Integrative Biomedical Research

Integrative Biomedical Research (Journal of Angiotherapy) | Online ISSN  3068-6326
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Integrative Biomedical Research

Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles in following topics:

  • Molecular & Cellular Biomedicine
  • Pharmacology & Drug Discovery
  • Clinical & Translational Medic
More +
Editor-in-Chief: Fazlul Huq, Ph.D.

Article

Integrative Biomedical Research

Table of Contents


Research Article

Pharmacology & Drug Discovery

Research Article | Pharmacology & Drug Discovery
Published online 18 May 2025

Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications

Mohammed Abbas Al-Silaykhee1 , Saif Ddin Kadhoum Al-Zamili2 , Ahmed Ghdhban Al-Ziaydi1*

Integrative Biomedical Research
Views: 1920 | Downloads: 32

This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.

Abstract | Full Text |PDF (519 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 31 December 2024

Lung-Targeted Solid Lipid Nanoparticles for Enhanced Pulmonary Delivery of Anti-Tubercular Drugs: A Novel Approach to Improve Bioavailability

Paulami Pal1, Subhabrata Ray2, Anup Kumar Das3, Manjir Sarma Kataki1, Saurav Dey4, Partha Pratim Dutta5, Tumpa Sarkar1, Mohini Singh1, Niva Rani Gogoi1, Bhaskar Mazumder1*

Integrative Biomedical Research
Views: 2641 | Downloads: 84

Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.

Abstract | Full Text |PDF (832 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 15 October 2024

Curcumin Nanostructured Drug Delivery Induces the Anti-cancer and Anti-inflammatory activity In Vitro and In Vivo

Jeetendra Kumar Gupta 1*, N. Nagabhooshanam 2, Falah Hassan Shari 3, Venkatesan Hariram 4

Integrative Biomedical Research
Views: 2074 | Downloads: 24

This study showed NDDS as a promising strategy to improve the therapeutic potential of plant-derived drugs like curcumin.

Abstract | Full Text |PDF (165 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 11 October 2024

Synthesis, Characterization and Targeted Drug Delivery of Curcumin-Loaded PLGA Nanoparticles

Mohammad Chand Jamali1*, Amged Gaffer Mostafa Gaffer 1, Sameh Elsonbaty 1, Javed Yasin 2

Integrative Biomedical Research
Views: 3237 | Downloads: 137

This study revealed curcumin-loaded PLGA nanoparticles' potential to enhance bioavailability, stability, and therapeutic efficacy, supporting their application in targeted therapy and controlled release.

Abstract | Full Text |PDF (216 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 10 September 2024

Milk-Based Ointment Accelerates Wound Healing: A Comparative Study in Rabbits

Chiranjeev Singh 1*, Kunal Chandrakar 1

Integrative Biomedical Research
Views: 2432 | Downloads: 12

This study demonstrated that a 5% milk-based ointment significantly accelerated wound healing and improved tissue strength compared to conventional treatments in rabbits.

Abstract | Full Text |PDF (530 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 14 August 2024

Toxicological Assessment of Azo Dye Brown HT In Vivo

T M Tawabul Islam1, Nirmal Chandra Mahat2, Ivvala Anand Shaker3, Abul Kashem Tang2, Sheikh Arafat Rahman2, Mustakin Ahmed Shohel1, Inampudi Sailaja4*

Integrative Biomedical Research
Views: 2664 | Downloads: 47

This study demonstrated the adverse effects of azo dye Brown HT on juvenile health, underscoring the need for safer food practices to protect vulnerable populations.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 13 August 2024 5678.jpg?638744273615631215

Quantification of Glycyrrhizic Acid in FLEGMEN-SIP Capsules Using High-Performance Liquid Chromatography for CNS Disorders

Matazimov M.T. 1*, Sidametova Z.E. 1, Olimov N.K. 1, Abdullaeva M.U. 1, Rakhimova D.O. 1, Rustamov I. X. 1, Umurzakova N.S. 1

Integrative Biomedical Research
Views: 2504 | Downloads: 21

This study validates HPLC for accurately quantifying glycyrrhizic acid in FLEGMEN-SIP capsules, ensuring therapeutic compliance for neurological treatments.

Abstract | Full Text |PDF (376 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 15 July 2024

Hypoglycemic Action of Glycocar on Insulin and Glucose Metabolism In Vivo

Shonazarova Niginabonu Bobir qizi 1*, Fayzieva Ziyoda Turaevna 1, Zaribboyev Ma’rufjon Oybek o’gli 2, Tag’ayeva Muhayo Bafoevna 2

Integrative Biomedical Research
Views: 2335 | Downloads: 34

This study determined the Glycocar's potential to enhance insulin secretion, reduce hyperglycemia, and improve glucose metabolism, offering a promising alternative for diabetes management.

Abstract | Full Text |PDF (293 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 08 July 2024

Effect of Parasteron on In Vivo Atherosclerotic model with Functional and Tissue Damage Mitigation

Ghfran Adnan Abdul Amir 1*, Batool A. Hussein 2

Integrative Biomedical Research
Views: 2024 | Downloads: 10

Parasteron reduces atherosclerosis-related damage, suggesting potential as a therapeutic agent in managing cardiovascular disease.

Abstract | Full Text |PDF (739 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 07 July 2024

Chronic Toxic Effects of Chocolate Brown HT Dye on Hepatorenal Functions In Vivo

T M Tawabul Islam 1, Abul Kashem Tang 2, Inampudi Sailaja 3, Mustakin Ahmed Shohel 1, Sheikh Arafat Rahman 2, Nirmal Chandra Mahat 2, Ivvala Anand Shaker 4*

Integrative Biomedical Research
Views: 2987 | Downloads: 46

This study showed the gender-specific toxicological impacts of Chocolate Brown HT as safer food colorant practices and regulatory guidelines.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 21 June 2024

Nanotechnology-Enhanced Chemoradiotherapy Using Copper and Gold Nanoparticles for Esophageal Cancer

Keyan Zang1*

Integrative Biomedical Research
Views: 1973 | Downloads: 21

Nanotechnology might induce esophageal cancer treatment, enhancing patient outcomes with copper and gold nanoparticles boosting therapy efficacy and diagnostic precision.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 17 June 2024

Grape Juice on Paracetamol-Induced Hepatotoxicity and Nephrotoxicity

Andrew Johan 1*, Irene Uli 2, Yosefani Fortunella Yasmine 2

Integrative Biomedical Research
Views: 3572 | Downloads: 25

Grape juice elevates alanine transaminase and creatinine, exacerbating paracetamol toxicity. Caution advised when consuming paracetamol with grape juice.

Abstract | Full Text |PDF (191 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 21 May 2024

Embryotoxicity, Teratogenicity, and Chronic Toxicity of a Medicinal Balm with Adaptogenic Effects

Z.T. Fayzieva 1*, M. M. Rakhmatullayeva 1, G.O. Rakhimova 1, A.J.Rajapov 1, D. M. Hashirbaeva 1

Integrative Biomedical Research
Views: 2154 | Downloads: 12

Investigates medicinal balm's safety, showing no embryotoxic, teratogenic effects, or chronic toxicity, supporting its use in complex therapy.

Abstract | Full Text |PDF (374 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 21 May 2024

Fenugreek Induces The Sperm Characteristics in Hypothyroid Male Rats

Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1

Integrative Biomedical Research
Views: 3692 | Downloads: 11

This study demonstrated fenugreek's potential to improve sperm quality and hormone levels in hypothyroid male rats, suggesting therapeutic benefits.

Abstract | Full Text |PDF (270 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 14 May 2024

Advances in Targeted Glioma Therapy with Transferrin-Conjugated Gemcitabine-Loaded PLGA Nanoparticles

Ladi Alik Kumar 1, Gurudutta Pattnaik 1, Bhabani Sankar Satapathy2,*, Himansu Bhusan Samal 1, *

Integrative Biomedical Research
Views: 2775 | Downloads: 21

Glioma's high mortality and treatment challenges necessitate innovative strategies like nanoparticle-based drug delivery, enhancing therapy efficiency and prognosis.

Abstract | Full Text |PDF (912 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 22 April 2024

Advancing Lotion Formulation Research: Harnessing the Potential of Moringa oleifera and Shea Butter for Enhanced Skin Health

Rolla Al-Shalabi 1,2, Nozlena Abdul Samad 1*, Lim Vuanghao 1, Julia Joseph 1

Integrative Biomedical Research
Views: 3550 | Downloads: 57

The integration of Moringa oleifera nanoparticles and shea butter in lotion represents a groundbreaking milestone in skincare. This fusion offers profound benefits, including deep hydration and potent anti-inflammatory properties.

Abstract | Full Text |PDF (312 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 12 April 2024

Natural Colorants Induce the Drug Release from Fast Dissolving Tablets

Esra Tariq Bayrakdar 1, Sharad Visht 1*, Duran Kala 2, Saya Ameer 1, Ahmed Hamdy 1, Sawsan S. Al-Rawi 3, Samir Bhargava 4, Abhijeet Ojha 5

Integrative Biomedical Research
Views: 2682 | Downloads: 30

This study showed the impact of hydrophilic and hydrophobic colorants on drug release, crucial for improving palatability and therapeutic efficacy of fast dissolving tablets.

Abstract | Full Text |PDF (617 KB) |Supplementary Material | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 09 April 2024

Resveratrol Mitigates Acrylonitrile-induced Thyroid and Adrenal Toxicity in Rats

Samer I. Sabeeh 1*, Ahmed Q. Al-Awadi 1

Integrative Biomedical Research
Views: 2292 | Downloads: 11

Resveratrol counters acrylonitrile's adverse effects, preserving thyroid and adrenal function, evidenced hormonally and histologically, suggesting therapeutic potential.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 08 April 2024

Green Synthesis, Lead Toxicity and Pharmacokinetic Evaluation of Sumac Silver Nanoparticles In Vivo

Ammar H. Salman 1*, Mohammed Mosleh Shwaish 1

Integrative Biomedical Research
Views: 2159 | Downloads: 15

Sumac-synthesized silver nanoparticles (SAgNP) showed an eco-friendly approach to reduce blood lead levels, promising safer, cost-effective lead detoxification.

Abstract | Full Text |PDF (412 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 07 April 2024

Immunomodulatory Effects of Moringa oleifera Seed Extract and Nano Zinc Oxide on Benzene-Induced Toxicity In-Vivo

Shirin Jazar Amin 1*, Ayyub J. Abdl-Rhmaan Al-Bayaty 1, Salah M. A. Alkubaisi 2

Integrative Biomedical Research
Views: 2261 | Downloads: 7

This study addressed the critical need for antidotes against benzene toxicity, highlighting Moringa oleifera's potential immunomodulatory effects.

Abstract | Full Text |PDF (210 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 06 April 2024

Ultra Micro Determination of Sulphonamide Through Oxidative Coupling Reaction Using Diazotized Promethazine

Ahmed Jassim Muklive Al-Ogaidi 1*, Hamssa Ahmed Easa 1, Shaymaa S. Hassan 1, Firas Al-Oqaili 1, Liblab S. Jassim 1

Integrative Biomedical Research
Views: 2195 | Downloads: 12

Spectrophotometric evaluation of sulphonamide using azo compounds offers a rapid, sensitive, and cost-effective method for quantitative pharmaceutical analysis.

Abstract | Full Text |PDF (506 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 05 April 2024

Synthesis, Characterization, and Antimicrobial Activity of Spiro Heterocyclic Compounds from Statin

Zubaida Amir Al-Heety 1, Ali Kareem Al-Nasseri 2*

Integrative Biomedical Research
Views: 3310 | Downloads: 48

The study elucidated the synthesis, structural characterization, and diverse biological activities of spiro heterocyclic compounds.

Abstract | Full Text |PDF (683 KB) |Supplementary Material | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 02 April 2024

Comparing Apixaban vs Rivaroxaban for Atrial Fibrillation Patients: An Effectiveness and Safety Analysis

Ghaida Fahad S Mubki 1, Mohmad Saad M Al Karani 1, Ahmed Saeed Abdullah 1, Tahani Mahmoud M Riyahi 1, Reem Abdulaziz Abdullah 1, Maha Mubarak Hamas Alotaibi 1, Amal Abdullah Faraj Hassan 2, Ahmed awad ali Zahrani 3, Nada Abdulrahman Hamad Altooq 1, Anfal Khalid Zain Bajamal 1, Nada saleh mohammad aldahaiman 1, Sajeda Qasim Abdulaziz Binjumaiah 1, Afaf Eesa Alsaggar Alenizi 1

Integrative Biomedical Research
Views: 3605 | Downloads: 31

Abstract | Full Text |PDF (341 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 23 March 2024

Nanoparticle-Mediated Plasmid Curing in Combating Antibiotic Resistance in Pathogenic Bacteria

Muntaha R. Ibraheem 1*, Dhafar N. Al-Ugaili 2

Integrative Biomedical Research
Views: 2848 | Downloads: 32

Novel approach fights antibiotic resistance. Enhances DNA extraction efficiency. Eliminates resistance plasmids, aiding biotechnology. Highlights research needs for nanoparticle optimization and mechanism understanding.

Abstract | Full Text |PDF (596 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 11 March 2024

Control Mycotoxin Contamination in Tarasas Food Using A Lab Fermantion

Baraa Jameel Al-Assil 1,2*, Taghreed Abed Wahwah 3 

Integrative Biomedical Research
Views: 2329 | Downloads: 17

By utilizing LAB-mediated fermentation, this study demonstrated a natural and effective method for controlling mycotoxin contamination in traditional Tarasas food.

Abstract | Full Text |PDF (249 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 10 March 2024

Synthesis, Charecterization, Antibacterial and Cytotoxicity of Novel Metal Complexes Derived from Azomethine Ligand (Bis Azo-Schiff Base) In Vitro and In Silico

Hussein Abdulkadhim Hasan 1*, Saad M. Mahdi 1, Hanaa Addai Ali 2

Integrative Biomedical Research
Views: 2886 | Downloads: 61

This study demonstrated the synthesis of Schiff bases, like azo-Schiff metal complexes, showing therapeutic effects.

Abstract | Full Text |PDF (583 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 09 March 2024

A Rapid Continuous Flow Injection Analysis Method Development for Diphenhydramine Hydrochloride

Asma A. Gayed Al-Ani 1* , Nagham S. Turkey Al-Awadie 1*

Integrative Biomedical Research
Views: 2630 | Downloads: 33

Novel flow injection analysis improves Diphenhydramine HCL detection in pharmaceuticals with high sensitivity, speed, simplicity, and cost-effectiveness, enhancing industrial efficiency.

Abstract | Full Text |PDF (801 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 05 March 2024

Synthesis, characterization and Antibacterial Evaluation of Novel 1,3-Oxazepine Derivatives Using A Cycloaddition Approach

Farah M. Muhammad 1, Bushra A. Khairallah 1, K. A. Albadrany 1*

Integrative Biomedical Research
Views: 2931 | Downloads: 53

This study demonstrated a novel approach to the synthesis of oxazepine derivatives, key heterocyclic compounds with potential pharmacological applications.

Abstract | Full Text |PDF (650 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 05 March 2024

Synthesis, Characterization and Antibacterial Evaluation of Novel Thiazolidine Derivatives

Shaima H. Abdullah 1*, Mahmoud M. Salih 1, Khalid, A. Al-Badrany 1*

Integrative Biomedical Research
Views: 3406 | Downloads: 107

Thiazolidine derivatives, synthesized from heterocyclic compounds, exhibit diverse biological activities, including antibacterial effects against various bacterial strains, suggesting potential pharmaceutical applications.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 28 February 2024

Vitamin D In Modulating Liver And Kidney Functions Following Cadmium Exposure In Vivo

Ahmad Maher Ibrahim Al Sayeh 1, Walid Theib Mohammad 1*, Fernando Jesús Plaza del Pino 2

Integrative Biomedical Research
Views: 2639 | Downloads: 39

The research determined how vitamin D plays a vital part in relieving kidney and liver damage from cadmium, thus having important implications for treatment.

Abstract | Full Text |PDF (211 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 26 February 2024

Spectrophotometric Determination of Vitamin C Using Indirect Oxidation with a New Organic Dye

Asmaa Ahmed Mohammed Alrashidy 1, Omar Adnan Hashem 1, Kalid Abdul-Aziz ALBadrany 1

Integrative Biomedical Research
Views: 4205 | Downloads: 98

The research focuses on the indirect determination of vitamin C in various pharmaceutical formulations, as well as in natural fruit samples and commercially available juices. For the first time, a novel organic dye was utilized in the process, and it was found that the method was indeed effective for the quantification of vitamin C in these products.

Abstract | Full Text |PDF (448 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 17 February 2024

Efficacy of Paromomycin-Conjugated Nano Chitosan in Treating Entamoeba histolytica Infection in Mice

Hajar Falih Hishan Aldali 1*, Shatha Khudiar Abbas 1, Ahmed Naji Abd 1

Integrative Biomedical Research
Views: 2583 | Downloads: 36

Entamoeba histolytica causes widespread amebiasis. Chitosan-paromomycin nanoconjugates effectively treated infected mice, reducing liver enzyme levels, showing promising therapeutic potential.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 15 February 2024

Impact of Dapagliflozin on Atherosclerosis through Inflammation and Oxidative Pathways

Zainab Abdlkadhim Aboshnin 1*, Safa Azhar Razzaq 1, Zahraa Ibraheim Jawad Shubber 2

Integrative Biomedical Research
Views: 2328 | Downloads: 16

Atherosclerotic patients need therapies targeting inflammation and oxidation. This study supports Dapagliflozin's use for clinical benefits in atherosclerosis.

Abstract | Full Text |PDF (360 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 22 January 2024

Synthesis, Characterization and In Vitro Anti-cancer  Properties of Cationic Gemini Surfactants with Alkyl Chains in Human Breast Cancer

Anwar Shalan F. 1*, Samah Hussein Kadhim 1

Integrative Biomedical Research
Views: 2569 | Downloads: 18

Anti-cancer activity of Gemini surfactants in human breast cancer cells

Abstract | Full Text |PDF (1 MB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 21 January 2024

Renal and Hepatic Toxicity of Alpha-Cypermethrine Pesticide Used on Agricultural  Farmers Living Closed to Tigris river, Iraq

Sarhan Rashid Sarhan 1*,   Mohammed H.M. Merah 2

Integrative Biomedical Research
Views: 2665 | Downloads: 17

ALP, ALT and AST enzymes increased significantly when directly exposed to this pesticide as a result of its effect on kidney and liver functions.

Abstract | Full Text |PDF (436 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 21 January 2024

Therapeutic Effects of Esomeprazole, Curcumin, Chitosan, and Curcumin-Chitosan Mixture on Ethanol-Induced Gastric Ulcer in Female Rats

Jenan Mahdi Jawad Al-kawaz 1*, Fakhir Magtoof Al-Zubaidy 2**, Hussein Jassim Obaid Al -Harbi 1***

Integrative Biomedical Research
Views: 2749 | Downloads: 32

Evaluate the healing effects of esomeprazole, curcumin, chitosan, and a curcumin-chitosan mixture on gastric injuries induced by ethanol in rats.

Abstract | Full Text |PDF (737 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 19 January 2024

Optimizing Fast-Dissolving Tablets of Ketotifen: Impact of Sodium Bicarbonate and Citric Acid in Formulation and Evaluation

Rozhan Arif 1, Sharad Visht 1*, Ali Omar Yassen 1, Sana Sirwan Salih 1

Integrative Biomedical Research
Views: 2893 | Downloads: 44

Formulating ketotifen fast-dissolving tablets (FDT) tackled poor bioavailability challenges, emphasizing sodium bicarbonate's pivotal role for rapid tablet disintegration, highlighting FDT viability for asthmatic treatment.

Abstract | Full Text |PDF (556 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 17 January 2024

Innovative Piperidine-Catalyzation in Protecting Carbonyl Compounds with Implications for Angiogenesis and Inflammation

Mukhlif Mohsin Slaihim 1*, Luay Ali Dhahi 1, Abeer Hussein Ali 1

Integrative Biomedical Research
Views: 2373 | Downloads: 30

Introduced piperidine-catalyzed protection in aldehydes, guiding anti-cancer compound optimization.

Abstract | Full Text |PDF (804 KB) |Supplementary Material | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 05 December 2023

Gymnemagenin a Promising Drug Candidate for Management of Hyperglycemia: In-Vitro and In-Vivo Study

Javed Ahamad1, Saima Amin2, Kamran J Naquvi1, Showkat R Mir3*

Integrative Biomedical Research
Views: 3061 | Downloads: 36

Study of Gymnema sylvestre plant for the treatment and management of diabetes.

Abstract | Full Text |PDF (349 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 24 November 2023

Effect of Plumbago zeylanica on Analgesia and Arthritis

Subasini Uthirapathy1*

Integrative Biomedical Research
Views: 2563 | Downloads: 13

The inhibition activity of PZ on carrageenan-induced arthritis, humoral and cellular immunity, and pain and inflammation.

Abstract | Full Text |PDF (225 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 29 July 2023

Design, Synthesis, And Characterization Of New Schiff Bases For 3-Amino-1,2,4-Triazole-5-Thiolate Salt, Bearing Morpholine Ring And Biological Evaluation As Antibacterial Agents

Abeer Hussein Alia, and Mukhlif Mohsin Slaihimb*.

Integrative Biomedical Research
Views: 3150 | Downloads: 49

Antibacterial efficacy of new chemical compounds named benzaldehyde derivatives.

Abstract | Full Text |PDF (532 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 30 October 2021

Cannabis Sativa: A Remedy for Convulsion by Inhibition of GABAA Receptor and Significantly Delayed Onset of Seizure Latency and Death - An Experimental Validation and Molecular Docking

Ben Enoluomen Ehigiator1, SamuelKelechi Mobisson2, Iheanyichukwu Wopara3*, Chinonye Cynthia Chibuife1, Uwaezuoke Chukwuekele Awarajih3, Harrison Ogheneochuko Eruotor3

Integrative Biomedical Research
Views: 2672 | Downloads: 33

Abstract | Full Text |PDF (521 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 12 September 2020

Dose Dependent Synergism from Combination of Platinum Drugs with Curcumin against Colorectal Cancer Cell Lines

Hana Bali1, Jun Qing Yu1, Philip Beale2, and Fazlul Huq3

Integrative Biomedical Research
Views: 2886 | Downloads: 12

Ox in combination Cur demonstrated very high synergism against HT-29 and Caco-2 cell lines.

Abstract | Full Text |PDF (1002 KB) | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 11 May 2019

Anti-GBM potential of Rosmarinic acid and its synthetic derivatives via targeting IL17A mediated angiogenesis pathway

Md Shamsuddin Sultan Khan A,C,E, Mohammad Adnan Iqbal B, Muhammad Asif A, Tabinda Azam B, Majed Al-Mansoub A, Rosenani S. M. A. Haque B, Mohammed Khadeer Ahamed Basheer C, Aman Shah Abdul Majid D, Amin Malik Shah Abdul Majid A,C,E*

Integrative Biomedical Research
Views: 3837 | Downloads: 64

Metal salts and base rosmarinates demonstrated potent anti-GBM efficacy as IL17A inhibitor with minimal toxicity.   

Abstract | Full Text |PDF (1 MB) |Supplementary Material | Open Access Article


Research Article | Pharmacology & Drug Discovery
Published online 04 February 2019

Ethosomal formulation composed of standardized Orthosiphon stamineus extract and sophorolipid inhibits angiogenesis of melanoma in vivo

Mansoureh Nazari Vishkaei a, Mohamed Khadeer Ahamed Basheer c, Amin Malik Shah Abdul Majid a,b

Integrative Biomedical Research
Views: 2970 | Downloads: 40

SLOS vesicles can be considered for effective dermal therapeutic agent for the treatment of skin cancer.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Reviews

Pharmacology & Drug Discovery

Reviews | Pharmacology & Drug Discovery
Published online 09 September 2026

From Days to Hours: Artificial Intelligence in Antimicrobial Resistance Diagnostics and Drug Discovery, and Why No Tool Has Yet Reached the Clinic

Nahid Amin1*, Papiya Sultana Sharker Sharna1

Integrative Biomedical Research
Views: 350 | Downloads: 2

AI compresses AMR diagnosis and discovery timelines dramatically, yet no tool has reached regulatory clearance — validation and trust, not algorithms, remain the bottleneck.

Abstract | Full Text |PDF (587 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 11 March 2026 Manuscript-In-Press

Integrating Genomics, Transcriptomics, and Organoid-Based Drug Testing for Precision Cancer Care

Yoghinni Manogaran 1*, Ahmed Ahmed Al-Akwaa 2

Integrative Biomedical Research
Views: 222 | Downloads: 0

Integrating transcriptomic, epigenetic, and functional organoid data with genomics may finally close oncology’s persistent gap between diagnosis and matched treatment.

Abstract | Full Text | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 16 July 2025

Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration

Mohammad Lutfor Rahman1*

Integrative Biomedical Research
Views: 2334 | Downloads: 31

Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.

Abstract | Full Text |PDF (729 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 12 May 2025

A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review

Nazmun Nahar 1, 2*

Integrative Biomedical Research
Views: 2707 | Downloads: 28

The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.

Abstract | Full Text |PDF (296 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 02 May 2025

Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives

Mohammad Lutfor Rahman1*, Md Al Mamun2, Ahad Ahamed3, Mohosin Kabir4, Faranak Nadarkhani Dinehkaboudi4, Marziyeh Zangeneh4, Md. Nezab Uddin5, AHM Quamruzzaman6

Integrative Biomedical Research
Views: 4407 | Downloads: 88

This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.

Abstract | Full Text |PDF (565 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 07 January 2025

PEGylated Liposomal Teriflunomide: A Novel Approach of Targeted Breast Cancer Treatment to Advance Efficacy and Minimize Adverse Effects

Dipanjan Koley1, Vaibhav Walia2, Mohammed. Aslam3, Manvi Singh4*

Integrative Biomedical Research
Views: 2104 | Downloads: 16

Developing pegylated liposomal teriflunomide may enhance breast cancer treatment efficacy, reduce side effects, and improve patient outcomes.

Abstract | Full Text |PDF (426 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 15 December 2024

Investigating the Impact of Tablet Coatings on Gastrointestinal Tract Residence Time and Drug Bioavailability: A Comparative Study of Different Coating Materials

Mohosin Kabir 1*, Nadimbhai Salimbhai Vahora 1

Integrative Biomedical Research
Views: 2639 | Downloads: 16

This review discusses the importance of tailored tablet coatings to optimize drug release, stability, bioavailability, and therapeutic efficacy.

Abstract | Full Text |PDF (414 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 08 December 2024 5837.jpg?638721948664764304

The Role of Quality Assurance in Accelerating Pharmaceutical Research and Development: Strategies for Ensuring Regulatory Compliance and Product Integrity

Mohosin Kabir 1*, Md. Refayet Hossen Rana 2, Arnab Debnath 3

Integrative Biomedical Research
Views: 4752 | Downloads: 331

This study highlights the role of Quality Assurance in ensuring product integrity, patient safety, and driving pharmaceutical innovation.

Abstract | Full Text |PDF (334 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 01 November 2024 5783.jpg?638703242785827257

Disrupting Bacterial Biofilms to Combat Dental Diseases Using Nanotechnology in Oral Healthcare

Hunny Dabas1, Faraat Ali2, Fairy3, Khushi Quadri1, Manshi Dangi1, Parween Jamil4, Mohammed Aslam5, Manvi Singh1*

Integrative Biomedical Research
Views: 3377 | Downloads: 34

This review discusses the use of nanoparticles as innovative solutions for disrupting bacterial oral biofilms, enhancing antimicrobial efficacy, and revolutionizing oral healthcare with minimal resistance.

Abstract | Full Text |PDF (673 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 18 October 2024 5741.jpg?638744276580671552

Advancements in Nanotechnology-Based Paclitaxel Delivery Systems: Systematic Review on Overcoming Solubility, Toxicity, and Drug Resistance Challenges in Cancer Therapy

Balisa Mosisa Ejeta1*, Malay K Das1, Sanjoy Das1

Integrative Biomedical Research
Views: 3084 | Downloads: 39

This study showed advanced nanotechnology-based paclitaxel delivery systems, offering enhanced cancer targeting, reduced side effects, and potential solutions to drug resistance.

Abstract | Full Text |PDF (174 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 17 October 2024

Advancements in Quinazoline Derivatives as Targeted Anticancer Agents: A Review on its Synthesis, Mechanisms, and Therapeutic Potential

Mohd. Javed Naim 1*

Integrative Biomedical Research
Views: 3606 | Downloads: 42

This review highlights the therapeutic potential of quinazoline derivatives in cancer treatment, focusing on their ability to target critical tyrosine kinases and offering insights into their development as effective anticancer agents.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 08 October 2024

Advances in SGLT2 Inhibitors for Type 2 Diabetes Management

Mohd. Javed Naim 1*

Integrative Biomedical Research
Views: 3431 | Downloads: 36

This review highlights novel SGLT2 inhibitors, emphasizing their potential in enhancing therapeutic options for type 2 diabetes management.

Abstract | Full Text |PDF (933 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 02 October 2024

Emerging Lipid-Lowering Therapies: A Comprehensive Review of Novel Agents Targeting Hyperlipidemia

Subasini Uthirapathy 1*

Integrative Biomedical Research
Views: 4089 | Downloads: 42

This review provides innovative therapies targeting lipid metabolism, offering personalized options to improve outcomes in hyperlipidemia management.

Abstract | Full Text |PDF (419 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 12 September 2024 5696.jpg?638744270055220446

Transformative Role of Artificial Intelligence in the Pharmaceutical Sector

Balisa Mosisa Ejeta*1, Malay K Das2*, Sanjoy Das3, Fetene Fufa Bekere4, Dubom Tayeng5

Integrative Biomedical Research
Views: 2934 | Downloads: 50

This review highlights AI's potential to revolutionize drug discovery, development, and regulatory processes, improving patient outcomes and healthcare efficiency.

Abstract | Full Text |PDF (182 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 09 August 2024

Artificial Intelligence in Drug Development and Delivery: Opportunities, Challenges, and Future Directions

Rabi Sankar Mondal1*, Lamia Akter2, Md Nazmul Alam Bhuiyan1

Integrative Biomedical Research
Views: 2172 | Downloads: 14

AI is revolutionizing drug development by accelerating discoveries and creating more personalized treatments, thereby making healthcare more efficient for everyone.

Abstract | Full Text |PDF (335 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 09 August 2024

Recent Advances in Paclitaxel Drug Delivery: Challenges, Innovations, and Future Directions

Balisa Mosisa Ejeta 1*, Malay K Das 1*, Sanjoy Das 1

Integrative Biomedical Research
Views: 3812 | Downloads: 44

This review addresses advancements in paclitaxel drug delivery, emphasizing innovative methods to enhance efficacy and combat resistance.

Abstract | Full Text |PDF (700 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 27 July 2024

Unlocking the Potential of Pig Models in Atherosclerosis Research: Insights, Applications, and Future Directions

Anastasia V. Poznyak 1*, Alexey V. Churov 2,3, Irina Alexandrovna Starodubtseva 4, Natalia V. Elizova 2, Tatiana Ivanovna Kovyanova 1,3, Vasily N. Sukhorukov 3, and Alexander N. Orekhov 3

Integrative Biomedical Research
Views: 2899 | Downloads: 36

This review describes the understanding of atherosclerosis through animal models aids in revealing disease mechanisms, testing treatments, and improving therapeutic strategies for humans.

Abstract | Full Text |PDF (968 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 01 April 2024

A Comprehensive Review of the Pharmacology of Statins and its Clinical Implications

Athiban Inbarajan 1*, Giri GVV 2, Anusha D 3, Alan Mathew Punnoose 4, Jasline David J 5, Mubeena S 6

Integrative Biomedical Research
Views: 2550 | Downloads: 38

The study aims to provide a detailed understanding of statins, their pharmacodynamics, and the various types involved as beneficial agents in the treatment of bone resorption and hypercholesterolemia.

Abstract | Full Text |PDF (355 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 24 February 2024

Advancements of Polymer-Based Transdermal Drug Delivery Systems in Drug Bioavailability and Patient Compliance in United States

Hunny Dabas 1, Deepika Singh 1, Faraat Ali 2, Dipanjan Koley 1, Mohammed. Aslam 3, Esra Tariq Anwer Bayrakdar 3, Manvi Singh 1*

Integrative Biomedical Research
Views: 3483 | Downloads: 60

This review comprehensively discusses the transdermal drug delivery systems (TDDS) in the area of drug administration, for non-invasive, precise, and efficient delivery, overcoming oral limitations.

Abstract | Full Text |PDF (536 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 08 February 2024

Repurposing Drugs for Overcoming Therapy Resistance in Colon Cancer – A Review

Mahdi Darvishi 1, Amir Mohammad Chekeni 2, Mohammad Fazelhosseini 1, Zeenat Iqbal 3*, Mohd Aamir Mirza 3*, Mohammed Aslam 4, Esra Tariq Anwer Bayrakdar 4

Integrative Biomedical Research
Views: 5417 | Downloads: 50

Oncology research seeks new therapies for aggressive CRC, utilizing repurposed drugs for accelerated and safer treatment approaches.

Abstract | Full Text |PDF (842 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 23 January 2024

A Review of Modeling Checkpoint Blockade Therapy and Therapeutic Strategies in Integrative Pharmacological Approach for Metastatic Breast Cancer

Prachi Gurudiwan 1*, Ragini Patel 1, Urvashi Jain 1

Integrative Biomedical Research
Views: 1972 | Downloads: 8

Quantitative Systems Pharmacology models immune processes in breast cancer, aiding personalized treatment by identifying biomarkers, resistance mechanisms, and therapeutic options

Abstract | Full Text |PDF (1 MB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 23 January 2024

A Systematic Review of Advanced Approaches in Wound Healing: Simvastatin Polymeric Nanoparticles and Postbiotics Innovation

Chandrapratap Dhimar 1*, Krishna Sahu 1, Moniza Nurez Khan 1

Integrative Biomedical Research
Views: 2368 | Downloads: 27

Utilizing innovative postbiotics and Simvastatin Polymeric Nanoparticles, wound research accelerates healing, promising improved treatment with minimal inflammation.

Abstract | Full Text |PDF (652 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 22 January 2024

Machine Learning-Based Enhanced Drug Delivery System and Its Applications – A Systematic Review

Abhijeet  Madhukar Haval 1*, Kumar Shwetabh 1, Sushree Sasmita Dash 1

Integrative Biomedical Research
Views: 2740 | Downloads: 29

Machine Learning (ML) transforms drug development, predicting drug properties, targets, interactions, and facilitating efficient exploration for researchers and pharmaceutical companies.

Abstract | Full Text |PDF (528 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 18 January 2024

Curcumin Nanocarriers with a Focus on Cellular Uptake Studies – An Innovative Cancer Therapy

Kalpita Bhatta 1, Pratikshya Mohanty 1, Itishree Jogamaya Das 2, Himansu Bhusan Samal *3

Integrative Biomedical Research
Views: 3109 | Downloads: 24

Using curcumin nanocarriers could provide several benefits in combating cancers

Abstract | Full Text |PDF (648 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 08 January 2024

A Review of Dipeptidyl Peptidase-4 (DPP-4) and its potential synthetic derivatives in the management of Diabetes Mellitus

Mohd. Javed Naim 1

Integrative Biomedical Research
Views: 4464 | Downloads: 104

To establish potential DPP-4 inhibitors. 

Abstract | Full Text |PDF (756 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 17 December 2023

Epidermal Growth Factor Receptor and Double-Imprinted Nanoparticles for Targeted Cancer Drug Delivery - A Review

Lakhan Lal Kashyap 1, Harish Jaiswal 2

Integrative Biomedical Research
Views: 2121 | Downloads: 6

A targeted drug delivery approach, using double-imprinted nanoparticles and EGFR-SVM, to enhance anticancer drug effectiveness selectively in tumor cells.

Abstract | Full Text |PDF (446 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 12 December 2023

Hydrophobin-Coated Noisomes as Drug Carriers in Lung Cancer Cells - A Review

Srishti Namdeo 1, Chandrapratap Dhimar 2

Integrative Biomedical Research
Views: 1929 | Downloads: 5

Targeted nanoparticle delivery to Lung Cancer Cells, using hydrophobin-coated niosomes, addressing multidrug resistance, and enhancing treatment efficacy.

Abstract | Full Text |PDF (880 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 08 December 2023

Analyzing The Risks, Benefits, and Therapeutic Potential of Cannabis And Cannabinoids in Tumor Therapy - A Review

Poorti Sharma 1*, Lukeshwari Sahu 1

Integrative Biomedical Research
Views: 2078 | Downloads: 5

Study explores Cannabis use by metastatic tumor patients, analyzing active components, addressing gaps in research, and promoting informed medical guidance.

Abstract | Full Text |PDF (769 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 06 December 2023

Evaluation of Cardiac Reserve Using Echocardiography for The Detection of Mild Cardiac Dysfunction in Mice - A Review

Sanjay Kumar Mire 1, Deepak Kumar Sahu 2

Integrative Biomedical Research
Views: 2135 | Downloads: 8

Echocardiography-based strain imaging offers early detection of cardiac abnormalities, treatment, and research strategy. 

Abstract | Full Text |PDF (951 KB) | Open Access Article


Reviews | Pharmacology & Drug Discovery
Published online 04 December 2023

Drug Repositioning and Response Detection Based on Randomized Control Trials for Cancer Treatment - A Review

Aman Chandrakar 1, Chetan Kumar Sonkar 2

Integrative Biomedical Research
Views: 2378 | Downloads: 24

The cancer treatment will be accelerated through drug repositioning.

Abstract | Full Text |PDF (1 MB) | Open Access Article


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