Comparative Antibiogram of Escherichia coli Isolated from the Urinary Tract Infection in Patients of Different Age and Sex Groups in Chittagong, Bangladesh
Md. Firoz Alam1, Maruf Abony1, Md. Suprio Sadat Sikdar1, Hasib Adnan1, Dilruba Akhter1, Kaniz Fatema1, Suvamoy Datta1*
Journal of Primeasia 1.2(1) 1-7 https://doi.org/10.25163/primeasia.1110008
Submitted: 01 February 2019 Revised: 13 December 2019 Published: 28 December 2019
Abstract
Background: Urinary tract infections (UTIs) are prevalent worldwide, with Escherichia coli (E. coli) responsible for over 85% of cases. Rising antibiotic resistance among UTI pathogens, largely due to antibiotic misuse, complicates treatment and demonstrates the need for regular resistance monitoring. Methods: This study investigated antibiotic resistance in E. coli isolates from 256 UTI patients, analyzing resistance to ten commonly prescribed antibiotics and assessing multidrug resistance (MDR) patterns across demographic groups. Results: E. coli was isolated in 15.63% of samples, showing high resistance to Cefuroxime (92%) and low resistance to Imipenem (5%), indicating Imipenem’s potential as an effective treatment. Overall, 72.5% of E. coli isolates were classified as MDR, with resistance to five or more antibiotics. Notably, young females and elder males exhibited the highest MDR rates (81.81%), suggesting demographic-specific resistance trends. Conclusion: This study showed the critical need for routine antibiograms to guide empirical therapy, as well as for improved antibiotic stewardship to limit resistance spread. Cefuroxime's high resistance rate suggests it may be ineffective in this patient group, whereas Imipenem and Nitrofurantoin may serve as better options. These findings emphasize the importance of targeted antimicrobial strategies and continuous surveillance to manage UTIs effectively in the face of growing antibiotic resistance. Future research should focus on understanding MDR drivers and developing novel treatments to improve UTI outcomes and mitigate the public health impact of resistant infections.
Keywords: Urinary tract infection (UTI), Escherichia coli (E. coli), Antibiotic resistance, Multidrug resistance (MDR), Empirical therapy
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