Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles in following topics:
- Molecular & Cellular Biomedicine
- Pharmacology & Drug Discovery
- Clinical & Translational Medic
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Integrative Biomedical Research
Table of Contents
Case Study
Biomedical sciences
Shanmathi R1, Rajprabha2, Prem kumar J3, Rajashree V 4*
This case determines the rare occurrence of thrombotic microangiopathy in dengue fever, emphasizing the need for awareness and early diagnosis.
Abstract | Full Text |PDF (129 KB) | Open Access Article
Ramesh T V1, Gopi Ayyaswamy2, Zioni Sangeetha3 and Vinod Kumar P 4*
This case determines the importance of early diagnosis and treatment of rare cold agglutinin-induced hemolytic anemia in systemic lupus erythematosus.
Abstract | Full Text |PDF (140 KB) | Open Access Article
Kannan N1, Prabhu K2, Jamunarani A3, Thatiparthi Stephen*4
This case determines the rare but critical progression from localized Bullous Impetigo to severe Staphylococcal Scalded Skin Syndrome, emphasizing the importance of vigilant diagnosis and timely treatment.
Abstract | Full Text |PDF (125 KB) | Open Access Article
Rare Case of Mature Teratoma in the Greater Omentum: Diagnostic and Surgical Challenges
Brigida S 1, Parijatham S 2, Lakshmi Prabha M 3, Saravanan K 4*
This rare case of greater omental teratoma determines diagnostic challenges and underscores the importance of surgical intervention for accurate diagnosis and treatment.
Abstract | Full Text |PDF (132 KB) | Open Access Article
Sushma1, Nandipatti2, Mary Chandrika3, Aljin V 4*
This case determines the importance of recognizing clinical and radiological features of RCDP for early diagnosis in limited-resource settings.
Abstract | Full Text |PDF (140 KB) | Open Access Article
The Complexities of Neuropsychiatric Lupus: Pathogenesis, Diagnosis, and Management
Ramesh T V1, Gopi Ayyaswamy2, Zioni Sangeetha3, Vinod Kumar P 4*
This case determines the critical need for early diagnosis and aggressive treatment of CNS vasculitis in SLE to achieve remission.
Abstract | Full Text |PDF (215 KB) | Open Access Article
Vidhya N1, Durga Devi G2, Shenbaga Lalitha S3, Swetha N B4
This study shows a rare co-infection of scrub typhus and CMV encephalitis in immunosuppressed patients, underscoring diagnostic challenges and treatment strategies.
Abstract | Full Text |PDF (384 KB) | Open Access Article
Yogarajan R 1, Jayakumari S 2, Sumathi K 3, Mohan Kumar P R 4*
This case showed the necessity of thorough diagnostic reevaluation in persistent asthma to uncover potential alternative diagnoses like carcinoid tumors.
Abstract | Full Text |PDF (127 KB) | Open Access Article
Early Diagnosis and Management of Neonatal Acute Hematogenous Osteomyelitis: A Case Report
Sushma1, Nandipatti2, Mary Chandrika3, Aljin V*4
This study determines the importance of early diagnosis and aggressive treatment in neonatal acute hematogenous osteomyelitis to prevent severe complications.
Abstract | Full Text |PDF (140 KB) | Open Access Article
Ramya Ravichandar1, Rajam Krishna S2, Priya Sivashankar3, and Sujai Anand*4
This case determines a rare co-occurrence of gastric adenocarcinoma in a TSC patient, urging consideration of malignancies in TSC management.
Abstract | Full Text |PDF (282 KB) | Open Access Article
Ramya Ravichandar1, Rajam Krishna S2, Priya Sivashankar3, Sujai Anand*4
This study shows rare spontaneous conception in mosaic Turner syndrome, emphasizing early fertility counseling and multidisciplinary pregnancy management.
Abstract | Full Text |PDF (132 KB) | Open Access Article
Cardiovascular Manifestations of Leptospirosis: A Case of Myopericarditis in an Endemic Region
Jayakanthan S 1, Manimaran R 1, Sathyanarayanan M 1*, Bharathi Raja K 1
This study showed the need for cardiovascular evaluation in leptospirosis patients, especially in endemic areas, to prevent severe cardiac complications.
Abstract | Full Text |PDF (130 KB) | Open Access Article
Vishnuvarthan R S 1, Valarmathy M 1, Suresh Babu P 1*, Karthikeyan C T 1
This case showed the critical need for differential diagnosis between acute aortic syndrome and myocardial ischemia to ensure timely and effective treatment.
Abstract | Full Text |PDF (127 KB) | Open Access Article
Nikath Nasreen N 1, Kaavya M 1, Logeswari B M 1, Blessy John 1*
This case showed the need for awareness of rare myocardial infarction causes, such as coronary artery dissection and heparin-induced thrombocytopenia, highlighting complex diagnostic and management challenges.
Abstract | Full Text |PDF (137 KB) | Open Access Article
Catastrophic Colorectal Injuries Due to Misuse of Compressed Air: A Case Report and Review
Pugazharasan M 1, Aluru Jayakrishna Reddy 1, Manikandan R S 1, Arul M 1*
This case describes the severe risks of using compressed air for sexual stimulation, highlighting the urgent need for improved safety awareness and preventive measures.
Abstract | Full Text |PDF (305 KB) | Open Access Article
Lakshmi K 1, Dinesh K 1, Bindu D 1*, Sharanya K 1
Early diagnosis and surgical management of Familial Adenomatous Polyposis (FAP) are crucial for preventing colorectal cancer, highlighting the need for vigilant surveillance and timely intervention.
Abstract | Full Text |PDF (135 KB) | Open Access Article
Pugazharasan M 1, Aluru Jayakrishna Reddy 1, Manikandan R S 1, Arul M 1*
Early diagnosis and surgical intervention in congenital glaucoma are crucial to preventing irreversible vision loss in pediatric patients.
Abstract | Full Text |PDF (687 KB) | Open Access Article
Lakshmi K 1, Dinesh K 1, Bindu D 1*, Sharanya K 1
This case report determined the complexity of diagnosing and managing GBS in immunocompromised patients, highlighting the critical role of parvovirus B19 in such cases and emphasizing the need for comprehensive viral investigations.
Abstract | Full Text |PDF (131 KB) | Open Access Article
Srivalsa Bhaskaran 1, Kamaal Mohideen Khan 1, Karthik V 1, Mani Shanthini 1*
This case showed the reversible nature of renal impairment in hypothyroidism, emphasizing the importance of timely thyroid hormone replacement therapy.
Abstract | Full Text |PDF (124 KB) | Open Access Article
Scurvy in a Pediatric Patient with Restrictive Eating for Dietary Management - Case Study
Sri vamsi krishna 1, Nabeel Nazeer 1, Bharath A S 1, Magesh C 1*
This case determined the importance of addressing restrictive eating patterns and dietary limitations in children, particularly those with special needs, to prevent vitamin C deficiency and support overall health.
Abstract | Full Text |PDF (131 KB) | Open Access Article
Research Article
Biomedical sciences
T. Sangeetha 1*, K. Manikandan 1, D. Victor Arokia Doss 2
This study determined an advanced deep learning model optimized for early and accurate cardiomyopathy classification, addressing issues like overfitting and high dimensionality in gene expression data.
Abstract | Full Text |PDF (603 KB) | Open Access Article
Assessing Knowledge Gaps on Diabetes Prevention Among Biology Graduates: A Study in Pondicherry
Samyuktha P 1, Pugazharasan 1*, Kuberan 1
This study determined critical gaps in preventive diabetes knowledge among biology graduates, highlighting the need for improved educational strategies on root causes and prevention.
Abstract | Full Text |PDF (138 KB) | Open Access Article
Bharathwaj D K 1*, Indhumathi Krishnaswamy 1, Arun Shriram A 1, Shreevithya D 1
This study showed the superior functional recovery and reduced complications associated with bipolar hemiarthroplasty compared to Austin Moore prostheses in elderly patients.
Abstract | Full Text |PDF (265 KB) | Open Access Article
Umashankar R 1, Sundarrajan K 1, Anupama K A 1, Prathiba B 1*
This study showed insights into SSI rates, associated risk factors, and microbial profiles, informing targeted interventions to improve surgical outcomes and infection control.
Abstract | Full Text |PDF (168 KB) | Open Access Article
Nandini M S 1, Priya Santharam 1, Bindu D 1*, Priya V 1
GGT showed high sensitivity and specificity for diagnosing metabolic syndrome, aiding early detection and management to reduce cardiovascular risks.
Abstract | Full Text |PDF (147 KB) | Open Access Article
Dental Office Noise as Key Trigger of Anxiety in Children, Advocates Non-Invasive Solutions
Bhaskaran Sathyapriya1, Swamikannu Bhuminathan, 2 Jayesh S Raghavendra3*, Adugula Chandrakala 4, Geo Danny C5, Vignesh N R5
This study showed noise as a significant trigger of dental anxiety in children, suggesting non-invasive techniques to enhance pediatric dental care.
Abstract | Full Text |PDF (358 KB) | Open Access Article
Extract of Urgenia grandiflora inhibited breast cancer cell (MCF-7) proliferation and tumorgenesity
Ibrahim B. E. El Bashir A,B, Loiy Elsir Ahmed HassanC, Amin M. S. Abdul Majid D, Sakina Yagi A*
U. grandiflora could be a new source of chemotherapeutic for breast cancer.
Abstract | Full Text |PDF (3 MB) | Open Access Article
Li-xin XU A, Xiao-bo XIA B, Aman Shah Abdul Majid C, Dan Ji B
This study provides insight to EDHF-mediated vasomotor response, as well as various eye disorders caused by dysfunctional retinal arteries, like central retinal artery occlusion.
Abstract | Full Text |PDF (971 KB) | Open Access Article
Reviews
Biomedical sciences
Md. Shohayeb Hossain Saif1*
This study demonstrated the need for robust surveillance, innovative therapeutics, and multidisciplinary approaches to combat infectious diseases and future pandemics.
Abstract | Full Text | Open Access Article
Moniruddin Chowdhury1,2, Syeda Humayra2, Sohel Mahmud3, Yukihito Higashi4, YD Singh1
PAD and its impact in physical impairment or mortality.
Abstract | Full Text |PDF (201 KB) | Open Access Article
Targeting Microtubules by Phytoestrogens for the Treatment of Cancer: An Overview
Fan Xu1, Nozlena Abdul Samad1, Nurhuda Mohamad Ansor1*
In this review, we summarize reported effects of some phytoestrogens that bind directly to tubulin at various binding site and disrupt the microtubule dynamics, either by promoting microtubule polymerization or enhancing microtubule depolymerization.
Abstract | Full Text |PDF (737 KB) | Open Access Article
Sasi Kumar S 1, Gopinath S 2, Kalaichezhian M 3, Harish M 4*
This study demonstrates the effectiveness of strict surgical protocols during COVID-19, ensuring patient and staff safety during emergency surgeries.
Abstract | Full Text |PDF (134 KB) | Open Access Article
Manimekalai P 1, Suresh Kanna S 1, Vijaykumar Edward 1 Anandan P 1*
This meta-analysis clarifies NLR's prognostic role in COPD, revealing its potential as a predictive marker for exacerbation and mortality.
Abstract | Full Text |PDF (143 KB) | Open Access Article
Lionel John J 1, Srinivasan N 1, Shiva P 1*, Radhakrishnan P 1
The NLR is a promising, cost-effective marker for predicting COPD exacerbations and mortality, with potential for routine clinical use.
Abstract | Full Text |PDF (150 KB) | Open Access Article
Immune Dysfunction linking hyperglycemia with periodontitis in Diabetes Management
Harini Venkata Subbiah1, Polani Ramesh Babu2, Usha Subbiah1*, Daniel Rajendran T3, Vinod Kumar P3
This review discusses the mechanisms linking hyperglycemia with periodontitis highlights the need for comprehensive management of diabetes to improve periodontal health.
Abstract | Full Text |PDF (232 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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RETRACTED ARTICLE: Predicting Parkinson’s Disease Progression Using Statistical And Neural Mixed Effects Models: Comparative Study On Longitudinal Biomarkers
This study demonstrates interpretable, robust modeling for Parkinson’s telemonitoring, guiding reliable disease progression prediction under small-sample longitudinal data constraints.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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An Integrated AI-Driven Framework for Maternal Resource Intelligence Shortages Across U.S. Hospital
Integrating predictive analytics, reinforcement learning, and causal inference improves maternal outcomes by aligning risk prediction with real-time, equity-aware resource allocation decisions.
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Serum Uric Acid Reduction Following Use of Canssu5®, a Standardized Orthosiphon stamineus Extract, in Adults with Hyperuricemia: A Retrospective Case Study
This study provides preliminary clinical evidence that standardized Orthosiphon stamineus extract may meaningfully reduce serum uric acid in hyperuricemic adults.
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Comprehensive Review of Foundation Toxicity Models Integrating In Vivo, In Vitro, and Chemical Knowledge for Unified Risk Prediction
Bridges experimental and computational toxicology to enable predictive, human-relevant risk assessment frameworks for safer and faster chemical evaluation
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Integrative Perspectives on Complex Biological Systems: Linking Liver Fibrosis, Cancer Biology, Microbial Ecology, and Agricultural Symbiosis
This study integrates biomedical and ecological research, revealing shared biological mechanisms that inform therapeutic innovation, sustainable agriculture, and systems-level understanding of complex biological interactions.
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Dietary Bioactive Compounds in Cancer and Cardiovascular Health: A Systematic Review of Methylxanthines, Polyphenols, and Flavonoids
This study demonstrates that dietary bioactive compounds play a significant role in reducing the risk of chronic diseases, improving cardiovascular health, and offering protective effects against certain types of cancer.
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Therapeutic Angiogenesis: From Single-Factor Failures to Precision Vascular Regeneration
Multimodal, precision-guided angiogenic therapies—gene, cell, extracellular vesicle, and biomaterial-based—offer transformative potential for treating ischemic diseases where revascularization remains unfeasible.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.
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Senescent Cell Heterogeneity and Precision Clearance Strategies: From Molecular Mechanism to Clinical Translation
Mapping senescent-cell heterogeneity to precision senotherapies could transform multimorbid, age-related disease treatment safely
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Organoid-on-Chip Platforms as Predictive Models of Human Disease: Promise and Pitfalls
Organoid-on-chip systems merge biological fidelity with engineering precision, offering AI-augmented, human-relevant platforms positioned to reshape preclinical drug development.
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Mitochondrial Transfer Between Cells: Physiological Roles and Therapeutic Potential
Intercellular mitochondrial transfer sustains tissue bioenergetics and immunity, offering a transformative, biologically grounded therapeutic strategy for degenerative and ischemic disease.
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Epigenetic Clocks and Biological Ageing: From Biomarker to Intervention Target
Epigenetic clocks convert DNA methylation into a modifiable biomarker, repositioning ageing as a treatable clinical target.
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The Gut–Brain–Immune Axis in Chronic Disease: Mechanisms and Therapeutic Opportunities — A Narrative Synthesis
This review reframes chronic neurodegenerative and autoimmune disease through a reproducible, microbiome-centered mechanistic and therapeutic lens.
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Mapping the Invisible Architecture of Disease: Spatial Multi-Omics Technologies, Computational Integration, and the Path Toward Clinical Translation
Spatial multi-omics repositions tissue context as a first-class clinical variable, but equitable, standardized translation remains unfinished business.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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Tissue-Resident Memory T Cells in Health and Disease: Emerging Regulators of Immunity
Tissue-resident memory T cells permanently guard peripheral organs, but their dysregulation drives chronic autoimmune disease, making them a precise emerging therapeutic target.
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Single-Cell and Spatial Transcriptomics in Precision Diagnostics: A Roadmap for Clinical Adoption
Spatial transcriptomics reveals disease architecture at cellular resolution, but cost, FFPE limits, and complexity keep it from routine clinical diagnostics.
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Extracellular Vesicles as Diagnostic and Therapeutic Tools: Closing the Translational Gap
Extracellular vesicles promise cell-free precision diagnostics and therapeutics, but standardization, scalability, and regulatory gaps still block routine clinical adoption.