Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles in following topics:
- Molecular & Cellular Biomedicine
- Pharmacology & Drug Discovery
- Clinical & Translational Medic
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Integrative Biomedical Research
Table of Contents
Research Article
Pharmacology & Drug Discovery
Mohammed Abbas Al-Silaykhee1 , Saif Ddin Kadhoum Al-Zamili2 , Ahmed Ghdhban Al-Ziaydi1*
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
Abstract | Full Text |PDF (519 KB) | Open Access Article
Paulami Pal1, Subhabrata Ray2, Anup Kumar Das3, Manjir Sarma Kataki1, Saurav Dey4, Partha Pratim Dutta5, Tumpa Sarkar1, Mohini Singh1, Niva Rani Gogoi1, Bhaskar Mazumder1*
Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.
Abstract | Full Text |PDF (832 KB) | Open Access Article
Jeetendra Kumar Gupta 1*, N. Nagabhooshanam 2, Falah Hassan Shari 3, Venkatesan Hariram 4
This study showed NDDS as a promising strategy to improve the therapeutic potential of plant-derived drugs like curcumin.
Abstract | Full Text |PDF (165 KB) | Open Access Article
Synthesis, Characterization and Targeted Drug Delivery of Curcumin-Loaded PLGA Nanoparticles
Mohammad Chand Jamali1*, Amged Gaffer Mostafa Gaffer 1, Sameh Elsonbaty 1, Javed Yasin 2
This study revealed curcumin-loaded PLGA nanoparticles' potential to enhance bioavailability, stability, and therapeutic efficacy, supporting their application in targeted therapy and controlled release.
Abstract | Full Text |PDF (216 KB) | Open Access Article
Milk-Based Ointment Accelerates Wound Healing: A Comparative Study in Rabbits
Chiranjeev Singh 1*, Kunal Chandrakar 1
This study demonstrated that a 5% milk-based ointment significantly accelerated wound healing and improved tissue strength compared to conventional treatments in rabbits.
Abstract | Full Text |PDF (530 KB) | Open Access Article
Toxicological Assessment of Azo Dye Brown HT In Vivo
T M Tawabul Islam1, Nirmal Chandra Mahat2, Ivvala Anand Shaker3, Abul Kashem Tang2, Sheikh Arafat Rahman2, Mustakin Ahmed Shohel1, Inampudi Sailaja4*
This study demonstrated the adverse effects of azo dye Brown HT on juvenile health, underscoring the need for safer food practices to protect vulnerable populations.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Matazimov M.T. 1*, Sidametova Z.E. 1, Olimov N.K. 1, Abdullaeva M.U. 1, Rakhimova D.O. 1, Rustamov I. X. 1, Umurzakova N.S. 1
This study validates HPLC for accurately quantifying glycyrrhizic acid in FLEGMEN-SIP capsules, ensuring therapeutic compliance for neurological treatments.
Abstract | Full Text |PDF (376 KB) | Open Access Article
Hypoglycemic Action of Glycocar on Insulin and Glucose Metabolism In Vivo
Shonazarova Niginabonu Bobir qizi 1*, Fayzieva Ziyoda Turaevna 1, Zaribboyev Ma’rufjon Oybek o’gli 2, Tag’ayeva Muhayo Bafoevna 2
This study determined the Glycocar's potential to enhance insulin secretion, reduce hyperglycemia, and improve glucose metabolism, offering a promising alternative for diabetes management.
Abstract | Full Text |PDF (293 KB) | Open Access Article
Effect of Parasteron on In Vivo Atherosclerotic model with Functional and Tissue Damage Mitigation
Ghfran Adnan Abdul Amir 1*, Batool A. Hussein 2
Parasteron reduces atherosclerosis-related damage, suggesting potential as a therapeutic agent in managing cardiovascular disease.
Abstract | Full Text |PDF (739 KB) | Open Access Article
Chronic Toxic Effects of Chocolate Brown HT Dye on Hepatorenal Functions In Vivo
T M Tawabul Islam 1, Abul Kashem Tang 2, Inampudi Sailaja 3, Mustakin Ahmed Shohel 1, Sheikh Arafat Rahman 2, Nirmal Chandra Mahat 2, Ivvala Anand Shaker 4*
This study showed the gender-specific toxicological impacts of Chocolate Brown HT as safer food colorant practices and regulatory guidelines.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Nanotechnology-Enhanced Chemoradiotherapy Using Copper and Gold Nanoparticles for Esophageal Cancer
Keyan Zang1*
Nanotechnology might induce esophageal cancer treatment, enhancing patient outcomes with copper and gold nanoparticles boosting therapy efficacy and diagnostic precision.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Grape Juice on Paracetamol-Induced Hepatotoxicity and Nephrotoxicity
Andrew Johan 1*, Irene Uli 2, Yosefani Fortunella Yasmine 2
Grape juice elevates alanine transaminase and creatinine, exacerbating paracetamol toxicity. Caution advised when consuming paracetamol with grape juice.
Abstract | Full Text |PDF (191 KB) | Open Access Article
Embryotoxicity, Teratogenicity, and Chronic Toxicity of a Medicinal Balm with Adaptogenic Effects
Z.T. Fayzieva 1*, M. M. Rakhmatullayeva 1, G.O. Rakhimova 1, A.J.Rajapov 1, D. M. Hashirbaeva 1
Investigates medicinal balm's safety, showing no embryotoxic, teratogenic effects, or chronic toxicity, supporting its use in complex therapy.
Abstract | Full Text |PDF (374 KB) | Open Access Article
Fenugreek Induces The Sperm Characteristics in Hypothyroid Male Rats
Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1
This study demonstrated fenugreek's potential to improve sperm quality and hormone levels in hypothyroid male rats, suggesting therapeutic benefits.
Abstract | Full Text |PDF (270 KB) | Open Access Article
Ladi Alik Kumar 1, Gurudutta Pattnaik 1, Bhabani Sankar Satapathy2,*, Himansu Bhusan Samal 1, *
Glioma's high mortality and treatment challenges necessitate innovative strategies like nanoparticle-based drug delivery, enhancing therapy efficiency and prognosis.
Abstract | Full Text |PDF (912 KB) | Open Access Article
Rolla Al-Shalabi 1,2, Nozlena Abdul Samad 1*, Lim Vuanghao 1, Julia Joseph 1
The integration of Moringa oleifera nanoparticles and shea butter in lotion represents a groundbreaking milestone in skincare. This fusion offers profound benefits, including deep hydration and potent anti-inflammatory properties.
Abstract | Full Text |PDF (312 KB) | Open Access Article
Natural Colorants Induce the Drug Release from Fast Dissolving Tablets
Esra Tariq Bayrakdar 1, Sharad Visht 1*, Duran Kala 2, Saya Ameer 1, Ahmed Hamdy 1, Sawsan S. Al-Rawi 3, Samir Bhargava 4, Abhijeet Ojha 5
This study showed the impact of hydrophilic and hydrophobic colorants on drug release, crucial for improving palatability and therapeutic efficacy of fast dissolving tablets.
Abstract | Full Text |PDF (617 KB) |Supplementary Material | Open Access Article
Resveratrol Mitigates Acrylonitrile-induced Thyroid and Adrenal Toxicity in Rats
Samer I. Sabeeh 1*, Ahmed Q. Al-Awadi 1
Resveratrol counters acrylonitrile's adverse effects, preserving thyroid and adrenal function, evidenced hormonally and histologically, suggesting therapeutic potential.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Green Synthesis, Lead Toxicity and Pharmacokinetic Evaluation of Sumac Silver Nanoparticles In Vivo
Ammar H. Salman 1*, Mohammed Mosleh Shwaish 1
Sumac-synthesized silver nanoparticles (SAgNP) showed an eco-friendly approach to reduce blood lead levels, promising safer, cost-effective lead detoxification.
Abstract | Full Text |PDF (412 KB) | Open Access Article
Shirin Jazar Amin 1*, Ayyub J. Abdl-Rhmaan Al-Bayaty 1, Salah M. A. Alkubaisi 2
This study addressed the critical need for antidotes against benzene toxicity, highlighting Moringa oleifera's potential immunomodulatory effects.
Abstract | Full Text |PDF (210 KB) | Open Access Article
Ahmed Jassim Muklive Al-Ogaidi 1*, Hamssa Ahmed Easa 1, Shaymaa S. Hassan 1, Firas Al-Oqaili 1, Liblab S. Jassim 1
Spectrophotometric evaluation of sulphonamide using azo compounds offers a rapid, sensitive, and cost-effective method for quantitative pharmaceutical analysis.
Abstract | Full Text |PDF (506 KB) | Open Access Article
Synthesis, Characterization, and Antimicrobial Activity of Spiro Heterocyclic Compounds from Statin
Zubaida Amir Al-Heety 1, Ali Kareem Al-Nasseri 2*
The study elucidated the synthesis, structural characterization, and diverse biological activities of spiro heterocyclic compounds.
Abstract | Full Text |PDF (683 KB) |Supplementary Material | Open Access Article
Ghaida Fahad S Mubki 1, Mohmad Saad M Al Karani 1, Ahmed Saeed Abdullah 1, Tahani Mahmoud M Riyahi 1, Reem Abdulaziz Abdullah 1, Maha Mubarak Hamas Alotaibi 1, Amal Abdullah Faraj Hassan 2, Ahmed awad ali Zahrani 3, Nada Abdulrahman Hamad Altooq 1, Anfal Khalid Zain Bajamal 1, Nada saleh mohammad aldahaiman 1, Sajeda Qasim Abdulaziz Binjumaiah 1, Afaf Eesa Alsaggar Alenizi 1
Abstract | Full Text |PDF (341 KB) | Open Access Article
Nanoparticle-Mediated Plasmid Curing in Combating Antibiotic Resistance in Pathogenic Bacteria
Muntaha R. Ibraheem 1*, Dhafar N. Al-Ugaili 2
Novel approach fights antibiotic resistance. Enhances DNA extraction efficiency. Eliminates resistance plasmids, aiding biotechnology. Highlights research needs for nanoparticle optimization and mechanism understanding.
Abstract | Full Text |PDF (596 KB) | Open Access Article
Control Mycotoxin Contamination in Tarasas Food Using A Lab Fermantion
Baraa Jameel Al-Assil 1,2*, Taghreed Abed Wahwah 3
By utilizing LAB-mediated fermentation, this study demonstrated a natural and effective method for controlling mycotoxin contamination in traditional Tarasas food.
Abstract | Full Text |PDF (249 KB) | Open Access Article
Hussein Abdulkadhim Hasan 1*, Saad M. Mahdi 1, Hanaa Addai Ali 2
This study demonstrated the synthesis of Schiff bases, like azo-Schiff metal complexes, showing therapeutic effects.
Abstract | Full Text |PDF (583 KB) | Open Access Article
A Rapid Continuous Flow Injection Analysis Method Development for Diphenhydramine Hydrochloride
Asma A. Gayed Al-Ani 1* , Nagham S. Turkey Al-Awadie 1*
Novel flow injection analysis improves Diphenhydramine HCL detection in pharmaceuticals with high sensitivity, speed, simplicity, and cost-effectiveness, enhancing industrial efficiency.
Abstract | Full Text |PDF (801 KB) | Open Access Article
Farah M. Muhammad 1, Bushra A. Khairallah 1, K. A. Albadrany 1*
This study demonstrated a novel approach to the synthesis of oxazepine derivatives, key heterocyclic compounds with potential pharmacological applications.
Abstract | Full Text |PDF (650 KB) | Open Access Article
Synthesis, Characterization and Antibacterial Evaluation of Novel Thiazolidine Derivatives
Shaima H. Abdullah 1*, Mahmoud M. Salih 1, Khalid, A. Al-Badrany 1*
Thiazolidine derivatives, synthesized from heterocyclic compounds, exhibit diverse biological activities, including antibacterial effects against various bacterial strains, suggesting potential pharmaceutical applications.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Vitamin D In Modulating Liver And Kidney Functions Following Cadmium Exposure In Vivo
Ahmad Maher Ibrahim Al Sayeh 1, Walid Theib Mohammad 1*, Fernando Jesús Plaza del Pino 2
The research determined how vitamin D plays a vital part in relieving kidney and liver damage from cadmium, thus having important implications for treatment.
Abstract | Full Text |PDF (211 KB) | Open Access Article
Spectrophotometric Determination of Vitamin C Using Indirect Oxidation with a New Organic Dye
Asmaa Ahmed Mohammed Alrashidy 1, Omar Adnan Hashem 1, Kalid Abdul-Aziz ALBadrany 1
The research focuses on the indirect determination of vitamin C in various pharmaceutical formulations, as well as in natural fruit samples and commercially available juices. For the first time, a novel organic dye was utilized in the process, and it was found that the method was indeed effective for the quantification of vitamin C in these products.
Abstract | Full Text |PDF (448 KB) | Open Access Article
Efficacy of Paromomycin-Conjugated Nano Chitosan in Treating Entamoeba histolytica Infection in Mice
Hajar Falih Hishan Aldali 1*, Shatha Khudiar Abbas 1, Ahmed Naji Abd 1
Entamoeba histolytica causes widespread amebiasis. Chitosan-paromomycin nanoconjugates effectively treated infected mice, reducing liver enzyme levels, showing promising therapeutic potential.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Impact of Dapagliflozin on Atherosclerosis through Inflammation and Oxidative Pathways
Zainab Abdlkadhim Aboshnin 1*, Safa Azhar Razzaq 1, Zahraa Ibraheim Jawad Shubber 2
Atherosclerotic patients need therapies targeting inflammation and oxidation. This study supports Dapagliflozin's use for clinical benefits in atherosclerosis.
Abstract | Full Text |PDF (360 KB) | Open Access Article
Anwar Shalan F. 1*, Samah Hussein Kadhim 1
Anti-cancer activity of Gemini surfactants in human breast cancer cells
Abstract | Full Text |PDF (1 MB) | Open Access Article
Sarhan Rashid Sarhan 1*, Mohammed H.M. Merah 2
ALP, ALT and AST enzymes increased significantly when directly exposed to this pesticide as a result of its effect on kidney and liver functions.
Abstract | Full Text |PDF (436 KB) | Open Access Article
Jenan Mahdi Jawad Al-kawaz 1*, Fakhir Magtoof Al-Zubaidy 2**, Hussein Jassim Obaid Al -Harbi 1***
Evaluate the healing effects of esomeprazole, curcumin, chitosan, and a curcumin-chitosan mixture on gastric injuries induced by ethanol in rats.
Abstract | Full Text |PDF (737 KB) | Open Access Article
Rozhan Arif 1, Sharad Visht 1*, Ali Omar Yassen 1, Sana Sirwan Salih 1
Formulating ketotifen fast-dissolving tablets (FDT) tackled poor bioavailability challenges, emphasizing sodium bicarbonate's pivotal role for rapid tablet disintegration, highlighting FDT viability for asthmatic treatment.
Abstract | Full Text |PDF (556 KB) | Open Access Article
Mukhlif Mohsin Slaihim 1*, Luay Ali Dhahi 1, Abeer Hussein Ali 1
Introduced piperidine-catalyzed protection in aldehydes, guiding anti-cancer compound optimization.
Abstract | Full Text |PDF (804 KB) |Supplementary Material | Open Access Article
Gymnemagenin a Promising Drug Candidate for Management of Hyperglycemia: In-Vitro and In-Vivo Study
Javed Ahamad1, Saima Amin2, Kamran J Naquvi1, Showkat R Mir3*
Study of Gymnema sylvestre plant for the treatment and management of diabetes.
Abstract | Full Text |PDF (349 KB) | Open Access Article
Effect of Plumbago zeylanica on Analgesia and Arthritis
Subasini Uthirapathy1*
The inhibition activity of PZ on carrageenan-induced arthritis, humoral and cellular immunity, and pain and inflammation.
Abstract | Full Text |PDF (225 KB) | Open Access Article
Abeer Hussein Alia, and Mukhlif Mohsin Slaihimb*.
Antibacterial efficacy of new chemical compounds named benzaldehyde derivatives.
Abstract | Full Text |PDF (532 KB) | Open Access Article
Ben Enoluomen Ehigiator1, SamuelKelechi Mobisson2, Iheanyichukwu Wopara3*, Chinonye Cynthia Chibuife1, Uwaezuoke Chukwuekele Awarajih3, Harrison Ogheneochuko Eruotor3
Abstract | Full Text |PDF (521 KB) | Open Access Article
Hana Bali1, Jun Qing Yu1, Philip Beale2, and Fazlul Huq3
Ox in combination Cur demonstrated very high synergism against HT-29 and Caco-2 cell lines.
Abstract | Full Text |PDF (1002 KB) | Open Access Article
Md Shamsuddin Sultan Khan A,C,E, Mohammad Adnan Iqbal B, Muhammad Asif A, Tabinda Azam B, Majed Al-Mansoub A, Rosenani S. M. A. Haque B, Mohammed Khadeer Ahamed Basheer C, Aman Shah Abdul Majid D, Amin Malik Shah Abdul Majid A,C,E*
Metal salts and base rosmarinates demonstrated potent anti-GBM efficacy as IL17A inhibitor with minimal toxicity.
Abstract | Full Text |PDF (1 MB) |Supplementary Material | Open Access Article
Mansoureh Nazari Vishkaei a, Mohamed Khadeer Ahamed Basheer c, Amin Malik Shah Abdul Majid a,b
SLOS vesicles can be considered for effective dermal therapeutic agent for the treatment of skin cancer.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Reviews
Pharmacology & Drug Discovery
Nahid Amin1*, Papiya Sultana Sharker Sharna1
AI compresses AMR diagnosis and discovery timelines dramatically, yet no tool has reached regulatory clearance — validation and trust, not algorithms, remain the bottleneck.
Abstract | Full Text |PDF (587 KB) | Open Access Article
Integrating Genomics, Transcriptomics, and Organoid-Based Drug Testing for Precision Cancer Care
Yoghinni Manogaran 1*, Ahmed Ahmed Al-Akwaa 2
Integrating transcriptomic, epigenetic, and functional organoid data with genomics may finally close oncology’s persistent gap between diagnosis and matched treatment.
Abstract | Full Text | Open Access Article
Mohammad Lutfor Rahman1*
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
Abstract | Full Text |PDF (729 KB) | Open Access Article
Nazmun Nahar 1, 2*
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
Abstract | Full Text |PDF (296 KB) | Open Access Article
Mohammad Lutfor Rahman1*, Md Al Mamun2, Ahad Ahamed3, Mohosin Kabir4, Faranak Nadarkhani Dinehkaboudi4, Marziyeh Zangeneh4, Md. Nezab Uddin5, AHM Quamruzzaman6
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
Abstract | Full Text |PDF (565 KB) | Open Access Article
Dipanjan Koley1, Vaibhav Walia2, Mohammed. Aslam3, Manvi Singh4*
Developing pegylated liposomal teriflunomide may enhance breast cancer treatment efficacy, reduce side effects, and improve patient outcomes.
Abstract | Full Text |PDF (426 KB) | Open Access Article
Mohosin Kabir 1*, Nadimbhai Salimbhai Vahora 1
This review discusses the importance of tailored tablet coatings to optimize drug release, stability, bioavailability, and therapeutic efficacy.
Abstract | Full Text |PDF (414 KB) | Open Access Article
Mohosin Kabir 1*, Md. Refayet Hossen Rana 2, Arnab Debnath 3
This study highlights the role of Quality Assurance in ensuring product integrity, patient safety, and driving pharmaceutical innovation.
Abstract | Full Text |PDF (334 KB) | Open Access Article
Disrupting Bacterial Biofilms to Combat Dental Diseases Using Nanotechnology in Oral Healthcare
Hunny Dabas1, Faraat Ali2, Fairy3, Khushi Quadri1, Manshi Dangi1, Parween Jamil4, Mohammed Aslam5, Manvi Singh1*
This review discusses the use of nanoparticles as innovative solutions for disrupting bacterial oral biofilms, enhancing antimicrobial efficacy, and revolutionizing oral healthcare with minimal resistance.
Abstract | Full Text |PDF (673 KB) | Open Access Article
Balisa Mosisa Ejeta1*, Malay K Das1, Sanjoy Das1
This study showed advanced nanotechnology-based paclitaxel delivery systems, offering enhanced cancer targeting, reduced side effects, and potential solutions to drug resistance.
Abstract | Full Text |PDF (174 KB) | Open Access Article
Mohd. Javed Naim 1*
This review highlights the therapeutic potential of quinazoline derivatives in cancer treatment, focusing on their ability to target critical tyrosine kinases and offering insights into their development as effective anticancer agents.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Advances in SGLT2 Inhibitors for Type 2 Diabetes Management
Mohd. Javed Naim 1*
This review highlights novel SGLT2 inhibitors, emphasizing their potential in enhancing therapeutic options for type 2 diabetes management.
Abstract | Full Text |PDF (933 KB) | Open Access Article
Emerging Lipid-Lowering Therapies: A Comprehensive Review of Novel Agents Targeting Hyperlipidemia
Subasini Uthirapathy 1*
This review provides innovative therapies targeting lipid metabolism, offering personalized options to improve outcomes in hyperlipidemia management.
Abstract | Full Text |PDF (419 KB) | Open Access Article
Transformative Role of Artificial Intelligence in the Pharmaceutical Sector
Balisa Mosisa Ejeta*1, Malay K Das2*, Sanjoy Das3, Fetene Fufa Bekere4, Dubom Tayeng5
This review highlights AI's potential to revolutionize drug discovery, development, and regulatory processes, improving patient outcomes and healthcare efficiency.
Abstract | Full Text |PDF (182 KB) | Open Access Article
Rabi Sankar Mondal1*, Lamia Akter2, Md Nazmul Alam Bhuiyan1
AI is revolutionizing drug development by accelerating discoveries and creating more personalized treatments, thereby making healthcare more efficient for everyone.
Abstract | Full Text |PDF (335 KB) | Open Access Article
Recent Advances in Paclitaxel Drug Delivery: Challenges, Innovations, and Future Directions
Balisa Mosisa Ejeta 1*, Malay K Das 1*, Sanjoy Das 1
This review addresses advancements in paclitaxel drug delivery, emphasizing innovative methods to enhance efficacy and combat resistance.
Abstract | Full Text |PDF (700 KB) | Open Access Article
Anastasia V. Poznyak 1*, Alexey V. Churov 2,3, Irina Alexandrovna Starodubtseva 4, Natalia V. Elizova 2, Tatiana Ivanovna Kovyanova 1,3, Vasily N. Sukhorukov 3, and Alexander N. Orekhov 3
This review describes the understanding of atherosclerosis through animal models aids in revealing disease mechanisms, testing treatments, and improving therapeutic strategies for humans.
Abstract | Full Text |PDF (968 KB) | Open Access Article
A Comprehensive Review of the Pharmacology of Statins and its Clinical Implications
Athiban Inbarajan 1*, Giri GVV 2, Anusha D 3, Alan Mathew Punnoose 4, Jasline David J 5, Mubeena S 6
The study aims to provide a detailed understanding of statins, their pharmacodynamics, and the various types involved as beneficial agents in the treatment of bone resorption and hypercholesterolemia.
Abstract | Full Text |PDF (355 KB) | Open Access Article
Hunny Dabas 1, Deepika Singh 1, Faraat Ali 2, Dipanjan Koley 1, Mohammed. Aslam 3, Esra Tariq Anwer Bayrakdar 3, Manvi Singh 1*
This review comprehensively discusses the transdermal drug delivery systems (TDDS) in the area of drug administration, for non-invasive, precise, and efficient delivery, overcoming oral limitations.
Abstract | Full Text |PDF (536 KB) | Open Access Article
Repurposing Drugs for Overcoming Therapy Resistance in Colon Cancer – A Review
Mahdi Darvishi 1, Amir Mohammad Chekeni 2, Mohammad Fazelhosseini 1, Zeenat Iqbal 3*, Mohd Aamir Mirza 3*, Mohammed Aslam 4, Esra Tariq Anwer Bayrakdar 4
Oncology research seeks new therapies for aggressive CRC, utilizing repurposed drugs for accelerated and safer treatment approaches.
Abstract | Full Text |PDF (842 KB) | Open Access Article
Prachi Gurudiwan 1*, Ragini Patel 1, Urvashi Jain 1
Quantitative Systems Pharmacology models immune processes in breast cancer, aiding personalized treatment by identifying biomarkers, resistance mechanisms, and therapeutic options
Abstract | Full Text |PDF (1 MB) | Open Access Article
Chandrapratap Dhimar 1*, Krishna Sahu 1, Moniza Nurez Khan 1
Utilizing innovative postbiotics and Simvastatin Polymeric Nanoparticles, wound research accelerates healing, promising improved treatment with minimal inflammation.
Abstract | Full Text |PDF (652 KB) | Open Access Article
Machine Learning-Based Enhanced Drug Delivery System and Its Applications – A Systematic Review
Abhijeet Madhukar Haval 1*, Kumar Shwetabh 1, Sushree Sasmita Dash 1
Machine Learning (ML) transforms drug development, predicting drug properties, targets, interactions, and facilitating efficient exploration for researchers and pharmaceutical companies.
Abstract | Full Text |PDF (528 KB) | Open Access Article
Curcumin Nanocarriers with a Focus on Cellular Uptake Studies – An Innovative Cancer Therapy
Kalpita Bhatta 1, Pratikshya Mohanty 1, Itishree Jogamaya Das 2, Himansu Bhusan Samal *3
Using curcumin nanocarriers could provide several benefits in combating cancers
Abstract | Full Text |PDF (648 KB) | Open Access Article
Mohd. Javed Naim 1
To establish potential DPP-4 inhibitors.
Abstract | Full Text |PDF (756 KB) | Open Access Article
Lakhan Lal Kashyap 1, Harish Jaiswal 2
A targeted drug delivery approach, using double-imprinted nanoparticles and EGFR-SVM, to enhance anticancer drug effectiveness selectively in tumor cells.
Abstract | Full Text |PDF (446 KB) | Open Access Article
Hydrophobin-Coated Noisomes as Drug Carriers in Lung Cancer Cells - A Review
Srishti Namdeo 1, Chandrapratap Dhimar 2
Targeted nanoparticle delivery to Lung Cancer Cells, using hydrophobin-coated niosomes, addressing multidrug resistance, and enhancing treatment efficacy.
Abstract | Full Text |PDF (880 KB) | Open Access Article
Poorti Sharma 1*, Lukeshwari Sahu 1
Study explores Cannabis use by metastatic tumor patients, analyzing active components, addressing gaps in research, and promoting informed medical guidance.
Abstract | Full Text |PDF (769 KB) | Open Access Article
Sanjay Kumar Mire 1, Deepak Kumar Sahu 2
Echocardiography-based strain imaging offers early detection of cardiac abnormalities, treatment, and research strategy.
Abstract | Full Text |PDF (951 KB) | Open Access Article
Aman Chandrakar 1, Chetan Kumar Sonkar 2
The cancer treatment will be accelerated through drug repositioning.
Abstract | Full Text |PDF (1 MB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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RETRACTED ARTICLE: Predicting Parkinson’s Disease Progression Using Statistical And Neural Mixed Effects Models: Comparative Study On Longitudinal Biomarkers
This study demonstrates interpretable, robust modeling for Parkinson’s telemonitoring, guiding reliable disease progression prediction under small-sample longitudinal data constraints.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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An Integrated AI-Driven Framework for Maternal Resource Intelligence Shortages Across U.S. Hospital
Integrating predictive analytics, reinforcement learning, and causal inference improves maternal outcomes by aligning risk prediction with real-time, equity-aware resource allocation decisions.
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Serum Uric Acid Reduction Following Use of Canssu5®, a Standardized Orthosiphon stamineus Extract, in Adults with Hyperuricemia: A Retrospective Case Study
This study provides preliminary clinical evidence that standardized Orthosiphon stamineus extract may meaningfully reduce serum uric acid in hyperuricemic adults.
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Comprehensive Review of Foundation Toxicity Models Integrating In Vivo, In Vitro, and Chemical Knowledge for Unified Risk Prediction
Bridges experimental and computational toxicology to enable predictive, human-relevant risk assessment frameworks for safer and faster chemical evaluation
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Integrative Molecular and Microbial Mechanisms Linking Liver Fibrosis, Cancer Biology, and Host-Microbe Interactions
This study integrates biomedical and ecological research, revealing shared biological mechanisms that inform therapeutic innovation, sustainable agriculture, and systems-level understanding of complex biological interactions.
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Dietary Bioactive Compounds in Cancer and Cardiovascular Health: A Systematic Review of Methylxanthines, Polyphenols, and Flavonoids
This study demonstrates that dietary bioactive compounds play a significant role in reducing the risk of chronic diseases, improving cardiovascular health, and offering protective effects against certain types of cancer.
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Therapeutic Angiogenesis: From Single-Factor Failures to Precision Vascular Regeneration
Multimodal, precision-guided angiogenic therapies—gene, cell, extracellular vesicle, and biomaterial-based—offer transformative potential for treating ischemic diseases where revascularization remains unfeasible.
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Epigenetic Clocks and Biological Ageing: From Biomarker to Intervention Target
Epigenetic clocks convert DNA methylation into a modifiable biomarker, repositioning ageing as a treatable clinical target.
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Mapping the Invisible Architecture of Disease: Spatial Multi-Omics Technologies, Computational Integration, and the Path Toward Clinical Translation
Spatial multi-omics repositions tissue context as a first-class clinical variable, but equitable, standardized translation remains unfinished business.
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Why Artificial Intelligence Models for Antimicrobial Resistance Still Fail at the Bedside: A Review of Validation, Explainability, and Equity Gaps
Explains why highly accurate AI resistance models fail clinically, and outlines concrete validation, equity, and deployment fixes.
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Single-Cell and Spatial Transcriptomics in Precision Diagnostics: A Roadmap for Clinical Adoption
Spatial transcriptomics reveals disease architecture at cellular resolution, but cost, FFPE limits, and complexity keep it from routine clinical diagnostics.
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From Days to Hours: Artificial Intelligence in Antimicrobial Resistance Diagnostics and Drug Discovery, and Why No Tool Has Yet Reached the Clinic
AI compresses AMR diagnosis and discovery timelines dramatically, yet no tool has reached regulatory clearance — validation and trust, not algorithms, remain the bottleneck.
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The Gut–Brain–Immune Axis in Chronic Disease: Mechanisms and Therapeutic Opportunities — A Narrative Synthesis
This review reframes chronic neurodegenerative and autoimmune disease through a reproducible, microbiome-centered mechanistic and therapeutic lens.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.
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Extracellular Vesicles as Diagnostic and Therapeutic Tools: Closing the Translational Gap
Extracellular vesicles promise cell-free precision diagnostics and therapeutics, but standardization, scalability, and regulatory gaps still block routine clinical adoption.
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Senescent Cell Heterogeneity and Precision Clearance Strategies: From Molecular Mechanism to Clinical Translation
Mapping senescent-cell heterogeneity to precision senotherapies could transform multimorbid, age-related disease treatment safely
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Obesity Pharmacotherapy in the GLP-1 Era: Efficacy, Equity, and the Long-Term Unknowns of Incretin-Based Care
Bariatric-level pharmacotherapy now exists, yet muscle loss, rebound, cost, and pediatric uncertainty still limit its real-world promise.
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Organoid-on-Chip Platforms as Predictive Models of Human Disease: Promise and Pitfalls
Organoid-on-chip systems merge biological fidelity with engineering precision, offering AI-augmented, human-relevant platforms positioned to reshape preclinical drug development.
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Mitochondrial Transfer Between Cells: Physiological Roles and Therapeutic Potential
Intercellular mitochondrial transfer sustains tissue bioenergetics and immunity, offering a transformative, biologically grounded therapeutic strategy for degenerative and ischemic disease.
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Tissue-Resident Memory T Cells in Health and Disease: Emerging Regulators of Immunity
Tissue-resident memory T cells permanently guard peripheral organs, but their dysregulation drives chronic autoimmune disease, making them a precise emerging therapeutic target.
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Multimorbidity in Ageing Populations: Redefining Clinical Guidelines for Combined Disease Management
Frailty-based, mechanism-anchored prescribing frameworks could replace single-disease guidelines that quietly harm complex older patients.
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Long COVID as a Network Disorder: Mechanisms, Biomarkers, and the Path Toward Mechanism-Anchored Clinical Stratification
Reframing Long COVID as a biologically stratifiable network disorder could finally make targeted, effective treatment trials possible.
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Emerging CRISPR-Cas, Antibody, and Nanomedicine Strategies Against Antimicrobial Resistance in Critical Care
AMR is outpacing critical-care antibiotics; precision genomic, antibody, peptide, and nanozyme strategies may restore therapeutic options.
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Integrating Genomics, Transcriptomics, and Organoid-Based Drug Testing for Precision Cancer Care
Integrating transcriptomic, epigenetic, and functional organoid data with genomics may finally close oncology’s persistent gap between diagnosis and matched treatment.
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Digital Biomarkers and Wearable Bioelectronics Across Neurological, Cardiopulmonary, and Mental Health Conditions: Clinical Evidence and Barriers to Adoption
Wearable digital biomarkers show strong clinical validity but require standardized validation, interoperable data systems, and equitable design before routine adoption.
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Modifiable Triggers and Autoimmune Disease Flares: A Mechanistic and Clinical Synthesis of Molecular Mimicry, Barrier Disruption, and Neuroendocrine-Microbial Crosstalk
Environmental exposures converge with genetic risk to trigger autoimmune flares, guiding precision prevention beyond genetics alone.
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Artificial Intelligence in Precision Cardiovascular Medicine: Risk Prediction, Digital Twins, and Explainability
Artificial-intelligence risk models and digital twins could shift cardiology from reactive treatment toward proactive, individualized prevention — if bias, validation, and trust gaps are honestly addressed.
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Moving Beyond the Double-Strand Break Through CRISPR-Based Epigenome Editing for Specificity-Driven Sickle Cell Disease Therapy
Epigenome editing may silence sickle-globin defects without DNA cleavage, offering a safer, durable alternative to nuclease-based gene therapy.
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Non-Coding RNA Networks in Pancreatic Ductal Adenocarcinoma: An Expanding Regulatory Landscape from the ceRNA TRIAD to Exosomal Immune Evasion and Ferroptosis Escape
Non-coding RNA networks orchestrate pancreatic cancer progression, immune evasion, and chemoresistance, revealing druggable nodes for precision therapy.
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Liquid–Liquid Phase Separation as a Unifying Biophysical Driver of Proteinopathy in ALS and Frontotemporal Dementia: Mechanisms, Molecular Grammar, and Therapeutic Vulnerabilities
Mapping how ALS/FTD proteins phase-separate and solidify reveals shared biophysical vulnerabilities that could be therapeutically exploited across the disease spectrum.
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RNA Modifications Reprogram the Epitranscriptome to Drive Hepatocellular Carcinoma Progression
RNA modifications reprogram liver-cancer transcripts to drive growth, immune escape, and drug resistance—offering new biomarkers and druggable targets.
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Protein Language Models for Predicting BRCA1/BRCA2 Variant Pathogenicity: A Computational Bridge Toward Precision Oncology
Protein language models can resolve uncertain BRCA variants rapidly, potentially widening equitable access to PARP-inhibitor therapy worldwide.
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Chromatin Architecture Disruption Drives Transcriptional Dysregulation and Reveals Therapeutic Vulnerabilities in Acute Myeloid Leukaemia
STAG2/cohesin loss and oncofusion proteins collapse 3D chromatin loops in AML, silencing differentiation genes while revealing druggable, reversible epigenetic vulnerabilities.
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Cellular Senescence as a Pathogenic Hub Driving Mechanistic Networks and Reversal Strategies in Idiopathic Pulmonary Fibrosis
Cellular senescence organizes IPF pathogenesis across cell types, positioning senotherapeutics and regenerative cell therapy as biologically grounded strategies for reversing, not merely slowing, fibrosis.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.