Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles in following topics:
- Molecular & Cellular Biomedicine
- Pharmacology & Drug Discovery
- Clinical & Translational Medic
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Integrative Biomedical Research
Table of Contents
Research Article
Biomedical Engineering & AI in Healthcare
Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
Moin Uddin Patwary1*, Tanjila Hasan Tulon1, Shamim Al Mamun1, Md. Mortuza Galib1, Ezaz Ahmad Shah1, Antu Das2, Rudro kumar Saha1, Sabrina Sultana Sneha1, Arobi Akter Mim1, Jinia1
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
Abstract | Full Text |PDF (878 KB) | Open Access Article
Zulfayandi Pawanis1, Heroe Soebroto2, Dhihintia Jiwangga2, Yan Efrata Sembiring, Puruhito2
SDS significantly reduces type I and III collagen density in decellularized bovine pericardium, whereas H2O2 better preserves extracellular matrix integrity.
Abstract | Full Text |PDF (344 KB) | Open Access Article
Rajalekshmy K.D 1*, E.J. Thomson Fredrik 1
Improves early cerebral palsy detection by resolving pose occlusions through enhanced skeleton generation and feature extraction from infant movement videos.
Abstract | Full Text |PDF (1 MB) | Open Access Article
C. Maria Sheeba 1*, K. Sarojini 2
This model offers an accurate, timely SCA detection solution, improving healthcare outcomes for Nilgiri tribes and vulnerable populations.
Abstract | Full Text |PDF (706 KB) | Open Access Article
Muhammad Rifial1, Amran Razak2, Darmawansyah Darmawansyah2, Indar Indar2, Arsyad Rahman3
This study explores how system usage, satisfaction, and quality factors influence the effectiveness of HMIS in improving hospital performance and patient care.
Abstract | Full Text |PDF (269 KB) | Open Access Article
Mobile Applications for Enhancing Safety Audits in Healthcare Construction Sites
Rubel Datta1, Pankaj Kumar Sarker2, Lima Shikdar3, Md. Halimuzzaman4, Mohammad Rezaul Karim5
This study demonstrates the potential of mobile applications to enhance safety audits in healthcare construction sites in Bangladesh.
Abstract | Full Text |PDF (168 KB) | Open Access Article
S. Ariffa Begum1*, J. Raja2, N. Srinivas3, R. Nagendran4, G. Umamaheswari5, Srithar S6
PA-C-AI enhances angiogenesis prediction, enabling precise cancer therapies and personalized treatments, improving patient outcomes and survival rates.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Wasib Bin Latif 1*, Ida Md Yasin 1, Mohammed Julfikar Ali 2, Md. Nazrul Islam 3, Md. Shak Forid 4
This study determined the transformative impact of EdTech innovations in revolutionizing research productivity, elevating educational engagement, and enhancing clinical precision within applied medical sciences.
Abstract | Full Text |PDF (203 KB) | Open Access Article
Dev Ras Pandey 1*, Ahilya Dubey 1
This study determines the ATC-CNN’s superior performance in real-time monitoring of cardiovascular patients revolutionizes care, enhancing access, accuracy, and clinical outcomes.
Abstract | Full Text |PDF (552 KB) | Open Access Article
Priya Vij 1*, Patil Manisha Prashant 1
This study determined a novel approach combining SOM and IRNN with EHSO to enhance early detection of ovarian cancer, improving diagnostic accuracy and efficiency.
Abstract | Full Text |PDF (574 KB) | Open Access Article
Abhijeet Madhukar Haval 1*, Md Afzal 1
This study demonstrated the superior potential of Web-Text Sentiment Analysis in predicting cardiovascular disease over demographic-based models.
Abstract | Full Text |PDF (427 KB) | Open Access Article
Omprakash Dewangan 1*, Ankita Tiwari 1
This research demonstrates a novel Mask R-CNN with ResNet-FPN framework for improved segmentation and classification of Diabetic Foot Ulcers, enhancing diagnostic accuracy.
Abstract | Full Text |PDF (225 KB) | Open Access Article
Bhuneshwari Dewangan 1*, Mahendra Kumar Sahu 1
This study presents a novel AR-based approach for accurate, non-invasive chronic wound evaluation, enhancing clinician-patient communication and care.
Abstract | Full Text |PDF (461 KB) | Open Access Article
Kamlesh Kumar Yadav 1*, Dhablia Dharmesh Kirit 1
This study demonstrates Radiology-specific word encodings potential in improving the performance of radiology-focused BNLP tasks using diverse word embeddings.
Abstract | Full Text |PDF (536 KB) | Open Access Article
Poorti Sharma 1*, Syed Sajid Ali Syed Sabir Ali 1
Digitizing supply chains with Blockchain technology improves transparency, reduces costs, and ensures secure medication distribution, crucial for pharmaceutical safety.
Abstract | Full Text |PDF (844 KB) | Open Access Article
Nidhi Mishra 1*, Ghorpade Bipin Shivaji 1
Combining CNN and LSTM models with feature enhancement significantly improves heart disease prediction, offering precise and timely interventions.
Abstract | Full Text |PDF (373 KB) | Open Access Article
F Rahman 1*, Lalnunthari 1
This study demonstrates that integrating machine learning with decision support systems significantly improves prescription error detection, reducing medication errors and enhancing patient safety.
Abstract | Full Text |PDF (241 KB) | Open Access Article
Salman Mohammad Abdullah1, Abdullah Al Masum2, Nayem Uddin Prince3, Labonno Akter Mim4
This study demonstrated advanced deep learning models improving ovarian cancer subtype classification, defining the way for precision medicine applications.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Machine Learning Models for Predicting Risky Pregnancies in Early Clinical Interventions
Atik Shahariyar Hasan 1, Sree Shib Shankar Devnath Debu 2, Israt Jahan Eti 3, Md. Halimuzzaman 4, Mohammad Rezaul Karim 5, Birupaksha Biswas 6
This study determined the most effective machine learning models for predicting risky pregnancies, aiding in early clinical interventions.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Mario Hendri RW1*, Heroe Soebroto 1, Ito Puruhito 1
This study showed optimal decellularization methods for enhancing porosity and pore size in bovine pericardium scaffolds, crucial for pediatric heart surgery.
Abstract | Full Text |PDF (454 KB) | Open Access Article
Yuvaraja M 1*, R. Ramesh 2, R. Priya 3, J. Dhanasekar 4
This study enhances healthcare with WBSN-PHMS, enabling continuous, real-time monitoring and early detection while optimizing energy use.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Blockchain Technology for Integrating Electronic Records of Digital Healthcare System
Md. Halimuzzaman 1, Dr. Jaideep Sharma 2, Tapan Bhattacharjee 3, Bilash Mallik 4, Rashadur Rahman 5, Mohammad Rezaul Karim 6, Mostafa Masrur Ikram 7, Md Fokhrul Islam 8
This study determined the multifaceted benefits of blockchain in enhancing the overall efficiency, effectiveness, and integrity of digital healthcare systems.
Abstract | Full Text |PDF (511 KB) | Open Access Article
Deep Learning, Particularly Convolutional Neural Network, Improves Melanoma Detection Accuracy
Adnan R. Ahmad 1*
This study demonstrated how deep learning, particularly CNNs, improves melanoma detection accuracy, supporting earlier diagnosis and better patient outcomes.
Abstract | Full Text |PDF (392 KB) | Open Access Article
Enhanced Cardiovascular Monitoring Using Radial Basis Function and Deep Belief Network Fusion
Srinivas Naveen Dolu Surabhi 1*, R.Saraswathi 2, S. Sugantha Priya 3, M. Indirani 4, Neeraj Kumar 5, S. Senthil Kumar 6
Combining RBF and DBN improves real-time cardiovascular monitoring by enhancing feature extraction and classification accuracy, addressing limitations of conventional methods.
Abstract | Full Text |PDF (427 KB) | Open Access Article
C V Keerthi Latha 1*, M Kezia Joseph 1*
Early seizure prediction via EEG signals might enable timely intervention, potentially improving patient outcomes and reducing clinical risks.
Abstract | Full Text |PDF (319 KB) | Open Access Article
T. Sangeetha 1*, K. Manikandan 1, D. Victor Arokia Doss 2
This study determined an advanced deep learning model optimized for early and accurate cardiomyopathy classification, addressing issues like overfitting and high dimensionality in gene expression data.
Abstract | Full Text |PDF (603 KB) | Open Access Article
R. Shiva Kumar 1, Joseph Prakash Mosiganti 2*
This study determined leukemia diagnostics by leveraging EfficientNetB3's transfer learning, improving accuracy and efficiency in blast cell classification.
Abstract | Full Text |PDF (531 KB) | Open Access Article
3D-Printed Resin Showed Higher Water Sorption than Heat-Cured PMMA and Polyamide
Amr A. Aliem Elbanna 1*, Nehad Mohamed Harby 1, Farid Abdelkarim Hamam 1
Evaluation of water sorption in various denture base materials, highlighting significant differences and implications for clinical durability and performance.
Abstract | Full Text |PDF (330 KB) | Open Access Article
Ensemble Deep Learning based Lung Cancer Classification Model using Gene Expression Data
V. Yuvaraj 1*, D. Maheswari 2
Precision medicine, microarray analysis, ensemble learning, and deep neural networks revolutionize lung cancer diagnosis, enhancing accuracy and treatment efficacy.
Abstract | Full Text |PDF (633 KB) | Open Access Article
S. Maria Sylviaa 1*, N. Sudha 1
Early Breast Cancer diagnosis via data mining is crucial. Proposed methods achieve high accuracy, improving treatment outcomes for patients significantly.
Abstract | Full Text |PDF (852 KB) | Open Access Article
Reviews
Biomedical Engineering & AI in Healthcare
Mst Murshida Mahbub 1*, Rabiatul Basria S. M. N. Mydin 2, Chandrarohini Saravanan 2
Closing AI's reproducibility and fairness gaps is a precondition, not an afterthought, for trusting deep-learning imaging tools at the bedside.
Abstract | Full Text |PDF (250 KB) | Open Access Article
Md. Kaium 1*, Suhel Ahmed 2
Explains why highly accurate AI resistance models fail clinically, and outlines concrete validation, equity, and deployment fixes.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Mohamed Khadeer A. Basheer 2, Shazmin Kithur Mohamed 1, Muhammad Asif 1, Seyedeh Fatemeh Jafari 1
Artificial-intelligence risk models and digital twins could shift cardiology from reactive treatment toward proactive, individualized prevention — if bias, validation, and trust gaps are honestly addressed.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Adesh Kolapkar 1*, Ramji Gupta 2
Wearable digital biomarkers show strong clinical validity but require standardized validation, interoperable data systems, and equitable design before routine adoption.
Abstract | Full Text | Open Access Article
Organoid-on-Chip Platforms as Predictive Models of Human Disease: Promise and Pitfalls
Usha Subbiah1*, Harini Venkata Subbiah1,
Organoid-on-chip systems merge biological fidelity with engineering precision, offering AI-augmented, human-relevant platforms positioned to reshape preclinical drug development.
Abstract | Full Text | Open Access Article
Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
Yue Li¹*, Shunqi Liu2 *, Ran Tong³, Pengfei Zhang4, Jiang Bian5, Tong Wang6, Panpan Gu7
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
Abstract | Full Text |PDF (533 KB) | Open Access Article
AI-driven Innovations in Cancer Research and Personalized Healthcare
Rabi Sankar Mondal1*, Md Nazmul Alam Bhuiyan1, Lamia Akter2
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
Abstract | Full Text |PDF (683 KB) | Open Access Article
K M Sadat Samin1*, Soraya Sadek2
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
Abstract | Full Text |PDF (350 KB) | Open Access Article
Artificial Intelligence and Digital Health Technologies in Emergency Response Systems
Saed Khalid Salih Alharbi 1, Abdulrhman Abdullah Nazzal Alenazi 1, Majed Suliman Alwalie 1, Abdullah Saleh Abdullah Almorshed 1, Khalid Ghattar Naif Alruways 1, Abdullah Abdulrahman Mohammed Alrbian 1, Eissa Alhumaidi Almuterie 1, Abdulmajeed Muhayya Almutairi 1, Ghadyan Salem Alshammari 2, Muteb Freeh Saleman Alshammari 2, Moteb Rshid Aswi Alshammari 2, Sultan Faris Rasheed Alshammari 2, Bashair Maqbool Sulaiman Alharbi 3, Abdullah Faraj B. Alosimi 1, Shaima Abdullah Bukhamsin 1, Ahmad Mohammed Alharbi 1
This review clarifies how AI and digital technologies realistically improve emergency response, while identifying ethical, operational, and data challenges for responsible implementation.
Abstract | Full Text |PDF (301 KB) | Open Access Article
Machine Learning in Healthcare: From Diagnostics to Personalized Medicine and Predictive Analytics
Md Habibur Rahman 1, Tanjila Islam 2, Md. Emran Hossen 3, Md. Estehad Chowdhury 4, Rezaul Hayat 5 , Md Shihab Sadik Shovon 6, Hasan - Al - Shabbir 7, Mohammad Alamgir 8, Sumi Akter 9, Redoyan Chowdhury 10, Atiqur Rahman Sunny 10*
Machine learning transforms healthcare through accurate diagnosis, tailored therapies, and predictive analytics, promoting a future of precision medicine.
Abstract | Full Text |PDF (189 KB) | Open Access Article
Machine Learning for Cardiovascular Healthcare: Opportunities, Challenges, and the Path Forward
Bayazid Hossain 1, Tanveer Ehsan Chowdhury 2, MD. Amir Hossain Fahad 3, Md. Emran Hossen 4, Rafiu Ahmed 5, Aolatun Nesa 6, Mahi Nur 7, Fuad Mohammad Rafiq 8, Md. Abu Sufian 9, Nasrullah Masud 10, Nafis Tasnim Turjo 11, Atiqur Rahman Sunny 12*
Machine learning improves healthcare efficiency; yet issues such as data privacy and bias must be resolved for ethical, scalable, and effective application.
Abstract | Full Text |PDF (257 KB) | Open Access Article
Md Habibur Rahman1, Tanjila Islam2, Mohammad Hamid Hasan Amjad3, Md Shihab Sadik Shovon3, Md. Estehad Chowdhury4, Md Rahatul Ashakin5, Bayazid Hossain6, Proshanta Kumar Bhowmik3, Md Nurullah7, Atiqur Rahman Sunny8*
IoT revolutionizes healthcare by enhancing patient monitoring, treatment, and accessibility while addressing challenges in efficiency, cost, and security.
Abstract | Full Text |PDF (751 KB) | Open Access Article
Ishita Singha1, Bani Kumar Jana1, Niva Rani Gogoi1, Hemanta Pathak1, Mohini Singh1, Bhaskar Mazumder1*
This review discusses the use of gelatin sponges for safer, more effective, and affordable wound dressings for improved clinical outcomes.
Abstract | Full Text |PDF (334 KB) | Open Access Article
Salman Ghazi Al-Faridi 1*, Saqer Tawfiq Saeed M 1, Ahmed Saleh Alghamdi 1, Aseel hasson alhasson 1, Faisal Khashman Alosiml 1, Zaid Kalaf T Alshammari 1, Hussain Mutreb H Alshammari 1, Sultan Mesfer Faraj Alsahmah 1, Fawaz nasser dhaifallah Alotaibi 1, Salman Ghazi Al-Faridi 1, Osama Mohammed Aloufi 1, Tawfiq Saeed M Saqer 1, Tariq Abdulaziz Al-Falih 1, Awadh Awaadh Alotaibi 1
Drone-delivered AEDs significantly reduce response times for OHCAs, especially in rural areas, improving survival and offering cost-effective EMS support.
Abstract | Full Text |PDF (184 KB) | Open Access Article
Saud Tawfiq Al Shammari 1, Saad Mosluh Mohammed Alqahtani 1, Awwadh Saad Rashed Alshalawi 1, Khalid Shaman M Almutairi 1, Abdullah Thwab M Alotaibi 1, Majed Abdulrahman Bin Owaydhah Alsulami 1, Mohammed Rashed Mohammed Aldossari 1, Khalid Hussain Saeed Alahmari 1, Khalid Abdulmohsen Saad Alanazi 1, Abdulrahman Bader O Alsulami 1*
AI and predictive analytics revolutionize emergency medicine by enhancing triage, decision-making, and education, despite ethical, technical, and trust challenges.
Abstract | Full Text |PDF (475 KB) | Open Access Article
P. Daniel Sundarraj 1*, J. Raja2, R. Usha3, Arul Kumar V P4, N Sirisha5, Srithar S6
AI-driven insights into angiogenesis and inflammation can revolutionize disease prediction, biomarker discovery, and personalized therapeutic interventions.
Abstract | Full Text |PDF (413 KB) | Open Access Article
A Review of Radiology and Optical Coherence Tomography in Dental Diagnostics
Hemlata Dewangan 1*, Mahendra Kumar Sahu 1
This review assessed the advantages, limitations, and combined efficacy of radiology and OCT in dental diagnostics, enhancing imaging precision.
Abstract | Full Text |PDF (548 KB) | Open Access Article
Jameela Ahmed Alshehri 1*, Jawaher Jamaan Aldawsari 1, Seham Moteeb Al-Motairi 1, Samia hassan Alfifi 1, Amjad Aiaid Almutairi 1, Maha Mahdi Alanizi 1, Roseline Deline Davids 1, Shaden Alzahrani 1, Abrar Abdullah Ibrahim AlFardan 1, Muted Marshd Alanazi 2, Almontashri Ali Abdullah 2, Abdulrahman Saad Marzouq Albagami 2
AI enhances early detection and risk prediction of HAIs, improving patient outcomes and reducing healthcare costs despite integration and trust barriers.
Abstract | Full Text |PDF (259 KB) | Open Access Article
Advancements, Applications, and Future Directions of Artificial Intelligence in Healthcare
Syed Mosaddik Hossain Ifty 1, Farhana Irin 2, Md Shihab Sadik Shovon 3, Mohammad Hamid Hasan Amjad 3, Proshanta Kumar Bhowmik 3*, Raju Ahmed 4, Md Rahatul Ashakin 5, Bayazid Hossain 6, Mushfiq 1, Abdus Sattar 7, Redoyan Chowdhury 8, Atiqur Rahman Sunny 7*
This review discusses the AI's transformative role in healthcare, focusing on patient care, diagnostics, early detection, and cost reduction.
Abstract | Full Text |PDF (389 KB) | Open Access Article
Amiya Kumar Prusty1, Prasanna Parida2, Pradip Kumar Prusty3, Suryakanta Swain4, Bikash Ranjan Jena2*, Ram Naresh Yadav5, Sanjoy Das6, Bhisma Narayan Ratha7
This review discusses the AI to improve diagnostic accuracy in breast cancer screening, potentially reducing false positives and negatives and improving patient outcomes.
Abstract | Full Text |PDF (990 KB) | Open Access Article
M. Lincy Jacquline 1*, N. Sudha 1
This study determined advanced AI techniques for accurate CKD diagnosis, enhancing medical decision-making through efficient data analysis methods.
Abstract | Full Text |PDF (626 KB) | Open Access Article
Naif Saad Alsuwayti 1, Meshari Farzal Ashwi Alshammari 2*, Nahla maan aljuwaie 3, Entsar Yusuf Salah Alhosawy 4, Asma yousef saleh ALHawsawi 5, Fatimah sultan Aedh Alghamdi 6, Mohammed Saleh Ali Alshehri 7, Saleh said saleh alhamdan 8, Nawaf Abdullah Rashed Alqinat 9, Bashaier Ayed Alshahrani 10, Abdullah saeid Mohamed Asiry 11, Khalid Ali Sayqal Qawfash 12, Khalid Obaid L Alanazi 13
Neuromuscular disorders significantly impair mobility and stability; advanced orthoses like SCKAFOs improve walking efficiency and knee stability, enhancing life quality.
Abstract | Full Text | Open Access Article
Suryakanta Swain1, Ashirbaad Nanda2, Rudra Narayan Sahu3, Bikash Ranjan Jena2*, Rabisankar Dash4, Amaresh Prusty5, Prasanna Parida2, Abhisek Sahu2, Bhisma Narayan Ratha2
Biomaterials significantly enhance tissue repair and regeneration, offering innovative solutions in modern medicine and improving patient outcomes.
Abstract | Full Text |PDF (376 KB) | Open Access Article
Healthcare Monitoring-based IoT framework for heart disease detection and classification
J. Shafiq Mansoor 1, Kamalraj Subramaniam 2
The review discused the Healthcare Monitoring based IoT framework (HM-IoT) and determined the security rate and classification accuracy.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Radhika R. 1*, Rashima Mahajan 1
Enhancing medical image contrast improves diagnosis accuracy. COA-SCSO optimizes parameters efficiently, ensuring clearer images and better patient care outcomes.
Abstract | Full Text |PDF (676 KB) | Open Access Article
ALI Aalsaud 1*, Raghad Z. Yousif 2, 3
The novel ECG analysis method improves detection accuracy, is vital for early diagnosis of CVD, and potentially saves lives, especially in underserved regions.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Aruna Kokkula 1*, P. Chandra Sekhar 2, T. M. Praneeth Naidu 3
This study showed VGG-19 model with superior training speed, accuracy, and iteration efficiency, significantly enhancing Parkinson’s disease diagnosis from MRI images.
Abstract | Full Text |PDF (976 KB) | Open Access Article
Vishwanadham Mandala 1*, Srinivas Naveen Dolu Surabhi 2, V. R. Balaji 3, Dipak Raghunath Patil 4, Saiyed Faiayaz Waris 5, G. Shobana 6
Heart disease, responsible for millions of deaths annually, necessitates early detection. Machine Learning offers efficient, cost-effective diagnostic tools. The proposed Wild Horse Optimizer (WHO) and SVM classifier enhance heart disease forecasting, addressing critical healthcare needs.
Abstract | Full Text |PDF (489 KB) | Open Access Article
A Review of 3d Printing Model of New Blood Vessel Formation For Pharmaceutical Applications
Nidhi Mishra 1*, Priya Vij 1, Akanksha Mishra 1
Innovative synthetic blood vessels offer promising solutions for cardiovascular diseases, providing safer, more accessible treatments for aging populations
Abstract | Full Text |PDF (530 KB) | Open Access Article
A Pharmacy System Integrated with A Machine Learning Algorithm for Cardiovascular Disease Prediction
Kumar Shwetabh 1*, F Rahman 1, Sushree Sasmita Dash 1
The review explores an inclusive ML structure, vital for efficient CVD forecasting. The proposed model showcases superior accuracy, emphasizing the need for comprehensive predictive algorithms in cardiovascular health research.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Priya Vij 1, Sushree Sasmita Dash 1, Akanksha Mishra 1
Advanced integration of deep learning (AlexNet) and SVM-RBF for breast cancer diagnosis surpasses existing models, ensuring precise and reliable early detection.
Abstract | Full Text |PDF (899 KB) | Open Access Article
Abhijeet Madhukar Haval 1*, Akanksha Mishra 1, Sushree Sasmita Dash 1
Wound features impact healing; indicators like temperature, oxygen levels, and moisture influence the process. This review shows and effective at-home wound monitoring with biosensors.
Abstract | Full Text |PDF (962 KB) | Open Access Article
Advancements in Ocular Vascularization Analysis Using Deep Learning Techniques – A Systematic Review
F Rahman 1*, Akanksha Mishra 1, Sushree Sasmita Dash 1
This review shows an advanced machine learning method for efficient segmentation and classification of blood vessels in medical images, revolutionizing diagnostic precision.
Abstract | Full Text |PDF (873 KB) | Open Access Article
Physical Activity Correlates With The Aging Process in Seniors Broadly - A Review
Bhuneshwari Dewangan 1, Naina Bhoyar 2
A review of a correlation between physical activity, life satisfaction, and aging in the senior age group with Internet of Things (IoT) based Physical Activities (IoT-PA) model
Abstract | Full Text |PDF (406 KB) | Open Access Article
Identifying Thyroid Dysfunction Using Standard Laboratory Testings – A Systematic Review
Vinay Jaiswal 1, Prachi Gurudiwan 2
A ML-TDI model for thyroid dysfunction identification, addressing underdiagnosis challenges and emphasizing the importance of comprehensive assessment in care.
Abstract | Full Text |PDF (616 KB) | Open Access Article
Ashish Agarwal 1*, Sachin Pradhan 2
An IoT-based system enhancing elderly care, emphasizing QOL, independence, and support, aiding healthcare development for seniors' well-being.
Abstract | Full Text |PDF (670 KB) | Open Access Article
Bhuneshwari Dewangan 1, Naina Bhoyar 2
A review of polydopamine sensor in breast cancer diagnosis.
Abstract | Full Text |PDF (882 KB) | Open Access Article
Maryam Abdulrahman Al-Mutairi 1*, Abdulaziz Saeed Alghamdi 1, Mohammed Ibraheem Alshalan 1, Hezam Motlaq H. Alsahly 1, Turki Ahmed k. Almatrafi 1, Fawaz Muslih Roud Alanazi 1, Mohammed Salem S Alqahtani 1, Al Shamari, Abdullah Mohammed K 1, Ali Ishq Mualla Almutairi 1, Mohammed Ali Ibrahim Bakri 1, Saif Mohammed Abdulmohsen Alsahman 1
AI improves triage, diagnostics, and resource allocation in emergency departments, reducing errors and delays while supporting clinicians through enhanced decision-making.
Abstract | Full Text |PDF (461 KB) | Open Access Article
Microbubbles and electromagnetic waves for the treatment of angiogenesis-dependent human ailments
Pegah Moradi
Targeted ultrasound appears practical for the longitudinal molecular profiling of tumor angiogenesis and for the sensitive evaluation of therapy effects in vivo.
Abstract | Full Text |PDF (381 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
The Most Read ranking is based on the number of downloads in the last 60 days from papers published on the Journal of Angiotherapy within the last 12 months. Usage statistics are updated daily.
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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RETRACTED ARTICLE: Predicting Parkinson’s Disease Progression Using Statistical And Neural Mixed Effects Models: Comparative Study On Longitudinal Biomarkers
This study demonstrates interpretable, robust modeling for Parkinson’s telemonitoring, guiding reliable disease progression prediction under small-sample longitudinal data constraints.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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An Integrated AI-Driven Framework for Maternal Resource Intelligence Shortages Across U.S. Hospital
Integrating predictive analytics, reinforcement learning, and causal inference improves maternal outcomes by aligning risk prediction with real-time, equity-aware resource allocation decisions.
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Serum Uric Acid Reduction Following Use of Canssu5®, a Standardized Orthosiphon stamineus Extract, in Adults with Hyperuricemia: A Retrospective Case Study
This study provides preliminary clinical evidence that standardized Orthosiphon stamineus extract may meaningfully reduce serum uric acid in hyperuricemic adults.
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Comprehensive Review of Foundation Toxicity Models Integrating In Vivo, In Vitro, and Chemical Knowledge for Unified Risk Prediction
Bridges experimental and computational toxicology to enable predictive, human-relevant risk assessment frameworks for safer and faster chemical evaluation
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Integrative Molecular and Microbial Mechanisms Linking Liver Fibrosis, Cancer Biology, and Host-Microbe Interactions
This study integrates biomedical and ecological research, revealing shared biological mechanisms that inform therapeutic innovation, sustainable agriculture, and systems-level understanding of complex biological interactions.
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Dietary Bioactive Compounds in Cancer and Cardiovascular Health: A Systematic Review of Methylxanthines, Polyphenols, and Flavonoids
This study demonstrates that dietary bioactive compounds play a significant role in reducing the risk of chronic diseases, improving cardiovascular health, and offering protective effects against certain types of cancer.
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Therapeutic Angiogenesis: From Single-Factor Failures to Precision Vascular Regeneration
Multimodal, precision-guided angiogenic therapies—gene, cell, extracellular vesicle, and biomaterial-based—offer transformative potential for treating ischemic diseases where revascularization remains unfeasible.
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Epigenetic Clocks and Biological Ageing: From Biomarker to Intervention Target
Epigenetic clocks convert DNA methylation into a modifiable biomarker, repositioning ageing as a treatable clinical target.
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Mapping the Invisible Architecture of Disease: Spatial Multi-Omics Technologies, Computational Integration, and the Path Toward Clinical Translation
Spatial multi-omics repositions tissue context as a first-class clinical variable, but equitable, standardized translation remains unfinished business.
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Why Artificial Intelligence Models for Antimicrobial Resistance Still Fail at the Bedside: A Review of Validation, Explainability, and Equity Gaps
Explains why highly accurate AI resistance models fail clinically, and outlines concrete validation, equity, and deployment fixes.
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Single-Cell and Spatial Transcriptomics in Precision Diagnostics: A Roadmap for Clinical Adoption
Spatial transcriptomics reveals disease architecture at cellular resolution, but cost, FFPE limits, and complexity keep it from routine clinical diagnostics.
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From Days to Hours: Artificial Intelligence in Antimicrobial Resistance Diagnostics and Drug Discovery, and Why No Tool Has Yet Reached the Clinic
AI compresses AMR diagnosis and discovery timelines dramatically, yet no tool has reached regulatory clearance — validation and trust, not algorithms, remain the bottleneck.
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The Gut–Brain–Immune Axis in Chronic Disease: Mechanisms and Therapeutic Opportunities — A Narrative Synthesis
This review reframes chronic neurodegenerative and autoimmune disease through a reproducible, microbiome-centered mechanistic and therapeutic lens.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.
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Extracellular Vesicles as Diagnostic and Therapeutic Tools: Closing the Translational Gap
Extracellular vesicles promise cell-free precision diagnostics and therapeutics, but standardization, scalability, and regulatory gaps still block routine clinical adoption.
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Senescent Cell Heterogeneity and Precision Clearance Strategies: From Molecular Mechanism to Clinical Translation
Mapping senescent-cell heterogeneity to precision senotherapies could transform multimorbid, age-related disease treatment safely
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Obesity Pharmacotherapy in the GLP-1 Era: Efficacy, Equity, and the Long-Term Unknowns of Incretin-Based Care
Bariatric-level pharmacotherapy now exists, yet muscle loss, rebound, cost, and pediatric uncertainty still limit its real-world promise.
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Organoid-on-Chip Platforms as Predictive Models of Human Disease: Promise and Pitfalls
Organoid-on-chip systems merge biological fidelity with engineering precision, offering AI-augmented, human-relevant platforms positioned to reshape preclinical drug development.
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Mitochondrial Transfer Between Cells: Physiological Roles and Therapeutic Potential
Intercellular mitochondrial transfer sustains tissue bioenergetics and immunity, offering a transformative, biologically grounded therapeutic strategy for degenerative and ischemic disease.
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Tissue-Resident Memory T Cells in Health and Disease: Emerging Regulators of Immunity
Tissue-resident memory T cells permanently guard peripheral organs, but their dysregulation drives chronic autoimmune disease, making them a precise emerging therapeutic target.
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Multimorbidity in Ageing Populations: Redefining Clinical Guidelines for Combined Disease Management
Frailty-based, mechanism-anchored prescribing frameworks could replace single-disease guidelines that quietly harm complex older patients.
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Long COVID as a Network Disorder: Mechanisms, Biomarkers, and the Path Toward Mechanism-Anchored Clinical Stratification
Reframing Long COVID as a biologically stratifiable network disorder could finally make targeted, effective treatment trials possible.
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Emerging CRISPR-Cas, Antibody, and Nanomedicine Strategies Against Antimicrobial Resistance in Critical Care
AMR is outpacing critical-care antibiotics; precision genomic, antibody, peptide, and nanozyme strategies may restore therapeutic options.
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Integrating Genomics, Transcriptomics, and Organoid-Based Drug Testing for Precision Cancer Care
Integrating transcriptomic, epigenetic, and functional organoid data with genomics may finally close oncology’s persistent gap between diagnosis and matched treatment.
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Digital Biomarkers and Wearable Bioelectronics Across Neurological, Cardiopulmonary, and Mental Health Conditions: Clinical Evidence and Barriers to Adoption
Wearable digital biomarkers show strong clinical validity but require standardized validation, interoperable data systems, and equitable design before routine adoption.
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Modifiable Triggers and Autoimmune Disease Flares: A Mechanistic and Clinical Synthesis of Molecular Mimicry, Barrier Disruption, and Neuroendocrine-Microbial Crosstalk
Environmental exposures converge with genetic risk to trigger autoimmune flares, guiding precision prevention beyond genetics alone.
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Artificial Intelligence in Precision Cardiovascular Medicine: Risk Prediction, Digital Twins, and Explainability
Artificial-intelligence risk models and digital twins could shift cardiology from reactive treatment toward proactive, individualized prevention — if bias, validation, and trust gaps are honestly addressed.
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Moving Beyond the Double-Strand Break Through CRISPR-Based Epigenome Editing for Specificity-Driven Sickle Cell Disease Therapy
Epigenome editing may silence sickle-globin defects without DNA cleavage, offering a safer, durable alternative to nuclease-based gene therapy.
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Non-Coding RNA Networks in Pancreatic Ductal Adenocarcinoma: An Expanding Regulatory Landscape from the ceRNA TRIAD to Exosomal Immune Evasion and Ferroptosis Escape
Non-coding RNA networks orchestrate pancreatic cancer progression, immune evasion, and chemoresistance, revealing druggable nodes for precision therapy.
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Liquid–Liquid Phase Separation as a Unifying Biophysical Driver of Proteinopathy in ALS and Frontotemporal Dementia: Mechanisms, Molecular Grammar, and Therapeutic Vulnerabilities
Mapping how ALS/FTD proteins phase-separate and solidify reveals shared biophysical vulnerabilities that could be therapeutically exploited across the disease spectrum.
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RNA Modifications Reprogram the Epitranscriptome to Drive Hepatocellular Carcinoma Progression
RNA modifications reprogram liver-cancer transcripts to drive growth, immune escape, and drug resistance—offering new biomarkers and druggable targets.
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Protein Language Models for Predicting BRCA1/BRCA2 Variant Pathogenicity: A Computational Bridge Toward Precision Oncology
Protein language models can resolve uncertain BRCA variants rapidly, potentially widening equitable access to PARP-inhibitor therapy worldwide.
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Chromatin Architecture Disruption Drives Transcriptional Dysregulation and Reveals Therapeutic Vulnerabilities in Acute Myeloid Leukaemia
STAG2/cohesin loss and oncofusion proteins collapse 3D chromatin loops in AML, silencing differentiation genes while revealing druggable, reversible epigenetic vulnerabilities.
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Cellular Senescence as a Pathogenic Hub Driving Mechanistic Networks and Reversal Strategies in Idiopathic Pulmonary Fibrosis
Cellular senescence organizes IPF pathogenesis across cell types, positioning senotherapeutics and regenerative cell therapy as biologically grounded strategies for reversing, not merely slowing, fibrosis.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.