, U., Bhattacharyy, N. P., Bhattacharyy, R. K., Dey, S., & Roy, M. (2007). Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Molecular Cell Biochemistry, 297, 31. doi.org/10.1007/s11010-006-9319-z
Ohtsu, H., Xiao, Z, Ishida, J., Nagai, M., Wang, H. K., Itokawa, H., ... Lee, K. H. (2002). Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. Journal of Medicinal Chemistry, 45(23), 5037–5042. doi: 10.1021/jm020200g
Oliver, J. M., Stoner, L., Rowlands, D. S., Caldwell, A. R., Sanders, E., Kreutzer, A., ... Jager, R. (2016). Novel form of curcumin improves endothelial function in young, healthy individuals: A double-blind placebo-controlled study. Journal of nutrition and metabolism, 2016, 1089653. https://doi.org/10.1155/2016/1089653
Patel, B. B., & Majumdar, A. P. (2009). Synergistic role of curcumin with current therapeutics in colorectal cancer: Minireview. Nutrition and cancer, 61(6), 842–846. doi.org/10.1080/01635580903285106
Patel, V. B., Misra, S., Patel, B. B., & Majumdar, A. P. (2010). Colorectal cancer: Chemo preventive role of curcumin and resveratrol. Nutrition and cancer, 62(7), 958–967. doi.org/10.1080/01635581.2010.510259
Rawla P. (2019). Epidemiology of Prostate Cancer. World Journal of Oncology, 10(2), 63-89. doi.org/10.14740/wjon1191
Sahebkar, A., Saboni, N., Pirro, M., & Banach, M. (2017). Curcumin: An effective adjunct in patients with statin-associated muscle symptoms? Journal of cachexia, sarcopenia and muscle, 8(1), 19–24. doi.org/10.1002/jcsm.12140
Schmidt, K. T., & Figg, W. D. (2016). The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies. Translational Cancer Research, 5(Suppl 6), S1107–S1110. https://doi.org/10.21037/tcr.2016.11.04
Shenoy, D., Packianathan, S., Chen, A. M., & Vijayakumar, S. (2016). Do African-American men need separate prostate cancer screening guidelines? BMC Journal, 16, 19. doi: 10.1186/s12894-016-0137-7
Stangelberger, A., Waldert M., & Djavan, B. (2008). Prostate cancer in elderly men. Reviews in Urology, 10(2), 111-119. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483315/pdf/RIU010002_0111.pdf
Tamburrino, L., Salvianti, F., Marchiani, S., Pinzani P., Nesi, G., Serni, S., ... Baldi, E. (2012). Androgen receptor (AR) expression in prostate cancer and progression of the tumor: Lessons from cell lines, animal models and human specimens. Steroids. 77(10), 996-1001. doi: 10.1016/j.steroids.2012.01.008
Teiten, M. H., Gaascht, F., Eifes, S., Dicato, M., & Diederich, M. (2010). Chemopreventive potential of curcumin in prostate cancer. Genes and nutrition, 5(1), 61–74. doi.org/10.1007/s12263-009-0152-3
Thakkar, A., Sutaria, D., Grandhi, B. K., Wang, J., & Prabhu, S. (2013). The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncology Reports, 29(4), 1671-1677. doi:10.3892/or.2013.2276
Tomeh, M, A., Hadianamrei, R., & Zhao, X. (2019). A review of curcumin and its derivatives as anticancer agents. International Journal of Molecular Science, 20(5), 1033. doi: 10.3390/ijms20051033
Wagenlehner, F. M. E., Pilatz, A., Weidner, W., & Naber K. G. Prostatitis, epididymitis and orchitis. Infectious Diseases (Fourth Edition). (pp.532). Retrieved from https://www.sciencedirect.com/sdfe/pdf/download/eid/3-s2.0-B9780702062858000587/first-page-pdf
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