Advances in Herbal Research | online ISSN 2209-1890
RESEARCH ARTICLE   (Open Access)

A Review on Cassia alata Pharmacological, Traditional and Medicinal Aspects

Ranjanie Dewia, Yuhanis Firzaa, Mohammed Ali Nashiryb, Fouad Saleih R. Al-Suedeaa*, Aman Shah AbdulMajidc

+ Author Affiliations

Australian Herbal Insight 1(1) 016-021 https://doi.org/10.25163/ahi.110005

Submitted: 02 November 2018  Revised: 24 December 2018  Published: 26 January 2019 

Abstract

Herbalism has a long custom of utilization outside of conventional medication. It is winding up more standard as enhancements in examination and quality control alongside propels in clinical research demonstrate the estimation of natural medication in the treating and averting illness. World Health Organization has detailed that over 60% of individuals are relying upon traditional medication. Plants had been utilized for therapeutic purposes well before any history were even created. Herbal medicines are one sort of dietary supplement. They are sold as tablets, capsules, powders, teas, extracts, and new or dried plants. This article focuses to enhance and prepare a comprehensive review on pharmacological, medicinal and traditional value of Cassia alata plant. Cassia species are outstanding plant broadly dispersed in India and other tropical nations. Diverse parts of the plant (leaves, seed, and root) are presumed for their medicinal values. Several chemical compounds such as anthraquinone glycosides, naphthopyrone glycosides, phenolic compounds, flavonoids etc. have been isolated from this plant and well recognized traditional medicine as laxative and is effective for treatment of leprosy, ringworm infection, ophthalmic, skin diseases and liver disorders. The pharmacological, medicinal and traditional value reported in present review to confirm the therapeutic value of Cassia species to different developing countries. Therefore, this review may provide the compiled information which will guide to develop the novel agent for various disorders from Cassia species. Based on several scientific studies and review articles on Cassia alata species, this plant may suggest a gigantic biological potential.

Key wordsCassia alata, pharmacology, traditional medicine

References

Abo K, Fred-Jaiyesimi A, Jaiyesimi A. Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria. Journal of ethnopharmacology. 2008;115(1):67-71.
https://doi.org/10.1016/j.jep.2007.09.005
PMid:17950547

Adebesin O, Okpuzor J, Iroanya O, Adenekan S, Aniekwena C. Antioxidant and cytotoxic properties of Senna alata and Senna podocarpa leaf extracts. Planta Medica. 2013;79(13):PA27.
https://doi.org/10.1055/s-0033-1351931

Adedayo O, Anderson W, Moo-Young M, Snieckus V, Patil P, Kolawole D. Phytochemistry and antibacterial activity of Senna alata flower. Pharmaceutical biology. 2001;39(6):408-12.
https://doi.org/10.1076/phbi.39.6.408.5880

Adelowo F, Oladeji O. An overview of the phytochemical analysis of bioactive compounds in Senna alata. Am J Chem Biochem Eng. 2017;2:7-14.

Amao S, Ajani R, Oladapo O. Cassia alata alters liver structure in rat. African Journal of Biomedical Research. 2010;13(3):231-3.

Amao S, Ajani R, Oladapo O. Cassia alata alters liver structure in rat. African Journal of Biomedical Research. 2010;13(3):231-3.

Belkin M, Fitzgerald DB. Tumor-damaging capacity of plant materials. I. Plants used as cathartics. Journal of the National Cancer Institute. 1952;13(1):139-55.
PMid:14946504

Chatterjeesup S, Chatterjeesup S, Dutta S. A survey on VAM association in three different species of Cassia and determination of antimicrobial property of these phytoextracts. Journal of Medicinal Plants Research. 2010;4(4):286-92.

Chichioco-Hern CL, Leonido FMG. Weight-lowering effects of Caesalpinia pulcherrima, Cassia fistula and Senna alata leaf extracts. Journal of Medicinal Plants Research. 2011;5(3):452-5.

Duraipandiyan V, Ayyanar M, Ignacimuthu S. Antimicrobial activity of some ethnomedicinal plants used by Paliyar tribe from Tamil Nadu, India. BMC complementary and alternative medicine. 2006;6(1):35.
https://doi.org/10.1186/1472-6882-6-35
PMid:17042964 PMCid:PMC1621080

Girón LM, Freire V, Alonzo A, Cáceres A. Ethnobotanical survey of the medicinal flora used by the Caribs of Guatemala. Journal of Ethnopharmacology. 1991;34(2-3):173-87.
https://doi.org/10.1016/0378-8741(91)90035-C

Girón LM, Freire V, Alonzo A, Cáceres A. Ethnobotanical survey of the medicinal flora used by the Caribs of Guatemala. Journal of Ethnopharmacology. 1991;34(2-3):173-87.
https://doi.org/10.1016/0378-8741(91)90035-C

Hennebelle T, Weniger B, Joseph H, Sahpaz S, Bailleul F. Senna alata. Fitoterapia. 2009;80(7):385-93. https://pfaf.org/user/Plant.aspx?LatinName=Senna+alata/14/10/2018.
https://doi.org/10.1016/j.fitote.2009.05.008
PMid:19446609

Ibrahim D, Osman H. Antimicrobial activity of Cassia alata from Malaysia. Journal of ethnopharmacology. 1995;45(3):151-6.
https://doi.org/10.1016/0378-8741(94)01200-J

Igbe I, Edosuyi O. Toxicity profile of aqueous extract of Cassia alata flower in Wistar rats. Journal of Pharmacy & Bioresources. 2016;13(2):92-102.
https://doi.org/10.4314/jpb.v13i2.5

Ishak R, Abu IF, Lajis HM, Ambia KM, Noah RM. Effects of cassia alata treatment towards cardiovascular oxidative stress in hyperglycemic rats. International Journal of Pharmaceutical Sciences Review and Research. 2015;34(2):254-8.

Kazeem MI, Azeez GA, Ashafa AO. Effect of senna alata (L) roxb (fabaceae) leaf extracts on alpha-amylase, alpha-glucosidase and postprandial hyperglycemia in rats. Tropical Journal of Pharmaceutical Research. 2015;14(10):1843-8.
https://doi.org/10.4314/tjpr.v14i10.15

Khan MH, Yadava P. Antidiabetic plants used in Thoubal district of Manipur, Northeast India. 2010.

Levy A, Lewis A. Cassia alata leaf extract induces cytotoxicity in A549 lung cancer cells via a mechanism that is caspase 8 dependent. West Indian Medical Journal. 2011;60(6):608-14.
PMid:22512216

Lewis AT, Levy AS-A. Anti-inflammatory activities of Cassia alata extract in Complete Freund's Adjuvant arthritis in rats. Federation of American Societies for Experimental Biology; 2012.

Makinde A, Igoli J, Ta'Ama L, Shaibu S, Garba A. Antimicrobial activity of Cassia alata. African journal of biotechnology. 2007;6(13).

Mannan A, Kawser MJ, Ahmed AA, Islam NN, Alam SM, Khan MAE, et al. Assessment of antibacterial, thrombolytic and cytotoxic potential of Cassia alata seed oil. Journal of Applied Pharmaceutical Science. 2011;1(9):56.

Mohammed AR. Phytochemical, cytotoxicity and antioxidant investigation of Cassia alata leaves growing in Egypt. Journal of Innovations in Pharmaceutical and Biological Sciences. 2017; l (4), 97-105

Moriyama H, Iizuka T, Nagai M, Miyataka H, Satoh T. Antiinflammatory activity of heat-treated Cassia alata leaf extract and its flavonoid glycoside. Yakugaku Zasshi. 2003;123(7):607-11.
https://doi.org/10.1248/yakushi.123.607
PMid:12875244

Nadimpalli S. Should the use of complementary and alternative medicine be restricted? International Journal of Basic & Clinical Pharmacology. 2017;5(5):1691-4.

Naowaboot J, Piyabhan P. Senna alata leaf extract restores insulin sensitivity in high-fat diet-induced obese mice. Clinical Phytoscience. 2017;2(1):18.
https://doi.org/10.1186/s40816-016-0032-5

Ita, B N., G.I. Ndukwe, G.I. 2017. Antioxidant Activity of Senna alata Root Extracts Ita Gloria Ihuoma NdukweGloria Ihuoma Ndukwe. Journal of Natural Products and Resources. 3(1):94-96

Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981− 2002. Journal of natural products. 2003;66(7):1022-37.
https://doi.org/10.1021/np030096l
PMid:12880330

Oladeji SO. Thin-layer chromatographic analysis of flavonoids and total phenolics in methanolic and ethanolic extracts of Senna alata (L.) Roxb.(Fabales: Fabaceae). Brazilian Journal of Biological Sciences. 2016;3(5):221-5.
https://doi.org/10.21472/bjbs.030520

Organization WH. General guidelines for methodologies on research and evaluation of traditional medicine. Geneva: World Health Organization, 2000.

Palanichamy S, Nagarajan S, Devasagayam M. Effect of Cassia alata leaf extract on hyperglycemic rats. Journal of ethnopharmacology. 1988;22(1):81-90.
https://doi.org/10.1016/0378-8741(88)90233-4

Paria N. Medicinal plant resources of south West Bengal: Research Wing, Directorate of Forests, Government of West Bengal, in collaboration with Department of Environment, Government of West Bengal; 2005.

Pieme C, Penlap V, Nkegoum B, Taziebou P, Tekwu E, Etoa F, et al. Evaluation of acute and subacute toxicities of aqueous ethanolic extract of leaves of Senna alata (L.) Roxb (Ceasalpiniaceae). African Journal of Biotechnology. 2006;5(3):283-9.

Ral P. Anthracene derivatives in leaves and fruits of Cassia alata. Current science. 1978.

Ral P. Anthracene derivatives in leaves and fruits of Cassia alata. Current science. 1978.

Ramasamy A, Balasundaram J, Rajappan M. Hepatoprotective activity of the alcoholic extract of the dried leaves of Cassia alata, Linn. Journal of pharmacy research. 2009;2(6):1107-9.

Roberson E. Nature's pharmacy, our treasure chest: Why we must conserve our natural heritage. Center for Biological Diversity. 2008.

Sagnia B, Fedeli D, Casetti R, Montesano C, Falcioni G, Colizzi V. Antioxidant and anti-inflammatory activities of extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva medicinal plants collected in Cameroon. PloS one. 2014;9(8):e103999.
https://doi.org/10.1371/journal.pone.0103999
PMid:25090613 PMCid:PMC4121200

Sharma P, Pandey D, Rizvi A, Gupta A. Antimicrobial activity of Cassia alata from Raipur region against clinical and MTCC isolates. Int J Curr Microbiol App Sci. 2015;4(1):330-9.

Varghese GK, Bose LV, Habtemariam S. Antidiabetic components of Cassia alata leaves: Identification through α-glucosidase inhibition studies. Pharmaceutical biology. 2013;51(3):345-9.
https://doi.org/10.3109/13880209.2012.729066
PMid:23137344

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