Integrative Biomedical Research
Latest Issue - Volume 10 Number 2 2026
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles in following topics:
- Molecular & Cellular Biomedicine
- Pharmacology & Drug Discovery
- Clinical & Translational Medic
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Integrative Biomedical Research
Table of Contents
Case Study
Natural Products & Pharmacognosy
Aman Shah Abdul MajidA*, Elham FarsiB, Natesan VijayalakshmiC, Syarifah Aisya Syed AmranD, Mahibub Mahadmadsa KanakalE, Zarina Thasneem ZainudeenF*
Labisia pumila extracts based products will require robust studies to be conducted utilizing larger patient numbers and over extended periods of time to rule out any potential toxic effects.
Abstract | Full Text |PDF (769 KB) | Open Access Article
Research Article
Natural Products & Pharmacognosy
Shahrina Shah Jahan1, Wan Amir Nizam Wan Ahmad 2, Rafidah Husen1
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
Abstract | Full Text |PDF (407 KB) | Open Access Article
Damilola A. Omoboyowa1*, Elijah A. Agboola 1, Damilola S. Bodun 1, Simbo T. Akinsulure 1, Samia Belahcene 2, Dhurgham Al-Fahad 3
Curculigo pilosa extracts exhibit strong antioxidant properties, mitigating oxidative stress in Drosophila melanogaster, highlighting potential therapeutic applications.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
Sakina Ruhi1, Nur Alyssya Binti Yusoff 2*, Sohayla M. Attalla3, Jiyauddin Khan3, Norshafarina Shari Kamaruddin3, Indang Ariati2, Husni Ahmed Al-Gosha1, Subramanian Rammohan1, Ayesha Syed 1, Rajesh Thangarajan1
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
Abstract | Full Text |PDF (220 KB) | Open Access Article
Naima Layachi 1, 2*, Amel Berrezeg 3, 4
Ethyl acetate extract of Laurus nobilis leaves showed potent antioxidant and anti-inflammatory activities, highlighting its therapeutic and pharmacological potential.Pages: 1-8
Abstract | Full Text |PDF (331 KB) | Open Access Article
Md. Shakil Ahmed1, Saima Jahan Oishe1, Farhana Rahman1, Rabeya Basri1, Mahbuba Haque1, Mirza Nipa Monalisa1, Nishat Rayhana1, Shamima Ahsan1, Shangita Dev1, Md. Atiqur Rahman1*
This study documents plant diversity, cultural significance, and regional ethnomedicinal similarities, promoting sustainable traditional knowledge preservation and pharmacological research.
Abstract | Full Text |PDF (850 KB) |Supplementary Material | Open Access Article
Rahmat A Hi Wahid1*, Okti Purwaningsih2
Eco-enzyme fertilizer might enhance secondary metabolites in young turmeric rhizomes, offering insights into sustainable agriculture and medicinal compound optimization.
Abstract | Full Text |PDF (284 KB) | Open Access Article
Rizwan Rashid Bazmi1, Muhammad Asif2**, Hafiza Sidra Yaseen3, Pharkphoom Panichayupakaranant1,4*
The present study has an impact on overcoming the inflammation problem, which can lead to various types of chronic inflammatory diseases, using the artocarpin & artocarpin-rich Artocarpus heterophyllus extract. The primary significance of this research is the achievement of preparation of a natural anti-inflammatory and analgesic agent using a green chemistry, which contributes to combat inflammation and analgesia. Furthermore, this method is practically used for industrial commercialization.
Abstract | Full Text |PDF (508 KB) | Open Access Article
Antioxidant Effects of Ocimum tenuiflorum on Catalase and Glutathione Peroxidase In Vivo
Pande Ayu Naya Kasih Permatananda1,2*, I Wayan Sumardika2, I Wayan Putu Sutirta Yasa2, Made Ratna Saraswati2, I Gde Suranaya Pandit3, Sri Masyeni1
This study demonstrated Ocimum tenuiflorum’s antioxidant potential, enhancing catalase and glutathione peroxidase activities in diabetic mice to mitigate oxidative stress.
Abstract | Full Text |PDF (184 KB) | Open Access Article
Dewi Yudiana Shinta1, Widyastuti Widyastuti2, Def Primal3*, Herix Sonata MS4, Saryono Saryono5
This study determines the potential wound healing therapies of endophytic fungal extracts with enhanced collagen formation and tissue regeneration in Candida albicans-infected wounds
Abstract | Full Text |PDF (859 KB) | Open Access Article
Raafat M. Alaatabi 1, Falah Hassan Shari 2, Mrs.Poulami Sen 3, Gunawan Widjaja 4
This study showed the potential of plant-based creams and gels as stable, effective, topical anti-inflammatory agents, reducing cytokine-induced inflammation.
Abstract | Full Text |PDF (215 KB) | Open Access Article
Hanan M. El-Tantawy 1*
This study determined the potential therapeutic benefits of E. r. ssp. schimperi in managing insulin resistance and oxidative stress.
Abstract | Full Text |PDF (804 KB) | Open Access Article
Danang Raharjo 1, Haryoto 1*, Tanti Azizah Sujono 1, Heng Yen Khong 2, 3 *
This study determined the antidiabetic potential of Nypa fruticans fronds by inhibiting carbohydrate-degrading enzymes and reducing glucose absorption.
Abstract | Full Text |PDF (386 KB) | Open Access Article
Nutmeg (Myristica fragrans) Extracts Accelerate Oral Mucosal Wound Healing In Vivo
Dewi Rosmalia 1, Minarni 1, Mhd Riza Marjoni 2*
This study demonstrates Nutmeg’s potential in enhancing oral mucosal wound healing, providing safer, effective alternatives for dental care.
Abstract | Full Text |PDF (187 KB) | Open Access Article
Javed Ahamad 1*
This study determined the cardamom essential oil's bioactive components and its promising anticancer effects against TNBC, glioma and kidney cells.
Abstract | Full Text |PDF (429 KB) | Open Access Article
Shatadhauta Ghrita and Panchavalkala Prevent Wound Healing In Vivo
Tripti Dewangan 1*, Kishor Kumar Sahu 1
This study determined the potential of ancient Ayurvedic formulations for modern wound care, promoting effective healing while reducing treatment costs.
Abstract | Full Text |PDF (264 KB) | Open Access Article
Netty Ino Ischak 1*, Loso Judijanto 2, Eddyman W Ferial 3
This study explored nutrient effects of Anadara granosa and Spirulina platensis on improving sperm quality in preclinical Mus musculus trials.
Abstract | Full Text |PDF (346 KB) | Open Access Article
Antifungal Efficacy of Garlic and Olive Oil Against Candida albicans and Penicillium palitans
Amani Alhejely 1*
The study demonstrates the potential of garlic and olive oil as natural antifungal agents in managing fungal infections.
Abstract | Full Text |PDF (169 KB) | Open Access Article
Lanctos 75™ is A Novel Retino-Protective and Neovascular Inhibitor for Diabetic Retinopathy
Fouad Saleih Resq Al-Suede 1, Muhammad Asyraf Abduraman 1, Indumathi Ashok 2, Gnanasekaran Ashok 3, Khadeer Ahamed basheer 1, Amin Malik Shah Abdul Majid 4,5*, Aman Shah Abdul Majid 2*
This study evaluates Lanctos 75™ as a potential therapeutic agent for diabetic retinopathy, targeting angiogenesis, oxidative stress, and inflammation.
Abstract | Full Text |PDF (727 KB) | Open Access Article
Antifungal Properties of Dracaena cinnabari Resin Extracts Against Candida albicans
Rola Ali-Saeed1*, Aied M. Alabsi2, Siti Sufiah Shaherah binti Zainudin1, Nur Nadhirah binti Harun1, Lee Min Quan1, Siddig Ibrahim abdelwahab3, Antony V Samrot 4, Vetriselvan Subramaniyan5, Ismail, Muhamad Fareez6
This study determined Dracaena cinnabari's resin as a promising natural antifungal agent against Candida albicans, particularly in oral candidiasis.
Abstract | Full Text |PDF (369 KB) | Open Access Article
Raimova Guli Madmurodovna1, Nasirov Kabil Erkinovich1, Khodjiyev Sirojiddin Salimovich.1,Ortikov Mukhamadkodir Musajonovich1, Maxmudov Rustam Rasuljonovich2, Toshtemirova Muazzam Akmaljonovna3, Isagalieva Sadafhon Mukhammadaminovna3 ,Usmanova Muhayyokhan Sobirjonovna4
This study demonstrated the potential of specific polyphenolic compounds in regulating hemostasis and biochemical imbalances in type 2 diabetes mellitus.
Abstract | Full Text |PDF (384 KB) | Open Access Article
Natural Diabetes Treatment with Litchi Seeds Extract In Vivo
Mustakin Ahmed Shohel 1, Abul Kashem Tang 2, Inampudi Sailaja 3, T M Tawabul Islam 1, Md. Humayan Kabir 2, Nirmal Chandra Mahat 2, Ivvala Anand Shaker 4*
This study demonstrated the therapeutic potential of litchi seeds for diabetes as safer, effective alternatives to synthetic drugs.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel 1, Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1
The study showed fenugreek’s potential to improve male fertility by enhancing sperm characteristics in hypothyroid conditions.
Abstract | Full Text |PDF (225 KB) | Open Access Article
Raad A Kaskoos 1, Javed Ahamad 2 *
Black cumin oil's rich chemical composition and significant anticancer activity against osteosarcoma cells support its traditional medicinal uses.
Abstract | Full Text |PDF (321 KB) | Open Access Article
Mohd Hasan Mujahid 1, Tarun Kumar Upadhyay 1*, Vijay Jagdish Upadhye 2*, Prasanna Sriram Mathad 3
This study determined the therapeutic potential of Aqueous Zingiber officinale rhizome extract (AZOME) in combating oxidative stress, microbial infections, diabetes, and glycation-related complications.
Abstract | Full Text |PDF (2 MB) |Supplementary Material | Open Access Article
B Jyotirmayee 1, Subhashree Tripathy 1, Himansu Bhusan Samal 2*, Gyanranjan Mahalik 1*
Organic fertilizers boost growth, yield, and bacterial diversity in black turmeric, supporting medicinal plant preservation and drug development.
Abstract | Full Text |PDF (895 KB) | Open Access Article
Avocado (Persea americana Mill.) Leaf Extract for Diabetic Ulcer Treatment In Vivo
Lita Retta 1, Endy Juli Anto 4,5, Jekson Martiar Siahaan 2,3*, Syafruddin Ilyas 6, Menang Bastanta 7,8
Avocado leaf extract demonstrated potential in reducing blood sugar, enhancing wound healing, and mitigating inflammation, offering a novel diabetic ulcer treatment.
Abstract | Full Text |PDF (497 KB) | Open Access Article
Ameliorative Effect of Red Grape Leaf Extract on Insulin Resistance: In Vivo And In Silico Studies
Naglaa M. Hamdy 1, 2*, Hanan M. El-Tantawy 1
Red grape leaf extract contains polyphenols, particularly resveratrol, which can potentially control insulin resistance and non-alcoholic fatty liver disease.
Abstract | Full Text |PDF (690 KB) | Open Access Article
Anti-inflammatory and Antioxidant Activity of Rosemary Essential Oil
Duaa Y. Khalil 1, Omar M. Hassan 1*
This study proved that Rosemary essential oils have Anti-inflammatory and Antioxidant Properties.
Abstract | Full Text |PDF (368 KB) | Open Access Article
Quercus infectoria Bark Extract Shows Antibacterial Activity Against Staphylococcus Species
Zainab Ahmed Aziz 1*, Siham Jasim Al Kaabi 1
This study determined the effect of Quercus infectoria bark as antibiotic and its resistance in bacterial infections.
Abstract | Full Text |PDF (496 KB) | Open Access Article
Antibacterial Activity of Sidr (Ziziphus spina-christi) Plant Extracts against Urinary Pathogens
Amal Naif Alshammari 1*
Sidr plant extracts showed promising antibacterial activity against urinary pathogens as potential alternative of UTI treatments.
Abstract | Full Text |PDF (211 KB) | Open Access Article
Afnan Esam Adnan 1*, Wisam Malik Dawood 1*
Cruciferous Plant-derived compounds showed diverse medicinal properties, combating antibiotic resistance, providing therapeutic alternatives, and inhibiting biofilm formation in pathogenic bacteria.
Abstract | Full Text |PDF (248 KB) | Open Access Article
Abdulilah Hanan Abdul Qader 1, Hind Hamid Hasan 2, Ashwaq Talib Hameed 3*, Hanan Y. Houmady 4, Rafraf abdul aziz abdul qader 5
The study provides valuable insights into heavy metal absorption by specific Iraqi wild plants, offering opportunities for phytoremediation and medicinal applications.
Abstract | Full Text |PDF (444 KB) | Open Access Article
Treatment of Hypothyroidism with Flavonoid Rich Extract of Fucus vesiculosus L Algae in Adult Rats
Somaya M. Eshtiwi 1*
Flavonoid extract from Fucus vesiculosus algae showed a thyroid activity modulator for the treatment of thyroid disorders.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Abdulah Y. Al-Mahdi 1, Alabed Ali A. Alabed 2, Hana W. Jun Chen1, Mohammed Faez Baobaid 1, Sakina Ruhi 1, Jegathambigai Rameshwar Naidu 1, Mukti Nor Ashikeen 1, Husni Ahmed Abdullah Al-Goshae 1, Imad I. Al-Sultan1, Mahfoud A.M. Abdulghani 1, Abusif Sonousi 3, Elan Selvi Anandan 4, Belqes Hamood Serag 5
This research showed that essential oils derived from medicinal plants are antibiotic-resistant by exhibiting strong antibacterial activity against multidrug-resistant pathogens, suggesting potential alternative options against antibiotic resistance.
Abstract | Full Text |PDF (480 KB) | Open Access Article
In vitro Cytotoxicity of Activated Carbon from Musa Acuminate Fruit Peel Against HepG-2 Cells
Shanmugasundaram M 1, Prasath S 2, Geetha N B 2, Manikandan S 2
Activated carbon from Musa Acuminate exhibits potent inhibitory effects on HepG-2 cells via ROS-mediated MTD pathway, suggesting therapeutic potential against cancer.
Abstract | Full Text |PDF (519 KB) | Open Access Article
Cumin Extract Alters The Histology of Kidney and Duodenum in Adult Rabbit
Hussein B. Mahmood 1*, Naseer A. Al-Arubaye 1, Walaa F. Obead 1
This study showed the histological alterations of the kidney and duodenum due to excessive use of cumin.
Abstract | Full Text |PDF (480 KB) | Open Access Article
Geetha N B 1, Priya R 1, Weslin D 1, Ashmi Christus A T 2
The study of anti-cancer properties of Actinidia deliciosa methanol extract in Colorectal cancer as effective treatments.
Abstract | Full Text |PDF (330 KB) | Open Access Article
Geetha N B 1*, Chintala Venkatesh 1, Suresh M 1, Manikandan S 2
Allium ascalonicum might be a safer, more effective alternative to toxic chemotherapy for combating cancer with targeted potency.
Abstract | Full Text |PDF (266 KB) | Open Access Article
Kartheeswari 1, Archana C 1, Anupreyaa K 1, Saranya M 2
Assessment of A. deliciosa extracts' anticancer potential on MCF-7 cells offers insights for natural cancer medication development
Abstract | Full Text |PDF (411 KB) | Open Access Article
A Double-blind, Randomized Clinical Trial Study of Plantago major l. Syrup on Menorrhagia
Sajedeh Ghasempour 1, Mohsen Naseri 2, Fatemeh Alijaniha 2, Yasin Karimi 3, Anoushirvan Kazemnejad 4, Shahrzad Hadavand 5 , Seyedeh Fatemeh Jafari 2, 6
The study highlights Plantago major's potential to reduce menorrhagia severity and duration, offering a promising complementary treatment with minimal side effects.
Abstract | Full Text |PDF (326 KB) | Open Access Article
Betty Fitriyasti 1*, Siska Ferilda 2, Widia Sari 3, Muhammad Rizki Saputra 4, Heng Yen Khong 5*
Rhinacanthus nasutus extract inhibits the growth of Staphylococcus aureus and could serve as an alternative in treating infections caused by S. aureus.
Abstract | Full Text |PDF (396 KB) | Open Access Article
Anti-Cancer Study of Carvacrol in Hypoxic-Induced Colorectal Cancer Cell
Aumaima Tariq Abed 1,2* , Ahmed MH AlMudhafar 1 , and Najah R Hadi 1
Effect of carvacrol on proliferation and migration of hypoxic SW480 cancer cells
Abstract | Full Text |PDF (586 KB) | Open Access Article
Advancing Therapeutic Efficacy of Star Anise Oil with (Illicium verum) Nano-Emulsion Formulation
Sharad Visht 1, Sana Sirwan Salih 1, Belan Azad Ibrahim 1, Daniah Issa Ismael 1, Serwa Falah Abdalwaheed 1, Omji Porwal 1
Star anise oil-based nano-emulsions' extraction, purification, and formulation processes to improve therapeutic efficacy of drug substances
Abstract | Full Text |PDF (1 MB) | Open Access Article
Mostafa Alamholo 1
Identification of active compounds in medicinal plants to control resistant bacteria
Abstract | Full Text |PDF (434 KB) | Open Access Article
Javed Ahamad 1*
The study of Clove essential oil as an antioxidant drug.
Abstract | Full Text |PDF (470 KB) | Open Access Article
Pomegranate Juice Attenuates Anti-ulcer in Indomethacin-induced Peptic Ulcer
Ali Omar Yaseen 1, Payam Jamal Muhamed 1, Hacer Haltas 1 , Subasini Uthirapathy 1*
Study on using pomegranate juice supplements to treat ulcers caused by pain medications.
Abstract | Full Text |PDF (489 KB) | Open Access Article
Sawsan S. Al-Rawi1*, Ahmad Hamdy Ibrahim2, Marthad A. Hamde3, Dinesh Babu4, Mansoureh Nazari5, Mohd Omar Ab Kadir6, Aman Shah Abdul Majid7, Amin Malik Shah8
Abstract | Full Text |PDF (2 MB) | Open Access Article
Haryoto1*, Alysa Vivi Arnida1, Peni Indrayudha1, Cita Hanif Muflihah1, Khong Heng Yen2
Mareme and Sala leaves mix may be a strong blood sugar blocker, but it contains useful chemicals for potential medical research.
Abstract | Full Text |PDF (318 KB) | Open Access Article
Nurr Maria Ulfa Seruji1, Vivien Jong Yi Mian1*, Nor Hisam Zamakshari2, Thiruventhan Karunakaran3, Lee Feng Koo4, Wong Tze Jin4, Chan Thye Huat5
Study of potential Therapeutic activity of Calophyllum herb.
Abstract | Full Text |PDF (444 KB) | Open Access Article
Nur Royhaila Mohamad *1, Farrah Payyadhah Borhan 2, Mohd Shahrizi Razali 3, Roswanira Abdul Wahab 4
Utilize statistical methods to determine which different variables impact the response to the extraction of roselle.
Abstract | Full Text |PDF (514 KB) | Open Access Article
Investigation Of Anti-Tumour Activity Of Orthosiphon Stamineus On Human Oral Squamous Cell Carcinoma
Shah kamal Bin Jamal Dina, Fouad Saleih Resq Al-Suedeb,c*,Farahnaz Aminid, Aman Shah Abdul Majide, JackTan Chun Keatd, Amin Malik Shah Abdul Majidf .
The potential of Nuvastatic in the treatment of oral squamous cell carcinoma.
Abstract | Full Text |PDF (602 KB) | Open Access Article
Phytochemical, Antimicrobial, and Wound-Healing Evaluation of Alpinia nigra, Bacopa monnieri, Calotropis gigantea, and Cynodon dactylon In Vivo
Nazia Mahmud Badhon 1*
This study validates Bangladeshi medicinal plants as effective antimicrobial and wound-healing agents, bridging traditional practices with modern pharmacological innovations.
Prakash Dabadi1, Fouad Saleih Resq AL-Suede2,3*, Chandrashekhar VM4*, Mallappa Shalavadi 4 , Ashok Gnanasekaran5
Development of therapeutics for the treatment of hepatotoxicity and oxidative stress induced by ATDs
Abstract | Full Text |PDF (589 KB) | Open Access Article
Ashwaq Hamid Salem Yehyaa,*, Majed Ahmed Al-Mansoubb, Fouad Saleih Resq Al-Suedea, Siti Balkees Binti STN Hameed Sultana, Muhammad Asyraf Abduramana, Noor Amanina Azmic, Mufda jameel abedalhadi alrawashdehd, Seyedeh Fatemeh Jafarie, Amin Malik Shah Abdul Majida,f
Abstract | Full Text |PDF (1015 KB) | Open Access Article
Rizwan Rashid Bazmi1, Muhammad Asif2**, Hafiza Sidra Yaseen3, Pharkphoom Panichayupakaranant1,4*
The present study has an impact on overcoming the inflammation problem, which can lead to various types of chronic inflammatory diseases, using the artocarpin & artocarpin-rich Artocarpus heterophyllus extract. The primary significance of this research is the achievement of preparation of a natural anti-inflammatory and analgesic agent using a green chemistry, which contributes to combat inflammation and analgesia. Furthermore, this method is practically used for industrial commercialization.
Abstract | Full Text |PDF (909 KB) | Open Access Article
Evaluation on Antibacterial Activity and Hepatoprotectivity of Rauwolfia serpentina
Gnanasekaran Ashok1,6*, Yukshna A/P Ramunaidu2, Fouad saleih R.AL-Suede3,4 Murugesan Karthikeyan1, Pugazhandhi Bakthavatchalam5, Sajeewa P. Rathnayake6
The results of this study provide scientific evaluation of antibacterial activity and hepatoprotective effect of Rauwolfia serpentina which will be useful to researchers investigating the compounds with this potential and encouraging the development of new findings in this field.
Abstract | Full Text |PDF (556 KB) | Open Access Article
In Vitro Anti-Inflammatory Potential of Mangifera Indica Peels
Bhaskaran Sathyapriya1, Jayesh S Raghavendra2, Swamikannu Bhuminathan3, Adugula Chandrakala4, Kesavaram Padmavathy5*, Bharathwaj D K6, Indhumathi Krishnaswamy6
This study determined Mangifera indica peels' significant anti-inflammatory effects, supporting their use in natural remedies and sustainable practices.
Abstract | Full Text |PDF (163 KB) | Open Access Article
Aishath Thahuseen Waheed1, Thurga Ayavoo2,3, Karthikeyan Murugesan2,3, Fouad Saleih R. AL-Suede4,5, Ashok Gnanasekaran2,3*
Development of anti-inflammatory herbal drug.
Abstract | Full Text |PDF (464 KB) | Open Access Article
Fouad Saleih R. Al-Suede1*, Mohamed B. Khadeer Ahamed1, Aman S. Abdul Majid2 Sultan Ayesh Mohammed Saghir3, Chern E. Oon4, Amin Malik Shah Abdul Majid1,5*
C5OSEW5050ESA OS strongly curbs variety of angiogenesis modulators in vitro, ex vivo and in vivo.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Rafida Kh. Ahmed A, M. Syarhabilahmad A, Midhat Nabil A, Fouad Saleih R. Al –Suede B,*
Oral treatment with encapsulated plant extract Ficus deltoidea and Gynocthodes sublanceolata did not appear adverse side effect and it is safe to use for therapeutic purposes.
Abstract | Full Text |PDF (852 KB) | Open Access Article
Extract of Urgenia grandiflora inhibited breast cancer cell (MCF-7) proliferation and tumorgenesity
Ibrahim B. E. El Bashir A,B, Loiy Elsir Ahmed HassanC, Amin M. S. Abdul Majid D, Sakina Yagi A*
U. grandiflora could be a new source of chemotherapeutic for breast cancer.
Abstract | Full Text |PDF (3 MB) | Open Access Article
Loiy Elsir Ahmed Hassan a, b*, Foud S. Al-Suade a, Samah M.Fadul c, Amin Malik Shah Abdul Majid a
Anogeissus leiocarpus is a traditional medicinal plant, used to treat diarrhea, fever, coughs, rheumatism, leprosy, wounds and skin diseases and psoriasis. This study was aimed to investigate the antiangiogenic and cytotoxic effects of six extracts from Anogeissus leiocarpus (leaves and bark).
Abstract | Full Text |PDF (2 MB) | Open Access Article
Sa’adiah Mohd. Yusoff a*, Mohd Zaini Asmawi a, Amin Malik Shah Abdul Majid a, b, Mohamed Khadeer A. Basheer c, Shazmin Kithur Mohamed a, Muhammad Asif a, Seyedeh Fatemeh Jafari a, Hussein Mahfoudh Baharetha a, d
Crinum asiaticum is used traditionally to treat inflammations and tumours. The aim of this work is to ascertain the scientific viability of its use in traditional medicine as an anti-tumour (potential anti-cancer) agent.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Reviews
Natural Products & Pharmacognosy
Nafiz Tareq Hasnain1*, Pallab Paul2
This study demonstrates that dietary bioactive compounds play a significant role in reducing the risk of chronic diseases, improving cardiovascular health, and offering protective effects against certain types of cancer.
Abstract | Full Text |PDF (5 MB) | Open Access Article
Ismail M. A. M. Shahhat1*, Ahmad M. Abdel-Mageed1*, Salma Yousif Sidahmed Elsheikh1, Abdelrahman T. Abdelwahab1, Marwa A. Abdelfattah1, Sally A. Elsherbeny1, Ali M. Ali2
This review discusses the potential of amino acids and polyamines in enhancing stress tolerance and improving medicinal plant resilience.
Abstract | Full Text |PDF (406 KB) | Open Access Article
Natural Polyphenol-Rich Inhibitors of Pancreatic Lipase for Obesity Management – A Systematic Review
Kamran Javed Naquvi 1*
This review discusses the plant-derived pancreatic lipase inhibitors as potential for natural, effective obesity management, reducing fat absorption and promoting metabolic health.
Abstract | Full Text |PDF (507 KB) | Open Access Article
Ethnomedicinal and Pharmacological Significance of Syzygium aromaticum (Clove): A Review
Javed Ahamad 1*
This review highlights the diverse medicinal properties of clove, supporting its potential in treating various health conditions.
Abstract | Full Text |PDF (326 KB) | Open Access Article
Subasini Uthirapathy 1*
This review highlights oleocanthal’s unique pharmacological properties, emphasizing its therapeutic potential in cancer, inflammation, Alzheimer's, and microbial infections.
Abstract | Full Text |PDF (422 KB) | Open Access Article
Mechanisms and Future Perspectives of Curcumin in Diabetes Management
Kamran Javed Naquvi 1*
This review emphasizes curcumin's multifaceted roles in managing diabetes and its complications, highlighting the need for improved formulations to enhance efficacy.
Abstract | Full Text |PDF (570 KB) | Open Access Article
Ghazal Abdullahi Olawale 1, Nozlena Abdul Samad 1*, Muath H. S. Helal 2
This review highlights the potential of flavonoids as therapeutic agents in liver cancer, focusing on HepG2 cell models.
Abstract | Full Text |PDF (298 KB) | Open Access Article
Tonny Cortis Maigoda1*, Judiono Judiono2, Felix Zulhendri3,4, Meriwati Meriwati1, Rustam Aji1
This study demonstrated nanoencapsulation for effective delivery of Peronema canescens extract to reduce ARDS-related inflammation offers potential advancements in respiratory disease management.
Abstract | Full Text |PDF (795 KB) | Open Access Article
Resveratrol in Wound Healing Application: Cellular Effects, Mechanisms, and Dressing Innovations
Nurfatin Mutalib1, Rabiatul Basria S. M. N. Mydin1, 2**
This review discusses the Resveratrol's therapeutic potential in wound healing by reducing inflammation, oxidative stress, and microbial infections, promoting tissue repair.
Abstract | Full Text |PDF (225 KB) | Open Access Article
Oluwafemi Shittu Bakare 1*, Alonge Oluwatominsin Mary 1
This review describes hops' traditional medicinal uses and their emerging biomedical applications, emphasizing their anti-inflammatory, antioxidant, and chemopreventive potential.
Abstract | Full Text |PDF (918 KB) | Open Access Article
Mohd Hasan Mujahid 1, Tarun Kumar Upadhyay 1*, Vijay Jagdish Upadhye 2*
Plant-derived phytocompounds are prominent in combating problematic multidrug-resistant (MDR) bacteria groups.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Review on Angiogenesis Modulation by Natural Compounds as Therapeutic Potential and Mechanisms
Jegathambigai Rameshwar Naidu 1* , Sasidharan Sreenivasan 2, Sakina Ruhi 1, Hana W. Jun Chen 1, Sanjith Rameshwar Naidu 1, Danish Khan 3, Thin Thin Aung 1, Mya Mya Thwin 1, Husni Ahmed Al-Goshae 1, Subramanian Rammohan 1
Compounds derived from plants that have antiangiogenic effects could be used in the development of drugs that target this stage of angiogenesis.
Abstract | Full Text |PDF (207 KB) | Open Access Article
Rasmita Jena 1,2, Durga Madhab Kar 1*, Sovan Pattanaik 1, Bhisma Narayan Ratha 3
This review emphasizes the rich potential in traditional practices, offering valuable insights and solutions to current healing challenges.
Abstract | Full Text |PDF (934 KB) | Open Access Article
Unlocking Nature’s Treasure Trove: Exploring Microorganisms for Novel Bioactives
Tasbir Amin1, Abu Bakar Karim1, Israk Iram Oyshe1, Amana Hossain1, Tafsir karim1, Jinath Sultana Jime1, Nayeema Bulbul1, Md. Asaduzzaman Shishir2, Ashrafus Safa3, Md. Fakruddin1*
Abstract | Full Text |PDF (299 KB) |Supplementary Material | Open Access Article
Moringa oleifera's Effect on Colorectal Cancer
Rolla Al-Shalabi 1,2, Nozlena abdul samad 1*, Lim Vuanghao 1, Ibrahim Al Deeb 2, Julia Joseph 1
The therapeutic benefit of Moringa plant in cancer treatment
Abstract | Full Text |PDF (2 MB) | Open Access Article
A review of the effects of Calophyllum spp. on cancer cells
Melissa Kilus1, Nozlena Abdul Samad1*, Shaari Daud2
Abstract | Full Text |PDF (225 KB) | Open Access Article
Efficacy of Herbal Medicine as Adjunctive Therapy for Skin Cancer
Norbayu Mansor1, Julia Joseph1, Rola Al Shalabi1, Nozlena Binti Abdul Samad*1
Phytochemicals can be used for skin cancer prevention and treatment.
Abstract | Full Text |PDF (373 KB) | Open Access Article
Ibrahim Al-deeb1,2,3, Julia Joseph1, Amin Malik Shah Abdul Majid2, Nozlena Abdul Samad1
Abstract | Full Text |PDF (289 KB) | Open Access Article
Phytochemicals in Cancer with Special Emphasis on Ovarian Cancer
Meher U Nessa1,2, Md S Anwar1, Fazlul Huq3*
Reviews current literature on use of phytochemicals in prevention and therapy of ovarian cancer including mechanism of action.
Abstract | Full Text |PDF (1 MB) |Supplementary Material | Open Access Article
Modes of Anti-angiogenesis in Chemical Perspectives
Shan Arif a, b, Muhammad Imran a, b, Muhammad Adnan Iqbal a, b
In the current study, role of synthesized chemical pharmacores like Humulus lupulus, Hypericum perforatum, Panax ginseng, Coptis chinensis and Rheum palmatum (Varinska et al., 2010) as anti-angiogenesis has been compiled.
Abstract | Full Text |PDF (3 MB) | Open Access Article
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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RETRACTED ARTICLE: Predicting Parkinson’s Disease Progression Using Statistical And Neural Mixed Effects Models: Comparative Study On Longitudinal Biomarkers
This study demonstrates interpretable, robust modeling for Parkinson’s telemonitoring, guiding reliable disease progression prediction under small-sample longitudinal data constraints.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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An Integrated AI-Driven Framework for Maternal Resource Intelligence Shortages Across U.S. Hospital
Integrating predictive analytics, reinforcement learning, and causal inference improves maternal outcomes by aligning risk prediction with real-time, equity-aware resource allocation decisions.
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Serum Uric Acid Reduction Following Use of Canssu5®, a Standardized Orthosiphon stamineus Extract, in Adults with Hyperuricemia: A Retrospective Case Study
This study provides preliminary clinical evidence that standardized Orthosiphon stamineus extract may meaningfully reduce serum uric acid in hyperuricemic adults.
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Comprehensive Review of Foundation Toxicity Models Integrating In Vivo, In Vitro, and Chemical Knowledge for Unified Risk Prediction
Bridges experimental and computational toxicology to enable predictive, human-relevant risk assessment frameworks for safer and faster chemical evaluation
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Integrative Molecular and Microbial Mechanisms Linking Liver Fibrosis, Cancer Biology, and Host-Microbe Interactions
This study integrates biomedical and ecological research, revealing shared biological mechanisms that inform therapeutic innovation, sustainable agriculture, and systems-level understanding of complex biological interactions.
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Dietary Bioactive Compounds in Cancer and Cardiovascular Health: A Systematic Review of Methylxanthines, Polyphenols, and Flavonoids
This study demonstrates that dietary bioactive compounds play a significant role in reducing the risk of chronic diseases, improving cardiovascular health, and offering protective effects against certain types of cancer.
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Therapeutic Angiogenesis: From Single-Factor Failures to Precision Vascular Regeneration
Multimodal, precision-guided angiogenic therapies—gene, cell, extracellular vesicle, and biomaterial-based—offer transformative potential for treating ischemic diseases where revascularization remains unfeasible.
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Epigenetic Clocks and Biological Ageing: From Biomarker to Intervention Target
Epigenetic clocks convert DNA methylation into a modifiable biomarker, repositioning ageing as a treatable clinical target.
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Mapping the Invisible Architecture of Disease: Spatial Multi-Omics Technologies, Computational Integration, and the Path Toward Clinical Translation
Spatial multi-omics repositions tissue context as a first-class clinical variable, but equitable, standardized translation remains unfinished business.
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Why Artificial Intelligence Models for Antimicrobial Resistance Still Fail at the Bedside: A Review of Validation, Explainability, and Equity Gaps
Explains why highly accurate AI resistance models fail clinically, and outlines concrete validation, equity, and deployment fixes.
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Single-Cell and Spatial Transcriptomics in Precision Diagnostics: A Roadmap for Clinical Adoption
Spatial transcriptomics reveals disease architecture at cellular resolution, but cost, FFPE limits, and complexity keep it from routine clinical diagnostics.
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From Days to Hours: Artificial Intelligence in Antimicrobial Resistance Diagnostics and Drug Discovery, and Why No Tool Has Yet Reached the Clinic
AI compresses AMR diagnosis and discovery timelines dramatically, yet no tool has reached regulatory clearance — validation and trust, not algorithms, remain the bottleneck.
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The Gut–Brain–Immune Axis in Chronic Disease: Mechanisms and Therapeutic Opportunities — A Narrative Synthesis
This review reframes chronic neurodegenerative and autoimmune disease through a reproducible, microbiome-centered mechanistic and therapeutic lens.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.
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Extracellular Vesicles as Diagnostic and Therapeutic Tools: Closing the Translational Gap
Extracellular vesicles promise cell-free precision diagnostics and therapeutics, but standardization, scalability, and regulatory gaps still block routine clinical adoption.
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Senescent Cell Heterogeneity and Precision Clearance Strategies: From Molecular Mechanism to Clinical Translation
Mapping senescent-cell heterogeneity to precision senotherapies could transform multimorbid, age-related disease treatment safely
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Obesity Pharmacotherapy in the GLP-1 Era: Efficacy, Equity, and the Long-Term Unknowns of Incretin-Based Care
Bariatric-level pharmacotherapy now exists, yet muscle loss, rebound, cost, and pediatric uncertainty still limit its real-world promise.
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Organoid-on-Chip Platforms as Predictive Models of Human Disease: Promise and Pitfalls
Organoid-on-chip systems merge biological fidelity with engineering precision, offering AI-augmented, human-relevant platforms positioned to reshape preclinical drug development.
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Mitochondrial Transfer Between Cells: Physiological Roles and Therapeutic Potential
Intercellular mitochondrial transfer sustains tissue bioenergetics and immunity, offering a transformative, biologically grounded therapeutic strategy for degenerative and ischemic disease.
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Tissue-Resident Memory T Cells in Health and Disease: Emerging Regulators of Immunity
Tissue-resident memory T cells permanently guard peripheral organs, but their dysregulation drives chronic autoimmune disease, making them a precise emerging therapeutic target.
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Multimorbidity in Ageing Populations: Redefining Clinical Guidelines for Combined Disease Management
Frailty-based, mechanism-anchored prescribing frameworks could replace single-disease guidelines that quietly harm complex older patients.
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Long COVID as a Network Disorder: Mechanisms, Biomarkers, and the Path Toward Mechanism-Anchored Clinical Stratification
Reframing Long COVID as a biologically stratifiable network disorder could finally make targeted, effective treatment trials possible.
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Emerging CRISPR-Cas, Antibody, and Nanomedicine Strategies Against Antimicrobial Resistance in Critical Care
AMR is outpacing critical-care antibiotics; precision genomic, antibody, peptide, and nanozyme strategies may restore therapeutic options.
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Integrating Genomics, Transcriptomics, and Organoid-Based Drug Testing for Precision Cancer Care
Integrating transcriptomic, epigenetic, and functional organoid data with genomics may finally close oncology’s persistent gap between diagnosis and matched treatment.
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Digital Biomarkers and Wearable Bioelectronics Across Neurological, Cardiopulmonary, and Mental Health Conditions: Clinical Evidence and Barriers to Adoption
Wearable digital biomarkers show strong clinical validity but require standardized validation, interoperable data systems, and equitable design before routine adoption.
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Modifiable Triggers and Autoimmune Disease Flares: A Mechanistic and Clinical Synthesis of Molecular Mimicry, Barrier Disruption, and Neuroendocrine-Microbial Crosstalk
Environmental exposures converge with genetic risk to trigger autoimmune flares, guiding precision prevention beyond genetics alone.
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Artificial Intelligence in Precision Cardiovascular Medicine: Risk Prediction, Digital Twins, and Explainability
Artificial-intelligence risk models and digital twins could shift cardiology from reactive treatment toward proactive, individualized prevention — if bias, validation, and trust gaps are honestly addressed.
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Moving Beyond the Double-Strand Break Through CRISPR-Based Epigenome Editing for Specificity-Driven Sickle Cell Disease Therapy
Epigenome editing may silence sickle-globin defects without DNA cleavage, offering a safer, durable alternative to nuclease-based gene therapy.
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Non-Coding RNA Networks in Pancreatic Ductal Adenocarcinoma: An Expanding Regulatory Landscape from the ceRNA TRIAD to Exosomal Immune Evasion and Ferroptosis Escape
Non-coding RNA networks orchestrate pancreatic cancer progression, immune evasion, and chemoresistance, revealing druggable nodes for precision therapy.
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Liquid–Liquid Phase Separation as a Unifying Biophysical Driver of Proteinopathy in ALS and Frontotemporal Dementia: Mechanisms, Molecular Grammar, and Therapeutic Vulnerabilities
Mapping how ALS/FTD proteins phase-separate and solidify reveals shared biophysical vulnerabilities that could be therapeutically exploited across the disease spectrum.
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RNA Modifications Reprogram the Epitranscriptome to Drive Hepatocellular Carcinoma Progression
RNA modifications reprogram liver-cancer transcripts to drive growth, immune escape, and drug resistance—offering new biomarkers and druggable targets.
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Protein Language Models for Predicting BRCA1/BRCA2 Variant Pathogenicity: A Computational Bridge Toward Precision Oncology
Protein language models can resolve uncertain BRCA variants rapidly, potentially widening equitable access to PARP-inhibitor therapy worldwide.
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Chromatin Architecture Disruption Drives Transcriptional Dysregulation and Reveals Therapeutic Vulnerabilities in Acute Myeloid Leukaemia
STAG2/cohesin loss and oncofusion proteins collapse 3D chromatin loops in AML, silencing differentiation genes while revealing druggable, reversible epigenetic vulnerabilities.
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Cellular Senescence as a Pathogenic Hub Driving Mechanistic Networks and Reversal Strategies in Idiopathic Pulmonary Fibrosis
Cellular senescence organizes IPF pathogenesis across cell types, positioning senotherapeutics and regenerative cell therapy as biologically grounded strategies for reversing, not merely slowing, fibrosis.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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